Diphosphonates Mode of Action and Clinical Applications

1977 ◽  
pp. 279-289 ◽  
Author(s):  
H. Fleisch ◽  
D. Fast ◽  
R. Rizzoli ◽  
U. Trechsel ◽  
J.-P. Bonjour
Keyword(s):  
Mode Of Action ◽  
Clinical Applications

Netra Pratisarana - Effective result with a simple procedure

2017 ◽  
Vol 2 (05) ◽  
Author(s):  
Shobha C. M. ◽  
Hamsaveni .
Keyword(s):  
Mode Of Action ◽  
Chronic Conditions ◽  
Simple Procedure ◽  
Clinical Applications ◽  
Acute Management ◽  
Sensitive Structure ◽  
Cost Effect ◽  
Effective Result

Pratisarana (rubbing) has been explained as Sthanika Chikitsa. Pratisarana is done, where Shastra Karma has a limitation to be used because of the sensitive surgical sight. “Hastameva Pradana Yantra”, Hasta (hand) has been used to carry out the procedure with various Lekhana Dravyas on such a delicate and sensitive structure with the expectation to cease the deep rooted / recurring / stubborn conditions. The importance of Pratisarana in Netra Roga as local ocular therapeutic/ surgery and its measures is immense into the present day in any chronic conditions as acute management due to its vast advantages, cost effect, availability of the drugs and procedure. In this area of presentation a brief overview on Pratisarana, its variants, Indications, clinical applications and rationality of the drugs used which are commonly available and probable mode of action will be convened to increase the confident level and make more ease to practice as an acute management to achieve success clinically.

Radiosurgery: A Forgotten Tool?

Dental Update ◽  
2021 ◽  
Vol 48 (5) ◽  
pp. 369-376
Author(s):  
Timothy Brown ◽  
Martin Donachie
Keyword(s):  
Mode Of Action ◽  
Clinical Relevance ◽  
Clinical Applications ◽  
Field Variation ◽  
Surgical Equipment ◽  
General Lack ◽  
Tissue Cutting ◽  
Dental Lasers ◽  
Surgical Field ◽  
Lack Of Knowledge

Radiosurgery allows precise tissue cutting with simultaneous haemostasis, providing a clearer surgical field. Variation in waveform, power settings and handpiece tip shape allow for a wide variety of clinical applications, making it one of the most versatile pieces of surgical equipment in the dentist's arsenal. However, it is one of the most underused, and probably misunderstood, areas of surgery in dentistry. This may be due to conflicting literature concerning healing, overshadowing of the value of the technique by interest in dental lasers, misuse of terminology and a general lack of knowledge regarding the science underpinning its action. CPD/Clinical Relevance: This article aims to outline the mode of action, adjustable parameters and considerations for the safe use of radiosurgery alongside clinical examples of its applications.

Effects of 5-5'-Diphenyl-2-thiohydantoin (DPTH) and Thyroxine on the Ultrastructure and Chemical Composition of Rat Liver

1971 ◽  
Vol 29 ◽  
pp. 570-571
Author(s):  
E. A. Elfont ◽  
R. B. Tobin ◽  
D. G. Colton ◽  
M. A. Mehlman
Keyword(s):  
Chemical Composition ◽  
Rat Liver ◽  
Future Study ◽  
Mode Of Action ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Effective Inhibitor ◽  
Biochemical Effects ◽  
Glycerophosphate Dehydrogenase ◽  
Stimulation Of

Summary5,-5'-diphenyl-2-thiohydantoin (DPTH) is an effective inhibitor of thyroxine (T4) stimulation of α-glycerophosphate dehydrogenase in rat liver mitochondria. Because this finding indicated a possible tool for future study of the mode of action of thyroxine, the ultrastructural and biochemical effects of DPTH and/or thyroxine on rat liver mere investigated.Rats were fed either standard or DPTH (0.06%) diet for 30 days before T4 (250 ug/kg/day) was injected. Injection of T4 occurred daily for 10 days prior to sacrifice. After removal of the liver and kidneys, part of the tissue was frozen at -50°C for later biocheailcal analyses, while the rest was prefixed in buffered 3.5X glutaraldehyde (390 mOs) and post-fixed in buffered 1Z OsO4 (376 mOs). Tissues were embedded in Araldlte 502 and the sections examined in a Zeiss EM 9S.Hepatocytes from hyperthyroid rats (Fig. 2) demonstrated enlarged and more numerous mitochondria than those of controls (Fig. 1). Glycogen was almost totally absent from the cytoplasm of the T4-treated rats.

