The Epiphyseal Growth Plate: The Engine That Drives Bone Elongation

2011 ◽  
pp. 1331-1349 ◽  
Author(s):  
Vickram Srinivas ◽  
Irving M. Shapiro
Keyword(s):  
Growth Plate ◽  
Epiphyseal Growth Plate ◽  
Bone Elongation

Effects of Hypophysectomy on the Occurrence and Calcifiability of Matrix Vesicles in the Epiphyseal Growth Plate of Immature Rats

1980 ◽  
Vol 38 ◽  
pp. 578-579
Author(s):  
S. I. Coleman ◽  
W. J. Dougherty
Keyword(s):  
Growth Plate ◽  
Matrix Vesicles ◽  
Epiphyseal Growth Plate ◽  
Hard Tissue ◽  
Hormonal Factors ◽  
Post Surgery ◽  
Mineral Deposition ◽  
Thin Sectioning ◽  
Integral Role ◽  
Cellular Secretion

In the cellular secretion theory of mineral deposition, extracellular matrix vesicles are believed to play an integral role in hard tissue mineralization (1). Membrane limited matrix vesicles arise from the plasma membrane of epiphyseal chondrocytes and tooth odontoblasts by a budding process (2, 3). Nutritional and hormonal factors have been postulated to play essential roles in mineral deposition and apparently have a direct effect on matrix vesicles of calcifying cartilage as concluded by Anderson and Sajdera (4). Immature (75-85 gm) Long-Evans hooded rats were hypophysectomized by the parapharyngeal approach and maintained fourteen (14) days post-surgery. At this time, the animals were anesthetized and perfusion fixed in cacodylate buffered 2.5% glutaraldehyde. The proximal tibias were quickly dissected out and split sagittally. One half was used for light microscopy (LM) and the other for electron microscopy (EM). The halves used for EM were cut into blocks approximately 1×3 mm. The tissue blocks were prepared for ultra-thin sectioning and transmission EM. The tissue was oriented so as to section through the epiphyseal growth plate from the zone of proliferating cartilage on down through the hypertrophic zone and into the initial trabecular bone. Sections were studied stained (double heavy metal) and unstained.

Effects of cyclophosphamide on the femural epiphyseal growth plate in young Sprague-Dawley rats

2002 ◽  
Vol 60 (4) ◽  
pp. 208-212 ◽  
Author(s):  
Oded Zilberman ◽  
Margareta Näsman ◽  
Carl-Magnus Forsberg ◽  
Sven Lindskog
Keyword(s):  
Growth Plate ◽  
Sprague Dawley ◽  
Epiphyseal Growth Plate ◽  
Sprague Dawley Rats

Ultrastructure of the rat epiphyseal growth plate following chronic ethanol ingestion

1981 ◽  
Vol 33 (1) ◽  
pp. 381-384 ◽  
Author(s):  
Michael D. Fallon ◽  
Daniel T. Baran ◽  
R. Bruce Craig ◽  
Steven L. Teitelbaum
Keyword(s):  
Growth Plate ◽  
Chronic Ethanol ◽  
Ethanol Ingestion ◽  
Epiphyseal Growth Plate

scholarly journals Effects of bisphosphonates on different zones of the epiphyseal growth plate of rats

2021 ◽  
Vol 10 (14) ◽  
pp. e518101422159
Author(s):  
Deise Ponzoni ◽  
Elissa Kerli Fernandes ◽  
Mateus Muller da Silva ◽  
Izabel Cristina Custódio de Souza ◽  
John Kim Neubert ◽  
...  
Keyword(s):  
Growth Plate ◽  
Histological Analysis ◽  
Skeletal Development ◽  
Fold Increase ◽  
Control Group ◽  
Epiphyseal Growth Plate ◽  
Alendronate Sodium ◽  
Proliferative Zone ◽  
Clinical Disorders ◽  
Plate Cell

Bisphosphonates (BIS) are indicated for several clinical disorders (e.g., osteoporosis). However, BIS has been associated with osteonecrosis and alterations in osteoclastogenesis and skeletal development. This study aimed to evaluate the effects of BIS (zoledronic acid - ZA and alendronate sodium - AS) on zones of the growth plate of rat femur. Animals (Wistar rats, n = 19) were divided into groups: 1) AS Group: animals received alendronate sodium orally (3 mg/kg per day); 2) ZA Group: ZA was administered intraperitoneally (0.2 mg/kg per week); and 3) Control Group (CG): a vehicle was administered. Animals were euthanized 21 days after the treatment, and femurs were collected for histological analysis. The images of all zones (resting, proliferative, hypertrophic, and calcified) were processed by the Qcapture® software providing a 40 and 400-fold increase.  ZA decreased epiphyseal growth plate cell zones (ZA Group vs. CG) in most cases. Likewise, AS diminished the proliferative zone (AS Group vs. CG). Furthermore, ZA increased the calcified zone (ZA Group vs. CG). Previous works demonstrated that BIS decrease the epiphyseal disc. This reduction is probably due to the shortening of the cellular zones that undergoes calcification/ossification. The present results suggest that BIS should be carefully indicated because these drugs might accelerate epiphyseal closure.

Double-barrel vascularized dual fibula transfer with epiphyseal growth plate for hip reconstruction: A case report

Microsurgery ◽  
2018 ◽  
Vol 38 (5) ◽  
pp. 572-575
Author(s):  
Fabio Santanelli di Pompeo ◽  
Gennaro Selvaggi ◽  
Benedetto Longo ◽  
Rosaria Laporta ◽  
Vittoria Amorosi ◽  
...  
Keyword(s):  
Case Report ◽  
Growth Plate ◽  
Epiphyseal Growth Plate ◽  
Hip Reconstruction

scholarly journals Osseous malformation in calves and its relationship with ingestion of apple pomace in pregnant cows

2019 ◽  
Vol 39 (5) ◽  
pp. 304-307
Author(s):  
Nathalia S. Wicpolt ◽  
Aldo Gava
Keyword(s):  
Growth Plate ◽  
Rio Grande ◽  
Growth Zone ◽  
Apple Pomace ◽  
Rio Grande Do Sul ◽  
Epiphyseal Growth Plate ◽  
Bone Deformity ◽  
Cattle Feeding ◽  
Thin Bone ◽  
Bone Trabeculae

ABSTRACT: Three outbreaks of osseous malformation in claves born of cows fed apple pomace throughout pregnancy are described. This study was carried out from historical surveys on properties where apple pomace was used in cattle feeding. The outbreaks occurred in the municipalities of Lages, Santa Catarina state, from 2007 to 2012, and Ipê, Rio Grande do Sul state, from 2011 to 2012. These calves presented bone deformity characterized mainly by arthrogryposis and chondrodysplasia of the anterior limbs. At necropsy, the observed changes were restricted to bending and thickening of the anterior limbs and skull. Microscopically, a disorganized, irregular, misaligned hypertrophic zone was observed in the humeral-radio-ulnar joints, in addition to absence of growth zone, thin bone trabeculae, and closed epiphyseal growth plate.

Shear Stress in Epiphyseal Growth Plate is a Risk Factor for Slipped Capital Femoral Epiphysis

2008 ◽  
Vol 28 (4) ◽  
pp. 444-451 ◽  
Author(s):  
Oskar Zupanc ◽  
Miran Križančič ◽  
Matej Daniel ◽  
Blaž Mavčič ◽  
Vane Antolič ◽  
...  
Keyword(s):  
Shear Stress ◽  
Risk Factor ◽  
Growth Plate ◽  
Slipped Capital Femoral Epiphysis ◽  
Epiphyseal Growth Plate
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