Studies on two-phase gas-liquid co-current flow with non-Newtonian liquid system has attracted the attention of researchers over the years due to its wide-spread applications and importance in various different processes in chemical and biochemical industries, such as the process of two-phase in oil and gas wells, transportation systems of crude and refined products, and food processing in biochemical engineering and bio-reactors. This article examines the sole objective of experimental studies on gas holdup in Newtonian and non-Newtonian liquid slug flow within a range of gas and liquid flowrate of 0.5×10-4 to 1.92×10-4 m3/s and 1.6×10-4 to 6.7×10-4 m3/s, respectively. The present data was analyzed with different models. To predict gas holdup, correlations have been developed for individual system with Newtonian and non-Newtonian liquid. A general correlation was also developed to predict the gas holdup combing both the Newtonian and non-Newtonian liquid systems. The study of the gas holdup characteristics in gas-Newtonian and non-Newtonian liquid systems may give insight into a further understanding and modeling of this slug flow characteristics in industrial applications.