Functional Maturation of B Cell Repertoire Expression

Antibodies ◽  
1987 ◽  
pp. 61-69
Author(s):  
Barbara G. Froscher ◽  
Norman R. Klinman
Keyword(s):  
B Cell ◽  
Cell Repertoire ◽  
Functional Maturation ◽  
B Cell Repertoire

Selection of the expressed B cell repertoire by infusion of normal immunoglobulin G in a patient with autoimmune thyroiditis

1993 ◽  
Vol 23 (11) ◽  
pp. 2945-2950 ◽  
Author(s):  
Gilles Dietrich ◽  
Francisco J. Varela ◽  
Vincent Hurez ◽  
Majida Bouanani ◽  
Michel D. Kazatchkine
Keyword(s):  
B Cell ◽  
Immunoglobulin G ◽  
Autoimmune Thyroiditis ◽  
Cell Repertoire ◽  
B Cell Repertoire ◽  
Selection Of

Monoclonal CD5+ and CD5- B-lymphocyte expansions are frequent in the peripheral blood of the elderly

Blood ◽  
2004 ◽  
Vol 103 (6) ◽  
pp. 2337-2342 ◽  
Author(s):  
Paolo Ghia ◽  
Giuseppina Prato ◽  
Cristina Scielzo ◽  
Stefania Stella ◽  
Massimo Geuna ◽  
...  
Keyword(s):  
B Cell ◽  
Peripheral Blood ◽  
B Lymphocyte ◽  
The Elderly ◽  
Lymphocytic Leukemia ◽  
Pcr Analysis ◽  
Cell Repertoire ◽  
Healthy Elderly ◽  
B Cell Repertoire ◽  
Igh Genes

Abstract The responsiveness and diversity of peripheral B-cell repertoire decreases with age, possibly because of B-cell clonal expansions, as suggested by the incidence of serum monoclonal immunoglobulins and of monoclonal chronic lymphocytic leukemia (CLL)–like B lymphocytes in clinically silent adults. We phenotyped peripheral blood cells from 500 healthy subjects older than 65 years with no history or suspicion of malignancies and no evidence of lymphocytosis. In 19 cases (3.8%) a κ/λ ratio of more than 3:1 or less than 1:3 was found: 9 were CD5+, CD19+, CD23+, CD20low, CD79blow, sIglow (classic CLL-like phenotype); 3 were CD5+, CD19+, CD23+, CD20high, CD79blow, sIglow (atypical CLL-like), and 7 were CD5-, CD19+, CD20high, CD23-, CD79bbright, FMC7+, sIgbright (non–CLL-like). In 2 subjects, 2 phenotypically distinct unrelated clones were concomitantly evident. No cases were CD10+. Polymerase chain reaction (PCR) analysis demonstrated a monoclonal rearrangement of IgH genes in 15 of 19 cases. No bcl-1 or bcl-2 rearrangements were detected. Using a gating strategy based on CD20/CD5/CD79 expression, 13 additional CLL-like B-cell clones were identified (cumulative frequency of classic CLL-like: 5.5%). Thus, phenotypically heterogeneous monoclonal B-lymphocyte expansions are common among healthy elderly individuals and are not limited to classic CLL-like clones but may have the phenotypic features of different chronic lymphoproliferative disorders, involving also CD5- B cells.

Analysis of Monoclonal Rheumatoid Factors obtained from the B-Cell Repertoire in Rheumatoid Arthritis

1992 ◽  
Vol 35 (2) ◽  
pp. 149-157 ◽  
Author(s):  
M. ABDERRAZIK ◽  
M. MOYNIER ◽  
R JEFFFRIS ◽  
R. A. K. MAGEED ◽  
B. COMBE ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
B Cell ◽  
Rheumatoid Factors ◽  
Cell Repertoire ◽  
B Cell Repertoire

scholarly journals Modified neonatal B-cell repertoire as a consequence of rituximab administration to a pregnant woman

Rheumatology ◽  
2012 ◽  
Vol 52 (2) ◽  
pp. 405-406 ◽  
Author(s):  
M. U. Martinez-Martinez ◽  
L. Baranda-Candido ◽  
R. Gonzalez-Amaro ◽  
O. Perez-Ramirez ◽  
C. Abud-Mendoza
Keyword(s):  
Pregnant Woman ◽  
B Cell ◽  
Cell Repertoire ◽  
B Cell Repertoire

scholarly journals The landscape and diagnostic potential of T and B cell repertoire in Immunoglobulin A Nephropathy

2019 ◽  
Vol 97 ◽  
pp. 100-107 ◽  
Author(s):  
Chen Huang ◽  
Xuemei Li ◽  
Jinghua Wu ◽  
Wei Zhang ◽  
Shiren Sun ◽  
...  
Keyword(s):  
B Cell ◽  
Immunoglobulin A ◽  
Immunoglobulin A Nephropathy ◽  
Cell Repertoire ◽  
B Cell Repertoire ◽  
Diagnostic Potential

scholarly journals Aging-Dependent Exclusion of Antigen-Inexperienced Cells from the Peripheral B Cell Repertoire

2002 ◽  
Vol 168 (10) ◽  
pp. 5014-5023 ◽  
Author(s):  
Sara A. Johnson ◽  
Stephen J. Rozzo ◽  
John C. Cambier
Keyword(s):  
B Cell ◽  
Cell Repertoire ◽  
B Cell Repertoire
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