scholarly journals Protein Kinase N1 control of androgen-responsive serum response factor action provides rationale for novel prostate cancer treatment strategy

Oncogene ◽  
2019 ◽  
Vol 38 (23) ◽  
pp. 4496-4511
Author(s):  
Varadha Balaji Venkadakrishnan ◽  
Adam D. DePriest ◽  
Sangeeta Kumari ◽  
Dhirodatta Senapati ◽  
Salma Ben-Salem ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Protein Kinase ◽  
Cancer Treatment ◽  
Treatment Strategy ◽  
Serum Response Factor ◽  
Response Factor ◽  
Prostate Cancer Treatment ◽  
Serum Response

Inhibition of c-fos transcription and phosphorylation of the serum response factor by an inhibitor of phospholipase C-type reactions

1990 ◽  
Vol 10 (10) ◽  
pp. 5558-5561
Author(s):  
G Schalasta ◽  
C Doppler
Keyword(s):  
Transcription Factor ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Phospholipase C ◽  
Transcriptional Activation ◽  
Serum Response Factor ◽  
Response Factor ◽  
Kinase C ◽  
Beta Actin ◽  
Serum Response

Phospholipase C activity is necessary for transcriptional c-fos activation by providing diacylglycerol as an activator of protein kinase C. We found that transcriptional activation of c-fos and the phosphorylation of its major transcription factor were inhibited by tricyclodecan-9-yl xanthogenate, which blocks phospholipase C-type reactions. Transcription of the c-ras and beta-actin genes in the same cells remained unaffected.

scholarly journals Androgen-responsive Serum Response Factor target genes regulate prostate cancer cell migration

2013 ◽  
Vol 34 (8) ◽  
pp. 1737-1746 ◽  
Author(s):  
A. R. Verone ◽  
K. Duncan ◽  
A. Godoy ◽  
N. Yadav ◽  
A. Bakin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Target Genes ◽  
Serum Response Factor ◽  
Prostate Cancer Cell ◽  
Response Factor ◽  
Cancer Cell Migration ◽  
Serum Response
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