Esophageal Transit Time Evaluated by Means of the Biomagnetic and Scintigraphic Methods

Retention of tablets or capsules in the feline esophagus can be associated with esophagitis and esophageal stricture formation. The objective of this study was to evaluate the esophageal passage of tablets and capsules when administered with either a one-step pill gun with flavored liquid (FlavoRx pill glide) or a pill delivery treat (Pill Pockets). Four different medication administrations were evaluated on different days in eight normal cats: tablets with FlavoRx pill glide (T-FG), tablets with pill delivery treats (T-PP), capsules with FlavoRx pill glide (C-FG) and capsules with pill delivery treats (C-PP). The estimated average transit time was 36 s for T-FG, 60 s for T-PP, 16 s for C-FG, and 24 s for C-PP. The results of this study suggest that either pill delivery method is acceptable for successful passage of tablets or capsules into the stomach of cats using a single replicate.

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Esophageal transit time in patients with chagasic megaesophagus

Medicine ◽

10.1097/md.0000000000010084 ◽

2018 ◽

Vol 97 (10) ◽

pp. e0084

Author(s):

Paula Martins ◽

Cid Sergio Ferreira ◽

José Renan Cunha-Melo

Keyword(s):

Transit Time ◽

Esophageal Transit ◽

Chagasic Megaesophagus

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Factors Influencing the Transit of a Gelatin Capsule in the Esophagus

Drug Intelligence & Clinical Pharmacy ◽

10.1177/106002808702100311 ◽

1987 ◽

Vol 21 (3) ◽

pp. 282-285 ◽

Cited By ~ 19

Author(s):

Robert T. Bailey ◽

Luigi Bonavina ◽

Lawrence McChesney ◽

Kelly J. Spires ◽

Mark I. Muilenburg ◽

...

Keyword(s):

Transit Time ◽

Mean Amplitude ◽

The Elderly ◽

Esophageal Injury ◽

Elderly Subjects ◽

Gelatin Capsule ◽

Drug Induced ◽

Esophageal Transit ◽

Lower Amplitude ◽

Asymptomatic Volunteers

The tendency of a gelatin capsule to lodge in the esophagus, dissolve, and release its contents, as a potential etiology of drug-induced esophageal injury, was studied in 18 asymptomatic volunteers. Their ages ranged from 21 to 81 years, with nine subjects over 70 years old. Esophageal transit time of liquids was measured in all subjects after which the esophageal transit time of a #00 gelatin capsule containing technetium (99mTc) sulfur colloid was measured with a 120 ml and a 15 ml water bolus. The capsule lodged in three subjects (17 percent) with the 120 ml bolus and in 11 subjects (61 percent) with the 15 ml bolus. Esophageal manometry demonstrated a lower mean amplitude of esophageal contractions in subjects in whom the capsule lodged with the 120 ml bolus and in the elderly subjects. We conclude that the esophageal transit time of a gelatin capsule is related to the volume of fluid chaser. Our findings that a lower amplitude of esophageal contractions was associated with elderly patients and those in whom the capsule lodged with the large fluid bolus are worthy of further investigation.

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Radionuclide esophageal transit time in patients of suspected esophageal motility disorders

Indian Journal of Gastroenterology ◽

10.1007/s12664-009-0024-1 ◽

2009 ◽

Vol 28 (2) ◽

pp. 74-75 ◽

Cited By ~ 2

Author(s):

S. H. Khan ◽

T. A. Rather ◽

B. ul Rehman ◽

G. M. Gulzar ◽

T. A. Mir ◽

...

Keyword(s):

Transit Time ◽

Esophageal Motility ◽

Esophageal Motility Disorders ◽

Motility Disorders ◽

Esophageal Transit

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374 VIDEO ESOPHAGOGRAM CORRELATES OF DYSPHAGIA IN PATIENTS WITH NORMAL LOWER ESOPHAGEAL SPHINCTER

Diseases of the Esophagus ◽

10.1093/dote/doaa087.91 ◽

2020 ◽

Vol 33 (Supplement_1) ◽

Author(s):

D Razia ◽

L Giulini ◽

R Bremner ◽

S Mittal

Keyword(s):

