Androgen Receptor Regulation of Serum Response Factor Signaling in Prostate Cancer

2013 ◽  
pp. 257-271
Author(s):  
Alissa R. Verone ◽  
Hannelore V. Heemers
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Serum Response Factor ◽  
Receptor Regulation ◽  
Response Factor ◽  
Serum Response

scholarly journals Relationship between serum response factor and androgen receptor in prostate cancer

The Prostate ◽  
2015 ◽  
Vol 75 (15) ◽  
pp. 1704-1717 ◽  
Author(s):  
Maria Prencipe ◽  
Amanda O'Neill ◽  
Gillian O'Hurley ◽  
Lan K. Nguyen ◽  
Aurelie Fabre ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Serum Response Factor ◽  
Response Factor ◽  
Serum Response

scholarly journals FGFR-4 Arg388 Enhances Prostate Cancer Progression via Extracellular Signal–Related Kinase and Serum Response Factor Signaling

2011 ◽  
Vol 17 (13) ◽  
pp. 4355-4366 ◽  
Author(s):  
Wendong Yu ◽  
Shu Feng ◽  
Olga Dakhova ◽  
Chad J. Creighton ◽  
Yi Cai ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Serum Response Factor ◽  
Response Factor ◽  
Prostate Cancer Progression ◽  
Extracellular Signal ◽  
Serum Response

scholarly journals Protein Kinase N1 control of androgen-responsive serum response factor action provides rationale for novel prostate cancer treatment strategy

Oncogene ◽  
2019 ◽  
Vol 38 (23) ◽  
pp. 4496-4511
Author(s):  
Varadha Balaji Venkadakrishnan ◽  
Adam D. DePriest ◽  
Sangeeta Kumari ◽  
Dhirodatta Senapati ◽  
Salma Ben-Salem ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Protein Kinase ◽  
Cancer Treatment ◽  
Treatment Strategy ◽  
Serum Response Factor ◽  
Response Factor ◽  
Prostate Cancer Treatment ◽  
Serum Response

scholarly journals Androgen-responsive Serum Response Factor target genes regulate prostate cancer cell migration

2013 ◽  
Vol 34 (8) ◽  
pp. 1737-1746 ◽  
Author(s):  
A. R. Verone ◽  
K. Duncan ◽  
A. Godoy ◽  
N. Yadav ◽  
A. Bakin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Target Genes ◽  
Serum Response Factor ◽  
Prostate Cancer Cell ◽  
Response Factor ◽  
Cancer Cell Migration ◽  
Serum Response

scholarly journals Inhibition of Serum Response Factor Improves Response to Enzalutamide in Prostate Cancer

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3540
Author(s):  
R. William Watson ◽  
Haleema Azam ◽  
Claudia Aura ◽  
Niamh Russell ◽  
Janet McCormack ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Serum Response Factor ◽  
Specific Antigen ◽  
Xenograft Model ◽  
Tumour Volume ◽  
Lead Target ◽  
Response Factor ◽  
Serum Response

Castrate-resistant prostate cancer (CRPC) is challenging to treat with the androgen receptor (AR), the main target and key focus of resistance. Understanding the mechanisms of AR interaction with co-regulators will identify new therapeutic targets to overcome AR resistance mechanisms. We previously identified the serum response factor (SRF) as a lead target in an in vitro model of CRPC and showed that SRF expression in tissues of CRPC patients was associated with shorter survival. Here, we tested SRF inhibition in vitro and in vivo to assess SRF as a potential target in CRPC. Inhibition of SRF with the small-molecule inhibitor CCG1423 resulted in enhanced response to enzalutamide in vitro and reduced tumour volume of LuCaP 35CR, a CRPC patient-derived xenograft model. Nuclear localisation of AR post-CCG1423 was significantly decreased and was associated with decreased α-tubulin acetylation in vitro and decreased prostate specific antigen (PSA) levels in vivo. SRF immunoreactivity was tested in metastatic tissues from CRPC patients to investigate its role in enzalutamide response. Kaplan–Meier curves showed that high SRF expression was associated with shorter response to enzalutamide. Our study supports the use of SRF inhibitors to improve response to enzalutamide.

scholarly journals The analysis of serum response factor expression in bone and soft tissue prostate cancer metastases

The Prostate ◽  
2014 ◽  
Vol 74 (3) ◽  
pp. 306-313 ◽  
Author(s):  
Gillian O'Hurley ◽  
Maria Prencipe ◽  
Dara Lundon ◽  
Amanda O'Neill ◽  
Susie Boyce ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Soft Tissue ◽  
Serum Response Factor ◽  
Response Factor ◽  
Cancer Metastases ◽  
Factor Expression ◽  
Serum Response

scholarly journals Role of serum response factor expression in prostate cancer biochemical recurrence

The Prostate ◽  
2018 ◽  
Vol 78 (10) ◽  
pp. 724-730 ◽  
Author(s):  
Maria Prencipe ◽  
Aurelie Fabre ◽  
Thomas Brendan Murphy ◽  
Eszter Vargyas ◽  
Amanda O'Neill ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Biochemical Recurrence ◽  
Serum Response Factor ◽  
Response Factor ◽  
Factor Expression ◽  
Serum Response
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