Memory T-Cell Responses and Survival in Human Cancer: Remember to Stay Alive

2010 ◽  
pp. 166-177 ◽  
Author(s):  
Matthieu Camus ◽  
Jérôme Galon
Keyword(s):  
T Cell ◽  
Human Cancer ◽  
T Cell Responses ◽  
Memory T Cell ◽  
Cell Responses

scholarly journals Detection of IFNγ-Secreting CD4+ and CD8+ Memory T Cells in COVID-19 Convalescents after Stimulation of Peripheral Blood Mononuclear Cells with Live SARS-CoV-2

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1490
Author(s):  
Victoria Matyushenko ◽  
Irina Isakova-Sivak ◽  
Igor Kudryavtsev ◽  
Arina Goshina ◽  
Anna Chistyakova ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Memory T Cells ◽  
Natural Infection ◽  
Intracellular Cytokine Staining ◽  
T Cell Responses ◽  
Effector Memory ◽  
Memory T Cell ◽  
Cell Responses ◽  
Stimulation Of

Background: New coronavirus SARS-CoV-2, a causative agent of the COVID-19 pandemic, has been circulating among humans since November 2019. Multiple studies have assessed the qualitative and quantitative characteristics of virus-specific immunity in COVID-19 convalescents, however, some aspects of the development of memory T-cell responses after natural SARS-CoV-2 infection remain uncovered. Methods: In most of published studies T-cell immunity to the new coronavirus is assessed using peptides corresponding to SARS-CoV-1 or SARS-CoV-2 T-cell epitopes, or with peptide pools covering various parts of the viral proteins. Here, we determined the level of CD4+ and CD8+ memory T-cell responses in COVID-19 convalescents by stimulating PBMCs collected 1 to 6 months after recovery with sucrose gradient-purified live SARS-CoV-2. IFNγ production by the central and effector memory helper and cytotoxic T cells was assessed by intracellular cytokine staining assay and flow cytometry. Results: Stimulation of PBMCs with live SARS-CoV-2 revealed IFNγ-producing T-helper effector memory cells with CD4+CD45RA−CCR7− phenotype, which persisted in circulation for up to 6 month after COVID-19. In contrast, SARS-CoV-2-specific IFNγ-secreting cytotoxic effector memory T cells were found at significant levels only shortly after the disease, but rapidly decreased over time. Conclusion: The stimulation of immune cells with live SARS-CoV-2 revealed a rapid decline in the pool of effector memory CD8+, but not CD4+, T cells after recovery from COVID-19. These data provide additional information on the development and persistence of cellular immune responses after natural infection, and can inform further development of T cell-based SARS-CoV-2 vaccines.

scholarly journals Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma

2021 ◽  
Author(s):  
Zhuting Hu ◽  
Donna E. Leet ◽  
Rosa L. Allesøe ◽  
Giacomo Oliveira ◽  
Shuqiang Li ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Epitope Spreading ◽  
Memory T Cell ◽  
Cell Responses ◽  
Persistent Memory

scholarly journals IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Lyssia Belarif ◽  
Caroline Mary ◽  
Lola Jacquemont ◽  
Hoa Le Mai ◽  
Richard Danger ◽  
...  
Keyword(s):  
T Cell ◽  
Chronic Inflammation ◽  
T Cell Responses ◽  
Receptor Blockade ◽  
Memory T Cell ◽  
Cell Responses ◽  
Specific Memory

scholarly journals Norovirus-Specific Memory T Cell Responses in Adult Human Donors

2016 ◽  
Vol 7 ◽  
Author(s):  
Maria Malm ◽  
Kirsi Tamminen ◽  
Timo Vesikari ◽  
Vesna Blazevic
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Memory T Cell ◽  
Cell Responses ◽  
Adult Human ◽  
Specific Memory

scholarly journals Ex Vivo Cytokine and Memory T Cell Responses to the 42-kDa Fragment ofPlasmodium falciparumMerozoite Surface Protein-1 in Vaccinated Volunteers

2008 ◽  
Vol 180 (3) ◽  
pp. 1451-1461 ◽  
Author(s):  
Maria Cecilia Huaman ◽  
Laura B. Martin ◽  
Elissa Malkin ◽  
David L. Narum ◽  
Louis H. Miller ◽  
...  
Keyword(s):  
T Cell ◽  
Ex Vivo ◽  
Surface Protein ◽  
T Cell Responses ◽  
Memory T Cell ◽  
Cell Responses

scholarly journals Antibody Avidity in Humoral Immune Responses in Bangladeshi Children and Adults following Administration of an Oral Killed Cholera Vaccine

2013 ◽  
Vol 20 (10) ◽  
pp. 1541-1548 ◽  
Author(s):  
Mohammad Murshid Alam ◽  
Daniel T. Leung ◽  
Marjahan Akhtar ◽  
Mohammad Nazim ◽  
Sarmin Akter ◽  
...  
Keyword(s):  
T Cell ◽  
B Cell ◽  
T Cell Responses ◽  
Memory B Cell ◽  
Antibody Avidity ◽  
Memory T Cell ◽  
Cell Responses ◽  
Specific Memory ◽  
Iga Antibodies ◽  
Specific Igg

ABSTRACTAntibody avidity for antigens following disease or vaccination increases with affinity maturation and somatic hypermutation. In this study, we followed children and adults in Bangladesh for 1 year following oral cholera vaccination and measured the avidity of antibodies to the T cell-dependent antigen cholera toxin B subunit (CTB) and the T cell-independent antigen lipopolysaccharide (LPS) in comparison with responses in other immunological measurements. Children produced CTB-specific IgG and IgA antibodies of high avidity following vaccination, which persisted for several months; the magnitudes of responses were comparable to those seen in adult vaccinees. The avidity of LPS-specific IgG and IgA antibodies in vaccinees increased significantly shortly after the second dose of vaccine but waned rapidly to baseline levels thereafter. CTB-specific memory B cells were present for only a short time following vaccination, and we did not find significant memory B cell responses to LPS in any age group. For older children, there was a significant correlation between CTB-specific memory T cell responses after the second dose of vaccine and CTB-specific IgG antibody avidity indices over the subsequent year. These findings suggest that vaccination induces a longer-lasting increase in the avidity of antibodies to a T cell-dependent antigen than is measured by a memory B cell response to that antigen and that early memory T cell responses correlate well with the subsequent development of higher-avidity antibodies.

Belatacept Can Inhibit Allo-Specific T Cell Responses in a Donor-Dependent Manner But Preserves Virus-Specific Memory T Cell-Responses.

2014 ◽  
Vol 98 ◽  
pp. 36
Author(s):  
C. Falk ◽  
K. Daemen ◽  
M. Stevanovic-Meyer ◽  
F. Lehner ◽  
H. Haller ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Dependent Manner ◽  
Memory T Cell ◽  
Cell Responses ◽  
Specific Memory

scholarly journals Luteolin-mediated Kv1.3 K+ channel inhibition augments BCG vaccine efficacy against tuberculosis by promoting central memory T cell responses in mice

2020 ◽  
Vol 16 (9) ◽  
pp. e1008887
Author(s):  
Dhiraj Kumar Singh ◽  
Ved Prakash Dwivedi ◽  
Shashi Prakash Singh ◽  
Anjna Kumari ◽  
Saurabh Kumar Sharma ◽  
...  
Keyword(s):  
T Cell ◽  
Vaccine Efficacy ◽  
T Cell Responses ◽  
Central Memory ◽  
Bcg Vaccine ◽  
K Channel ◽  
Memory T Cell ◽  
Cell Responses ◽  
Channel Inhibition
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