Genetic factors in the inflammatory bowel disease

2007 ◽  
pp. 95-103
Author(s):  
I. D. Loranskaya
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Genetic Factors ◽  
Inflammatory Bowel

scholarly journals A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Qingdong Guan
Keyword(s):  
Inflammatory Bowel Disease ◽  
Immune Responses ◽  
Bowel Disease ◽  
Genetic Factors ◽  
Intestinal Inflammation ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Host Genetic ◽  
Inflammatory Bowel ◽  
Host Genetic Factors

Inflammatory bowel disease (IBD) is a chronic and life-threating inflammatory disease of gastroenteric tissue characterized by episodes of intestinal inflammation. The pathogenesis of IBD is complex. Recent studies have greatly improved our knowledge of the pathophysiology of IBD, leading to great advances in the treatment as well as diagnosis of IBD. In this review, we have systemically reviewed the pathogenesis of IBD and highlighted recent advances in host genetic factors, gut microbiota, and environmental factors and, especially, in abnormal innate and adaptive immune responses and their interactions, which may hold the keys to identify novel predictive or prognostic biomarkers and develop new therapies.

scholarly journals Familial Prevalence of Inflammatory Bowel Disease in Northern Alberta

1990 ◽  
Vol 4 (5) ◽  
pp. 184-186
Author(s):  
BR Pinchbeck ◽  
J Kirdeikis ◽  
ABR Thomson
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Relative Risk ◽  
Crohn's Disease ◽  
Bowel Disease ◽  
Genetic Factors ◽  
High Prevalence ◽  
Inflammatory Bowel ◽  
Northern Alberta

Previous studies have reported a high prevalence of inflammatory bowel disease among the relatives, and especially siblings, of patients with Crohn's disease or ulcerative colitis. This high familial prevalence of Crohn's disease and ulcerative colitis suggests that genetic factors could play a role in the development of these disorders. The present study attempted to assess the relative risk for relatives of Crohn's disease and ulcerative colitis patients based on data provided by 1015 questionnaires completed by patients in northern Alberta. A Mx22x2 test among relatives was performed on the diseased versus normal data for each diagnosis to determine if significant differences existed. The prevalence for mothers and sisters was the highest of the relative groups for Crohn's disease ( 6430 of 105and 4670 of 105, respectively). Female relatives tended to have twice the prevalence of their male counterparts. There were differences between mother, daughter and sister prevalence rates for Crohn's disease. These results support the hypothesis that a genetic predisposition in families combined with possible environmental and lifestyle influences determine the relative risk of developing Crohn's disease and ulcerative colitis.

Genetic factors determine extent of bone loss in inflammatory bowel disease

2000 ◽  
Vol 119 (4) ◽  
pp. 909-920 ◽  
Author(s):  
Claudia M.S. Schulte ◽  
Axel U. Dignass ◽  
Harald Goebell ◽  
Hans–Dietrich Röher ◽  
Klaus–Martin Schulte
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bone Loss ◽  
Bowel Disease ◽  
Genetic Factors ◽  
Inflammatory Bowel

scholarly journals Exosomes as a New Delivery Vehicle in Inflammatory Bowel Disease

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1644
Author(s):  
Xiaomei Wang ◽  
Guoliang Zhou ◽  
Wanwan Zhou ◽  
Xin Wang ◽  
Xiao Wang ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Immune Responses ◽  
Intestinal Microbiota ◽  
Bowel Disease ◽  
Genetic Factors ◽  
Research Progress ◽  
Delivery Vehicle ◽  
Non Coding Rna ◽  
Inflammatory Bowel ◽  
Non Coding Rnas

Inflammatory bowel disease (IBD) is a type of chronic relapsing inflammatory disease. The pathogenesis of IBD is still unclear, which may involve environmental factors, genetic factors, intestinal microbiota disorder, and abnormal immune responses. Exosomes (30–150 nm) are found in various body fluids, including blood, saliva, urine, and cerebrospinal fluid. Exosomes mediate intercellular communication and regulate cell biological activity by carrying non-coding RNAs, proteins, and lipids. There is evidence that exosomes are involved in the pathogenesis of IBD. In view of the important roles of exosomes in the pathogenesis of IBD, this work systematically reviews the latest research progress of exosomes in IBD, especially the roles of exosomes as non-coding RNA delivery systems in the pathogenesis of IBD, including a disordered immune response, barrier function, and intestinal microbiota. The review will help to clarify the pathogenesis of IBD and explore new diagnostic markers and therapeutic targets for patients with IBD.

P.67 THROMBOPHILIA IN INFLAMMATORY BOWEL DISEASE: WHAT IS THE IMPACT OF GENETIC FACTORS?

2010 ◽  
Vol 42 ◽  
pp. S126-S127
Author(s):  
M. Cappello ◽  
I. Bravatà ◽  
C. Randazzo ◽  
S. Grimaudo ◽  
R. Pipitone ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Genetic Factors ◽  
Inflammatory Bowel ◽  
The Impact

scholarly journals Pathology of Inflammatory Bowel Disease

2015 ◽  
Vol 5 (9) ◽  
pp. 756-765
Author(s):  
Shiva Raj K.C.
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Gold Standard ◽  
Genetic Factors ◽  
Clinical Laboratory ◽  
Mucosal Immune Response ◽  
Unknown Etiology ◽  
Histopathological Diagnosis ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Inflammatory bowel disease is a group of inflammatory disorders of unknown etiology. Various genetic factors, mucosal immune response, inappropriate activation of immune system driven by the presence of various luminal flora and epithelial defects have been postulated. Crohn disease and Ulcerative colitis are the two most common inflammatory bowel diseases. Since, specific clinical laboratory features are lacking which may help in establishing a diagnosis histopathological diagnosis remains the gold standard. This review highlights the known hypothesis regarding the etiopathogenesis of these two diseases and also describes pertinent histological features.Journal of Pathology of Nepal (2015) Vol. 5, 756-765

scholarly journals An analysis of genetic factors related to risk of inflammatory bowel disease and colon cancer

2014 ◽  
Vol 38 (5) ◽  
pp. 583-590 ◽  
Author(s):  
Bríd M. Ryan ◽  
Roger K. Wolff ◽  
Nicola Valeri ◽  
Mohammed Khan ◽  
Dillon Robinson ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Colon Cancer ◽  
Bowel Disease ◽  
Genetic Factors ◽  
Inflammatory Bowel
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