Specimen Preparation for Clinical Applications of X-Ray Microanalysis

1990 ◽  
Vol 48 (2) ◽  
pp. 328-329
Author(s):  
J.D. Shelburne ◽  
G.M. Roomans
Keyword(s):  
Carbon Coating ◽  
Clinical Applications ◽  
Point Of View ◽  
Practical Significance ◽  
Sweat Test ◽  
Specimen Preparation ◽  
Tissue Preparation ◽  
X Ray ◽  
Gallbladder Stones ◽  
Clinical Problems

Proper preparative procedures are a prerequisite for the validity of the results of x-ray microanalysis of biological tissue. Clinical applications of x-ray microanalysis are often concerned with diagnostic problems and the results may have profound practical significance for the patient. From this point of view it is especially important that specimen preparation for clinical applications is carried out correctly.Some clinical problems require very little tissue preparation. Hair, nails, and kidney and gallbladder stones may be examined and analyzed after carbon coating. High levels of zinc or copper in hair may be indicative of dermatological or systemic diseases. Nail clippings may be analyzed (as an alternative to the more conventional sweat test) to confirm a diagnosis of cystic fibrosis. X-ray microanalysis in combination with scanning electron microscopy has been shown to be the most reliable method for the identification of the components of kidney or gallbladder stones.A quantitatively very important clinical application of x-ray microanalysis is the identification and quantification of asbestos and other exogenous particles in lung.

Reduction of Potassium in Kidney Proximal Tubules to Aid in Electron Probe X-Ray Microanalysis of Calcium

1985 ◽  
Vol 43 ◽  
pp. 474-475
Author(s):  
A. LeFurgey ◽  
P. Ingram ◽  
L.J. Mandel
Keyword(s):  
Smooth Muscle ◽  
Proximal Tubule ◽  
Electron Probe ◽  
Clinical Applications ◽  
Proximal Tubules ◽  
Rabbit Kidney ◽  
Target Cells ◽  
X Ray ◽  
Freeze Dried

For quantitative determination of subcellular Ca distribution by electron probe x-ray microanalysis, decreasing (and/or eliminating) the K content of the cell maximizes the ability to accurately separate the overlapping K Kß and Ca Kα peaks in the x-ray spectra. For example, rubidium has been effectively substituted for potassium in smooth muscle cells, thus giving an improvement in calcium measurements. Ouabain, a cardiac glycoside widely used in experimental and clinical applications, inhibits Na-K ATPase at the cell membrane and thus alters the cytoplasmic ion (Na,K) content of target cells. In epithelial cells primarily involved in active transport, such as the proximal tubule of the rabbit kidney, ouabain rapidly (t1/2= 2 mins) causes a decrease2 in intracellular K, but does not change intracellular total or free Ca for up to 30 mins. In the present study we have taken advantage of this effect of ouabain to determine the mitochondrial and cytoplasmic Ca content in freeze-dried cryosections of kidney proximal tubule by electron probe x-ray microanalysis.

Simple teaching aid with clinical applications

1976 ◽  
Vol 40 (2) ◽  
pp. 106-106
Author(s):  
DL Torney ◽  
HD Espinosa
Keyword(s):  
Clinical Applications ◽  
Teaching Aid

Lexical Comprehension in Young Children With Developmental Delays

1994 ◽  
Vol 3 (1) ◽  
pp. 79-88 ◽  
Author(s):  
Theresa A. Kouri
Keyword(s):  
Young Children ◽  
Developmental Delays ◽  
Normal Development ◽  
Clinical Applications ◽  
Group Status ◽  
Novel Object ◽  
Related Information ◽  
Comprehension Skills ◽  
Lexical Items ◽  
Lexical Concepts

Lexical comprehension skills were examined in 20 young children (aged 28–45 months) with developmental delays (DD) and 20 children (aged 19–34 months) with normal development (ND). Each was assigned to either a story-like script condition or a simple ostensive labeling condition in which the names of three novel object and action items were presented over two experimental sessions. During the experimental sessions, receptive knowledge of the lexical items was assessed through a series of target and generalization probes. Results indicated that all children, irrespective of group status, acquired more lexical concepts in the ostensive labeling condition than in the story narrative condition. Overall, both groups acquired more object than action words, although subjects with ND comprehended more action words than subjects with DD. More target than generalization items were also comprehended by both groups. It is concluded that young children’s comprehension of new lexical concepts is facilitated more by a context in which simple ostensive labels accompany the presentation of specific objects and actions than one in which objects and actions are surrounded by thematic and event-related information. Various clinical applications focusing on the lexical training of young children with DD are discussed.

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