Mutations of Myocardial Mitochondrial DNA in Diabetic Patients

1995 ◽  
pp. 59-66 ◽  
Author(s):  
Nobuakira Takeda ◽  
Akira Tanamura ◽  
Takaaki Iwai ◽  
Yuusaku Hayashi ◽  
Satoko Nomura
Keyword(s):  
Mitochondrial Dna ◽  
Diabetic Patients

scholarly journals Prevalence of 15 mitochondrial DNA mutations among type 2 diabetic patients with or without clinical characteristics of maternally inherited diabetes and deafness

2008 ◽  
Vol 52 (8) ◽  
pp. 1228-1235 ◽  
Author(s):  
Daisy Crispim ◽  
Aline A. F. Estivalet ◽  
Israel Roisenberg ◽  
Jorge L. Gross ◽  
Luis H. Canani
Keyword(s):  
Type 2 Diabetes ◽  
Mitochondrial Dna ◽  
Classical Type ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Diabetes Group ◽  
Mtdna Mutations ◽  
Type 2 Diabetic ◽  
Inherited Diabetes

The aim of the present study is to investigate the prevalence of ten described mitochondrial DNA (mtDNA) mutations in patients with type 2 diabetes, and search for new mutations in four mtDNA genes in a subgroup of patients with characteristics of maternally inherited diabetes and deafness (MIDD). These mutations were investigated in 407 type 2 diabetic patients without characteristics of mitochondrial diabetes ("classical" type 2 diabetes group) and in 38 type 2 diabetic patients with characteristics suggestive of MIDD. Through sequencing of four mtDNA genes in MIDD patients, we selected five others potentially pathogenic mutations that were also screened in the remaining patients. Overall, the frequency of the fifteen analyzed mutations was 36.84% in the MIDD group and 2.45% in the "classical" type 2 diabetes group (p < 0.001). In conclusion, our study reinforces the importance of mtDNA mutations in the pathogenesis of MIDD.

Increased Oxidative Damage with Altered Antioxidative Status in Type 2 Diabetic Patients Harboring the 16189 T to C Variant of Mitochondrial DNA

2005 ◽  
Vol 1042 (1) ◽  
pp. 64-69 ◽  
Author(s):  
TSU-KUNG LIN ◽  
SHANG-DER CHEN ◽  
PEI-WEN WANG ◽  
YAU-HUEI WEI ◽  
CHENG-FENG LEE ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Oxidative Damage ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Antioxidative Status ◽  
Type 2 Diabetic

scholarly journals Peripheral Blood Mitochondrial DNA Content Is Related to Insulin Sensitivity in Offspring of Type 2 Diabetic Patients

Diabetes Care ◽  
2001 ◽  
Vol 24 (5) ◽  
pp. 865-869 ◽  
Author(s):  
J. Song ◽  
J. Y. Oh ◽  
Y.-A. Sung ◽  
Y. K. Pak ◽  
K. S. Park ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Insulin Sensitivity ◽  
Dna Content ◽  
Peripheral Blood ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Mitochondrial Dna Content ◽  
Type 2 Diabetic

scholarly journals Depletion of mitochondrial DNA alters glucose metabolism in SK-Hep1 cells

2001 ◽  
Vol 280 (6) ◽  
pp. E1007-E1014 ◽  
Author(s):  
Kyu-Sang Park ◽  
Kyung-Jay Nam ◽  
Jun-Woo Kim ◽  
Youn-Bok Lee ◽  
Chang-Yeop Han ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Glucose Metabolism ◽  
Nuclear Dna ◽  
Glucose Transporters ◽  
Diabetic Patients ◽  
Human Hepatoma Cells ◽  
Metabolizing Enzymes ◽  
Atp Production ◽  
Protein Levels

