Selenoproteins of the glutathione system

The Effects of Quercetin to Glutathione System in the Bacterial-Immune Periodontitis Development

Ukraïnsʹkij žurnal medicini bìologìï ta sportu ◽

10.26693/jmbs03.04.020 ◽

2018 ◽

Vol 3 (4) ◽

pp. 20-24

Author(s):

A. Ye. Demkovych ◽

◽

Yu. I. Bondarenko ◽

O. O. Stakhanska

Keyword(s):

Glutathione System

Download Full-text

Assessment of indicators of nervous and emotional stress in medical center personnel depending on the characteristics of their professional activity

Russian Journal of Occupational Health and Industrial Ecology ◽

10.31089/1026-9428-2020-60-10-650-657 ◽

2020 ◽

Vol 60 (10) ◽

pp. 650-657

Author(s):

Irina V. Fedotova ◽

Tatyana N. Vasilyeva ◽

Tatyana V. Blinova ◽

Irina A. Umnyagina ◽

Yuliya V. Lyapina ◽

...

Keyword(s):

Oxidative Stress ◽

Emotional Stress ◽

Functional State ◽

Working Conditions ◽

Medical Staff ◽

Medical Center ◽

The Body ◽

Office Workers ◽

Glutathione System ◽

Medical Centers

Introduction. Digital technologies are actively used in the work of specialists of medical centers of various profiles, which causes the impact on employees of a number of professional factors that determine the characteristics of their work. The aim of the study is to evaluate the influence of professional factors on the functional state of the employees' body and the glutathione system as an objective indicator of stress based on the analysis of the subjective perception of the medical center employees of the specifics of working with personal computers and psychophysiological testing. Materials and methods. The study involved 109 specialists of medical centers (25 ophthalmologists, 31 representatives of the secondary medical staff - nurses and paramedics, 53 office employees). The anonymous survey concerned the assessment of working conditions and their impact on the functional state of the body of the respondents. Performance and stress tolerance indicators were evaluated using three standard questionnaires. The study of 66 subjects' levels of glutathione in the blood: total, reduced, oxidized and the ratio of reduced and oxidized - was used to analyze the relationship of the neuro-emotional nature of labor with the reaction of oxidative stress. Statistical processing of the obtained data was carried out using traditional methods of variation statistics and calculating the value of the odds ratio (OR) with a 95% confidence interval (CI). Results. The survey revealed a significant proportion of people in all groups of respondents who constantly use computer technology in their work. Describing the quality of the processed information, doctors more than representatives of other groups note its complexity, importance, negative emotional color, a high degree of responsibility and tension. Doctors more often than average medical staff and office workers associate the manifestation of fatigue with an uncomfortable state of the visual organ, nervous system, and musculoskeletal system. The subjects showed reduced performance and stress tolerance with the most pronounced negative trends in the group of doctors. Changes in the glutathione system were detected, indicating the presence of oxidative stress in 40% of ophthalmologists and office workers, and in half of nurses. Conclusions. The work of specialists of medical centers of various profiles in accordance with their assessment is characterized by high nervous and emotional stress, due to the need to process a significant amount of complex and important professionally significant information. Subjectively noted by respondents the influence of working conditions on the functional state of the body is confirmed by indicators of the glutathione system, which can be used as indicators of nervous and emotional stress.

Download Full-text

The role of the glutathione system during dehydration of Boea hygroscopica

Physiologia Plantarum ◽

10.1111/j.1399-3054.1997.tb03426.x ◽

1997 ◽

Vol 99 (1) ◽

pp. 23-30 ◽

Cited By ~ 67

Author(s):

F. Navari-Izzo ◽

S. Meneguzzo ◽

B. Loggini ◽

C. Vazzana ◽

C. L. M. Sgherri

Keyword(s):

Glutathione System

Download Full-text

Ageing-induced changes in glutathione system of sunflower seeds

Physiologia Plantarum ◽

10.1111/j.1399-3054.1997.tb01067.x ◽

1997 ◽

Vol 101 (4) ◽

pp. 807-814 ◽

Cited By ~ 14

Author(s):

M. Torres ◽

M. Paula ◽

M. Perez-Otaola ◽

M. Darder ◽

G. Frutos ◽

...

Keyword(s):

Glutathione System ◽

Sunflower Seeds ◽

Induced Changes

Download Full-text

Influence of vitamin E treatment on glutathione system after renal ischemia in immature and adult rats

Experimental and Toxicologic Pathology ◽

10.1016/s0940-2993(97)80072-3 ◽

1997 ◽

Vol 49 (1-2) ◽

pp. 81-86 ◽

Cited By ~ 2

Author(s):

Ch. Fleck ◽

D. Haubold ◽

T. Hillmann ◽

H. Bräunlich

Keyword(s):

Vitamin E ◽

Renal Ischemia ◽

Glutathione System ◽

Adult Rats

Download Full-text

Role of Heat Shock Protein 27 in Regulation of Glutathione System and Apoptosis of Jurkat Tumor Cells and Blood Lymphocytes

Bulletin of Experimental Biology and Medicine ◽

10.1007/s10517-015-2766-3 ◽

2015 ◽

Vol 158 (3) ◽

pp. 377-379 ◽

Cited By ~ 6

Author(s):

N. V. Ryazantseva ◽

E. A. Stepovaya ◽

O. L. Nosareva ◽

E. V. Konovalova ◽

D. S. Orlov ◽

...

Keyword(s):

Heat Shock ