Dysregulation of Cytokine Gene Expression as a Cause of T Cell Transformation and In Vivo Tumorigenicity

1996 ◽  
pp. 565-570
Author(s):  
Mona R. Hassuneh ◽  
Prakash S. Nagarkatti ◽  
Mitzi Nagarkatti
Keyword(s):  
Gene Expression ◽  
T Cell ◽  
Cell Transformation ◽  
Cytokine Gene Expression ◽  
Cytokine Gene

In Vivo Cytokine Gene Expression in Various T Cell Subsets of the Autoimmune MRL/Mp-lpr/lpr Mouse

Autoimmunity ◽  
1994 ◽  
Vol 17 (1) ◽  
pp. 49-57 ◽  
Author(s):  
K. Mori ◽  
S. Kobayashi ◽  
M. Inobe ◽  
W. Y. Jia ◽  
M. Tamakosh ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cell ◽  
T Cell Subsets ◽  
Cytokine Gene Expression ◽  
Cytokine Gene

In vivo cytokine gene expression in T cell subsets of the autoimmune MRL/Mp-lpr/lpr mouse

1990 ◽  
Vol 20 (1) ◽  
pp. 163-170 ◽  
Author(s):  
Lesley J. Murray ◽  
Rozanne Lee ◽  
Christine Martens
Keyword(s):  
Gene Expression ◽  
T Cell ◽  
T Cell Subsets ◽  
Cytokine Gene Expression ◽  
Cytokine Gene

scholarly journals Anti-tumor necrosis factor modulates anti-CD3-triggered T cell cytokine gene expression in vivo.

1994 ◽  
Vol 93 (5) ◽  
pp. 2189-2196 ◽  
Author(s):  
C Ferran ◽  
F Dautry ◽  
S Mérite ◽  
K Sheehan ◽  
R Schreiber ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cell ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Cytokine Gene Expression ◽  
Cytokine Gene ◽  
Necrosis Factor

scholarly journals Overexpression of mitogen-activated protein kinase (ERK1) enhances T- cell cytokine gene expression: role of AP1, NF-AT, and NF-KB

Blood ◽  
1993 ◽  
Vol 82 (8) ◽  
pp. 2470-2477 ◽  
Author(s):  
JH Park ◽  
L Levitt
Keyword(s):  
Gene Expression ◽  
T Cell ◽  
Dna Binding ◽  
Map Kinase ◽  
Binding Activity ◽  
Cytokine Gene Expression ◽  
Cytokine Gene ◽  
Dna Binding Activity ◽  
Mitogen Activated Protein

Abstract Transfected Jurkat cells overexpressing extracellular signal-regulated kinase (ERK1), also referred to as mitogen-activated protein (MAP) kinase, were selected by Western blotting assay using anti-ERK1 and antiphosphotyrosine antibodies in combination with a functional MAP kinase assay. We then asked whether enhanced ERK1 expression had any effect on induction of T-cell cytokine genes. The results show that overexpression of ERK1 enhances expression of T-cell interleukin-2 (IL- 2), IL-3, and granulocyte-macrophage colony-stimulating factor mRNA; no change was seen in expression of the alpha-actin gene. DNA-binding activities of the transcription factors AP1, NF-AT, and NF-kB were specifically increased twofold to fourfold in ERK1-overexpressing clones relative to nontransformed or vector-transformed cells, whereas no enhancement of CK1-CK2 protein DNA binding activity was detected after ERK1 overexpression. Additionally, increased NF-AT DNA binding activity was associated with functional enhancement of NF-AT transactivating activity in ERK1-overexpressing cells. These results provide direct evidence for the role of MAP kinase in the regulation of cytokine gene expression and indicate that such regulation is likely mediated through the enhanced DNA binding activity of specific nuclear transcription factors.

KINETICS OF T CELL CYTOKINE GENE EXPRESSION IN GERBILS AFTER A PRIMARY SUBCUTANEOUS BRUGIA PAHANGI INFECTION

2005 ◽  
Vol 91 (2) ◽  
pp. 264-268 ◽  
Author(s):  
S. R. Chirgwin ◽  
U. R. Rao ◽  
Z. Mai ◽  
S. U. Coleman ◽  
J. M. Nowling ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cell ◽  
Cytokine Gene Expression ◽  
Cytokine Gene ◽  
Brugia Pahangi ◽  
Kinetics Of
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