Antibiotic Drug Development: Moving Forward into the Clinic

2011 ◽  
pp. 1071-1100 ◽  
Author(s):  
Jane E. Ambler ◽  
Greg G. Stone
Keyword(s):  
Drug Development ◽  
Antibiotic Drug

Pharmacokinetics I: PK-PD approaches - antibiotic drug development

2010 ◽  
pp. 143-155
Author(s):  
Sreedharan N. Sabarinath ◽  
Rajendra Pratap Singh ◽  
Hartmut Derendorf
Keyword(s):  
Drug Development ◽  
Antibiotic Drug

Active controlled studies in antibiotic drug development

2011 ◽  
Vol 10 (5) ◽  
pp. 454-460 ◽  
Author(s):  
Aaron Dane
Keyword(s):  
Drug Development ◽  
Antibiotic Drug

Pharmacokinetics I: PK-PD Approach, the Case of Antibiotic Drug Development

2016 ◽  
pp. 185-217 ◽  
Author(s):  
Sherwin K. B. Sy ◽  
Hartmut Derendorf
Keyword(s):  
Drug Development ◽  
Antibiotic Drug

Antimicrobial innovation: a current update and perspective on the antibiotic drug development pipeline

2020 ◽  
Vol 12 (22) ◽  
pp. 2035-2065
Author(s):  
Liam J Stephens ◽  
Melissa V Werrett ◽  
Adam C Sedgwick ◽  
Steven D Bull ◽  
Philip C Andrews
Keyword(s):  
Drug Development ◽  
Bacterial Infections ◽  
Treatment Options ◽  
Press Releases ◽  
Current Trends ◽  
Antibiotic Drug ◽  
If Current ◽  
Development Pipeline ◽  
Insight Into ◽  
A Current

As bacteria continue to develop resistance to our existing treatment options, antibiotic innovation remains overlooked. If current trends continue, then we could face the stark reality of a postantibiotic era, whereby routine bacterial infections could once again become deadly. In light of a warning signaled by the WHO, a number of new initiatives have been established in the hope of reinvigorating the antibiotic drug development pipeline. In this perspective, we aim to summarize some of these initiatives and funding options, as well as providing an insight into the predicament that we face. Using clinical trials data, company website information and the most recent press releases, a current update of the antibiotic drug development pipeline is also included.

scholarly journals FDA asks for input on antibiotic drug development

2013 ◽  
Vol 12 (7) ◽  
pp. 494-494 ◽  
Keyword(s):  
Drug Development ◽  
Antibiotic Drug

Tu1860 - A Novel Octapeptide as a Promising Candidate for Antibiotic Drug Development and Host Derived Microbiome Regulation

2018 ◽  
Vol 154 (6) ◽  
pp. S-1040 ◽  
Author(s):  
Judith Wendler ◽  
Björn O. Schröder ◽  
Dirk Ehmann ◽  
Christina Braunsdorf ◽  
Nisar P. Malek ◽  
...  
Keyword(s):  
Drug Development ◽  
Promising Candidate ◽  
Antibiotic Drug

Rational approaches towards inorganic and organometallic antibacterials

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Jeannine Hess
Keyword(s):  
Drug Discovery ◽  
Drug Development ◽  
Organometallic Compounds ◽  
Mechanisms Of Action ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Drug Resistant Bacteria ◽  
Alternative Approach ◽  
Antibiotic Drug ◽  
Selection Of

Abstract The occurrence of drug-resistant bacteria is drastically rising and new and effective antibiotic classes are urgently needed. However, most of the compounds in development are minor modifications of previously used drugs to which bacteria can easily develop resistance. The investigation of inorganic and organometallic compounds as antibiotics is an alternative approach that holds great promises due to the ability of such molecules to trigger metal-specific mechanisms of action, which results in lethal consequences for pathogens. In this review, a selection of concepts to rationally design inorganic and organometallic antibiotics is discussed, highlighting their advantages by comparing them to classical drug discovery programmes. The review concludes with a short perspective for the future of antibiotic drug development and the role metal-based compounds will play in the field.

Regulatory Incentives for Antibiotic Drug Development: A Review of Recent Proposals

2016 ◽  
Vol 24 (24) ◽  
pp. 6446-6451 ◽  
Author(s):  
Michael S. Sinha ◽  
Aaron S. Kesselheim
Keyword(s):  
Drug Development ◽  
Antibiotic Drug ◽  
Regulatory Incentives
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