Prone Position ◽

Transit Time ◽

Esophageal Wall ◽

Bolus Transit ◽

Esophageal Transit ◽

Dysphagia Score ◽

Esophageal Spasm ◽

Number Of Patients ◽

The Difference ◽

Barium Esophagogram

Abstract Dysphagia is a common foregut symptom. However, there is poor association between non-obstructive dysphagia and esophageal body peristaltic parameters in patients with normal lower esophageal sphincters (LES). The objective of this retrospective study was to study bolus transit patterns noted on barium esophagogram in patients experiencing dysphagia. Methods After IRB approval, we queried our esophageal database for patients with normal manometric LES. Jackhammer esophagus, esophageal spasm, previous foregut surgery, and unavailable foregut symptom questionnaires were exclusion criteria. Patients were grouped based on reported dysphagia: 0 = None; 1 = Mild; 2 = Moderate; 3 = Severe/very severe. All barium esophagograms were re-evaluated. Bolus esophageal transit time was studied with patients in both upright and prone positions, using live time stamps at bolus entry/exit. “Barium residue” was defined as persistent contrast on the esophageal wall after bolus exit. “Retrograde escape” referred to barium escaping proximally from the bolus into previously cleared esophagus. ANOVA and χ2 were used. Results In all, 150 patients met inclusion criteria. 76 (50.1%) were women. Mean age and body mass index were 58.4 ± 14.7 years and 22.9 ± 10.4 kg/m2, respectively. The number of patients in each dysphagia group (0, 1, 2, and 3) were 82(54.7%), 29(19.3%), 25(16.7%) and 14(9.3%), respectively. The difference in mean bolus transit time among dysphagia groups was statistically significant in prone-position swallows (39.3 ± 36.7, 75 ± 74.8, 98.8 ± 85 and 69.6 ± 43.7 seconds; p < 0.001) but not in upright-position swallows (14.6 ± 22, 12.4 ± 8.1, 14.3 ± 8.8 and 12.6 ± 8.2 seconds; p = 0.929; Fig. 1). The prevalence of residual contrast and retrograde escape in prone swallows were comparable among patients reporting dysphagia (p = 0.444, p = 0.173). Conclusion Bolus transit time in prone-position barium swallows is simple to assess, and correlates with dysphagia reported by patients with normal lower esophageal sphincters. However, further studies with comprehensive dysphagia score are needed.

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Measurement of the Esophageal Transit Time Using a Magnetic Marker

10.1063/1.1811841 ◽

2004 ◽

Author(s):

T. Córdova-Fraga

Keyword(s):

Transit Time ◽

Esophageal Transit ◽

Magnetic Marker

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Postoperative Dysphagia versus Neurogenic Dysphagia: Scintigraphic Assessment

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348940311200106 ◽

2003 ◽

Vol 112 (1) ◽

pp. 20-28 ◽

Cited By ~ 16

Author(s):

Venanzio Valenza ◽

AnaMaria Samanes Gajate ◽

Jacopo Galli ◽

Lucia D'Alatri ◽

Stefano Di Girolamo ◽

...

Keyword(s):

Oral Cavity ◽

Transit Time ◽

Retention Index ◽

Normal Subjects ◽

Mean Value ◽

Esophageal Transit ◽

Maximum Value ◽

Group 3 ◽

Group 2 ◽

Group 1

In order to differentiate the features of dysphagia that occur after supraglottic horizontal laryngectomy from those that occur during neurologic diseases, we divided 38 subjects into 3 groups and submitted them to oropharyngoesophageal scintigraphy. Group 1 (control group) included 15 healthy volunteeers; group 2 comprised 8 patients who had residual dysphagia at least 1 year after supraglottic laryngectomy; and group 3 included 15 patients with various neurologic and neuromuscular disorders. In group 1, the mean values (±2 SD) of selected semiquantitative parameters were consistent with those reported in the literature for normal subjects. In group 2, oral, pharyngeal, and esophageal transit times were not significantly altered, and moderate tracheobronchial postdeglutitive aspiration was present (maximum value, 6.7%; mean value, 2.04%). The pharyngeal retention index was significantly increased (p = .0003) as compared to normal subjects in all cases (maximum value, 40%; mean value, 23%) and was associated in all cases with slight but consistent postdeglutitive aspiration. In group 3, the oral and esophageal phases were significantly prolonged and the retention indices were significantly increased. Statistical analysis documented a significant increase in oral transit time (p = .003), esophageal transit time (p = .01), oral retention index (p = .006), pharyngeal retention index (p = .0007), and esophageal retention index (p = .009) as compared to normal subjects. The swallowing pattern was also altered by 1) an early loss of the bolus from the oral cavity; 2) bolus fragmentation due to double or triple deglutition, reduced lingual propulsion, or the return of a small part of the bolus into the oral cavity during deglutition; and/or 3) double pharyngeal peaks in the activity-time curves. Tracheobronchial aspiration (maximum value, 90%; mean value, 9.70%) was present in some cases, mainly in patients affected by post-stroke dysphagia. On the basis of the obtained results and considering the low doses of radiation delivered to the patient (0.043 Gy), the limited invasiveness, and the excellent patient tolerance, scintigraphy appears to be clinically valid in the functional study of swallowing and in identifying different deglutition disorders.

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