Maternally inherited mitochondrial DNA (mtDNA) has been suggested to be a genetic factor for diabetes. Reports have shown a decrease of mtDNA content in tissues of diabetic patients. We investigated the effects of mtDNA depletion on glucose metabolism by use of ρ0 SK-Hep1 human hepatoma cells, whose mtDNA was depleted by long-term exposure to ethidium bromide. The ρ0 cells failed to hyperpolarize mitochondrial membrane potential in response to glucose stimulation. Intracellular ATP content, glucose-stimulated ATP production, glucose uptake, steady-state mRNA and protein levels of glucose transporters, and cellular activities of glucose-metabolizing enzymes were decreased in ρ0 cells compared with parental ρ+ cells. Our results suggest that the quantitative reduction of mtDNA may suppress the expression of nuclear DNA-encoded glucose transporters and enzymes of glucose metabolism. Thus this may lead to diabetic status, such as decreased ATP production and glucose utilization.

Clinical features of diabetic patients with 0.01–0.1% heteroplasmy A3243G mutation in leukocyte mitochondrial DNA

2001 ◽  
Vol 54 (3) ◽  
pp. 215-217 ◽  
Author(s):  
M Iwase ◽  
D Gotoh ◽  
M Urata ◽  
D Kang ◽  
N Hamasaki ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Clinical Features ◽  
Diabetic Patients ◽  
A3243g Mutation

Mitochondrial DNA 3243 Mutation Is Infrequent in Japanese Diabetic Patients With Auditory Disturbance

Diabetes Care ◽  
1997 ◽  
Vol 20 (11) ◽  
pp. 1800-1801 ◽  
Author(s):  
Y. Fukunaga ◽  
N. Azuma ◽  
H. Koshiyama ◽  
D. Inoue ◽  
H. Sato ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Diabetic Patients

scholarly journals Mitochondrial DNA Haplogroup JT is Related to Impaired Glycaemic Control and Renal Function in Type 2 Diabetic Patients

2018 ◽  
Vol 7 (8) ◽  
pp. 220 ◽  
Author(s):  
Noelia Diaz-Morales ◽  
Sandra Lopez-Domenech ◽  
Francesca Iannantuoni ◽  
Ester Lopez-Gallardo ◽  
Eva Sola ◽  
...  
Keyword(s):  
Renal Function ◽  
Mitochondrial Dna ◽  
Glycaemic Control ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Mtdna Haplogroups ◽  
The Impact ◽  
Type 2 Diabetic ◽  
Mtdna Haplogroup

The association between mitochondrial DNA (mtDNA) haplogroup and risk of type 2 diabetes (T2D) is undetermined and controversial. This study aims to evaluate the impact of the main mtDNA haplogroups on glycaemic control and renal function in a Spanish population of 303 T2D patients and 153 healthy controls. Anthropometrical and metabolic parameters were assessed and mtDNA haplogroup was determined in each individual. Distribution of the different haplogroups was similar in diabetic and healthy populations and, as expected, T2D patients showed poorer glycaemic control and renal function than controls. T2D patients belonging to the JT haplogroup (polymorphism m.4216T>C) displayed statistically significant higher levels of fasting glucose and HbA1c than those of the other haplogroups, suggesting a poorer glycaemic control. Furthermore, diabetic patients with the JT haplogroup showed a worse kidney function than those with other haplogroups, evident by higher levels of serum creatinine, lower estimated glomerular filtration rate (eGFR), and slightly higher (although not statistically significant) urinary albumin-to-creatinine ratio. Our results suggest that JT haplogroup (in particular, change at position 4216 of the mtDNA) is associated with poorer glycaemic control in T2D, which can trigger the development of diabetic nephropathy.

Association between HLA and islet cell antibodies in diabetic patients with a mitochondrial DNA mutation at base pair 3243

Diabetologia ◽  
1996 ◽  
Vol 39 (10) ◽  
pp. 1196-1200 ◽  
Author(s):  
T. Kobayashi ◽  
Y. Oka ◽  
H. Katagiri ◽  
A. Falorni ◽  
A. Kasuga ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Base Pair ◽  
Islet Cell ◽  
Islet Cell Antibodies ◽  
Diabetic Patients ◽  
Mitochondrial Dna Mutation ◽  
Dna Mutation
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