Treatment of Subacute and Chronic Thrombotic Occlusions of the Lower Extremity Peripheral Arteries: The Role of Excimer Laser

2015 ◽  
pp. 157-166
Author(s):  
Nicolas W. Shammas
Keyword(s):  
Lower Extremity ◽  
Excimer Laser ◽  
Peripheral Arteries

Treatment of subacute and chronic thrombotic occlusions of lower extremity peripheral arteries with the excimer laser: a feasibility study

2012 ◽  
Vol 13 (4) ◽  
pp. 211-214 ◽  
Author(s):  
Nicolas W. Shammas ◽  
Neil J. Weissman ◽  
Denise Coiner ◽  
Gail A. Shammas ◽  
Eric Dippel ◽  
...  
Keyword(s):  
Lower Extremity ◽  
Excimer Laser ◽  
Feasibility Study ◽  
Peripheral Arteries

Coronary Intervention with the Excimer Laser: Review of the Technology and Outcome Data

2016 ◽  
Vol 11 (1) ◽  
pp. 27
Author(s):  
John Rawlins ◽  
◽  
◽  
◽  
◽  
...  
Keyword(s):  
Excimer Laser ◽  
Coronary Intervention ◽  
Outcome Data ◽  
Boston Scientific ◽  
Technical Aspects ◽  
Safety And Efficacy ◽  
Percutaneous Coronary ◽  
Short Period ◽  
Complex Lesions

Excimer laser coronary atherectomy (ELCA) is a long-established adjunctive therapy that can be applied during percutaneous coronary intervention (PCI). Technical aspects have evolved and there is an established safety and efficacy record across a number of clinical indications in contemporary interventional practice where complex lesions are routinely encountered. The role of ELCA during PCI for thrombus, non-crossable or non-expandable lesions, chronic occlusions and stent under-expansion are discussed in this review. The key advantage of ELCA over alternative atherectomy interventions is delivery on a standard 0.014-inch guidewire. Additionally, the technique can be mastered by any operator after a short period of training. The major limitation is presence of heavy calcification although when rotational atherectomy (RA) is required but cannot be applied due to inability to deliver the dedicated RotaWire™ (Boston Scientific), ELCA can create an upstream channel to permit RotaWire passage and complete the case with RA – the RASER technique.

scholarly journals Molecular Mechanisms Associated with ROS-Dependent Angiogenesis in Lower Extremity Artery Disease

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 735
Author(s):  
Greg Hutchings ◽  
Łukasz Kruszyna ◽  
Mariusz J. Nawrocki ◽  
Ewa Strauss ◽  
Rut Bryl ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Blood Vessel ◽  
Lower Extremity ◽  
Molecular Mechanisms ◽  
Lower Extremities ◽  
Tissue Response ◽  
Peripheral Arteries ◽  
Artery Disease ◽  
Lower Extremity Artery Disease

Currently, atherosclerosis, which affects the vascular bed of all vital organs and tissues, is considered as a leading cause of death. Most commonly, atherosclerosis involves coronary and peripheral arteries, which results in acute (e.g., myocardial infarction, lower extremities ischemia) or chronic (persistent ischemia leading to severe heart failure) consequences. All of them have a marked unfavorable impact on the quality of life and are associated with increased mortality and morbidity in human populations. Lower extremity artery disease (LEAD, also defined as peripheral artery disease, PAD) refers to atherosclerotic occlusive disease of the lower extremities, where partial or complete obstruction of peripheral arteries is observed. Decreased perfusion can result in ischemic pain, non-healing wounds, and ischemic ulcers, and significantly reduce the quality of life. However, the progressive atherosclerotic changes cause stimulation of tissue response processes, like vessel wall remodeling and neovascularization. These mechanisms of adapting the vascular network to pathological conditions seem to play a key role in reducing the impact of the changes limiting the flow of blood. Neovascularization as a response to ischemia induces sprouting and expansion of the endothelium to repair and grow the vessels of the circulatory system. Neovascularization consists of three different biological processes: vasculogenesis, angiogenesis, and arteriogenesis. Both molecular and environmental factors that may affect the process of development and growth of blood vessels were analyzed. Particular attention was paid to the changes taking place during LEAD. It is important to consider the molecular mechanisms underpinning vessel growth. These mechanisms will also be examined in the context of diseases commonly affecting blood vessel function, or those treatable in part by manipulation of angiogenesis. Furthermore, it may be possible to induce the process of blood vessel development and growth to treat peripheral vascular disease and wound healing. Reactive oxygen species (ROS) play an important role in regulation of essential cellular signaling pathways such as cell differentiation, proliferation, migration and apoptosis. With regard to the repair processes taking place during diseases such as LEAD, prospective therapeutic methods have been described that could significantly improve the treatment of vessel diseases in the future. Summarizing, regenerative medicine holds the potential to transform the therapeutic methods in heart and vessel diseases treatment.

Grain Enlargement of Polycrystalline Silicon by Multipulse Excimer Laser Annealing: Role of Hydrogen

2006 ◽  
Vol 45 (4A) ◽  
pp. 2726-2730 ◽  
Author(s):  
Naoya Kawamoto ◽  
Atsushi Masuda ◽  
Naoto Matsuo ◽  
Yasuhiro Seri ◽  
Toshimasa Nishimori ◽  
...  
Keyword(s):  
Excimer Laser ◽  
Polycrystalline Silicon ◽  
Laser Annealing ◽  
Excimer Laser Annealing

Excimer Laser Tissue Ablation : The Potential Role of Laser Induced Shock Waves and Problems Associated with Contact Dependent Multifiber Laser Catheter

1992 ◽  
Vol 22 (5) ◽  
pp. 811
Author(s):  
Seung-Jea Tahk ◽  
Herbert J. Geschwind ◽  
Takanobu Tomaru ◽  
Georges Boussignac
Keyword(s):  
Shock Waves ◽  
Excimer Laser ◽  
Potential Role ◽  
Tissue Ablation

Visuomotor tracking with the lower extremity: the role of visual feedback in task performance

2008 ◽  
Vol 1 (3) ◽  
pp. 311
Author(s):  
S. Hotz-Boendermaker ◽  
J. Petersen ◽  
M. Laubacher ◽  
M.-C. Hepp-Reymond ◽  
M. Schubert
Keyword(s):  
Lower Extremity ◽  
Task Performance ◽  
Visual Feedback ◽  
Visuomotor Tracking

OP23 Role of hydrogen sulfide in leptin-induced endothelium-dependent vasorelaxation of peripheral arteries in lean and obese rats

Nitric Oxide ◽  
2013 ◽  
Vol 31 ◽  
pp. S29
Author(s):  
Anna Jamroz-Wiśniewska ◽  
Arieh Gertler ◽  
Gili Solomon ◽  
Matthew Whiteman ◽  
Jerzy Bełtowski
Keyword(s):  
Hydrogen Sulfide ◽  
Peripheral Arteries ◽  
Obese Rats
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