A comparative study evaluating the esophageal transit time of eight healthy cats when pilled with the FlavoRx pill glide versus pill delivery treats

2010 ◽  
Vol 12 (4) ◽  
pp. 286-290 ◽  
Author(s):  
Alexander D. Bennett ◽  
Catriona M. MacPhail ◽  
Debra S. Gibbons ◽  
Michael R. Lappin
Keyword(s):  
Comparative Study ◽  
Transit Time ◽  
Esophageal Stricture ◽  
Stricture Formation ◽  
Delivery Method ◽  
Esophageal Transit ◽  
One Step

Retention of tablets or capsules in the feline esophagus can be associated with esophagitis and esophageal stricture formation. The objective of this study was to evaluate the esophageal passage of tablets and capsules when administered with either a one-step pill gun with flavored liquid (FlavoRx pill glide) or a pill delivery treat (Pill Pockets). Four different medication administrations were evaluated on different days in eight normal cats: tablets with FlavoRx pill glide (T-FG), tablets with pill delivery treats (T-PP), capsules with FlavoRx pill glide (C-FG) and capsules with pill delivery treats (C-PP). The estimated average transit time was 36 s for T-FG, 60 s for T-PP, 16 s for C-FG, and 24 s for C-PP. The results of this study suggest that either pill delivery method is acceptable for successful passage of tablets or capsules into the stomach of cats using a single replicate.

Esophageal Transit Time Evaluated by Means of the Biomagnetic and Scintigraphic Methods

Biomag 96 ◽  
2000 ◽  
pp. 612-615
Author(s):  
N. A. Daghastanli ◽  
F. J. H. N. Braga ◽  
R. B. Oliveira ◽  
O. Baffa
Keyword(s):  
Transit Time ◽  
Esophageal Transit

scholarly journals A novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosis

2014 ◽  
Vol 52 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Murat Dereli ◽  
Bartlomiej E. Krazinski ◽  
Suleyman Ayvaz ◽  
Burhan Aksu ◽  
Mehmet Kanter ◽  
...  
Keyword(s):  
Esophageal Stricture ◽  
Stricture Formation ◽  
Novel Approach

scholarly journals Prevention Effect of TGF-β Type I Receptor Kinase Inhibitor in Esophageal Stricture Formation after Corrosive Burn

2021 ◽  
Author(s):  
Min Tae Kim ◽  
Kun Yung Kim
Keyword(s):  
Treatment Group ◽  
Esophageal Stricture ◽  
Kinase Inhibitor ◽  
Good Alternative ◽  
Esophageal Stenosis ◽  
Area Ratio ◽  
Control Group ◽  
Stricture Formation ◽  
Type I ◽  
Group A

Corrosive burns lead to progressive esophageal stricture and dysphagia. There are many trials to prevent Esophageal stricture formation after corrosive burn. This study aimed to access the effects of EW-7197 on prevention for esophageal stricture formation after corrosive esophageal burn. animal study were classified divided into three groups: a healthy group, a control group (corrosive burn without EW-7197), and a treatment group (corrosive burn with EW-7197). Corrosive esophageal burns were produced using 30% NaOH on the lower esophagus. For 3 weeks, the control group received vehicle and the treatment group received 20 mg/kg/day EW-7197. Treatment efficacy was assessed by measuring the stenosis ratio by esophagogram with contrast media on day 21. histologic staining was performed to evaluate the fibrosis area ratio, and western blotting was performed to evaluate fibrotic markers. Among 20 rats that underwent surgery, 14 survived. Three in the treatment group died because of esophageal perforation, and three in the control group died due to their debilitating status. The esophageal stenosis ratio was significantly lower in the treatment group than in the control group (12.1 ± 9.5% and 42.2 ± 8.3%, respectively; p = 0.001). The histologic fibrosis area ratio was also significantly lower in the treatment group (12.5 ± 3.0% and 21.6 ± 2.1%, respectively; p = 0.001). The treatment group showed lower expressions of profibrogenic proteins such as TGF-β1, pSmad3, and α-SMA. EW-7197 may be a good alternative for the prevention esophageal stricture formation after corrosive burn.

Comparative study of conventional vs. one-step-interconnected (OSI) monolithic CdTe modules

2015 ◽  
Vol 19 (7) ◽  
pp. 488-493
Author(s):  
G. Kartopu ◽  
M. Crozier ◽  
A. Brunton ◽  
V. Barrioz ◽  
S. Hodgson ◽  
...  
Keyword(s):  
Comparative Study ◽  
One Step

scholarly journals Esophageal transit time in patients with chagasic megaesophagus

Medicine ◽  
2018 ◽  
Vol 97 (10) ◽  
pp. e0084
Author(s):  
Paula Martins ◽  
Cid Sergio Ferreira ◽  
José Renan Cunha-Melo
Keyword(s):  
Transit Time ◽  
Esophageal Transit ◽  
Chagasic Megaesophagus

Mucosal loss as a critical factor in esophageal stricture formation after mucosal resection: a pilot experiment in a porcine model

2019 ◽  
Vol 34 (2) ◽  
pp. 551-556
Author(s):  
Bing-Rong Liu ◽  
Dan Liu ◽  
Wenyi Yang ◽  
Saif Ullah ◽  
Zhen Cao ◽  
...  
Keyword(s):  
Esophageal Stricture ◽  
Porcine Model ◽  
Critical Factor ◽  
Stricture Formation ◽  
Pilot Experiment ◽  
Mucosal Resection

scholarly journals 4-Nitrophenyl activated esters are superior synthons for indirect radiofluorination of biomolecules

2020 ◽  
Vol 11 (8) ◽  
pp. 919-922
Author(s):  
Mohammad B. Haskali ◽  
Ashleigh L. Farnsworth ◽  
Peter D. Roselt ◽  
Craig A. Hutton
Keyword(s):  
Comparative Study ◽  
Small Molecules ◽  
Activated Esters ◽  
One Step ◽  
Prosthetic Groups

A comparative study of PNP- and TFP-activated esters of radiolabelled prosthetic groups demonstrates the superiority of PNP esters in terms of stability and yields for use in one-step radiolabelling of small molecules and peptides.

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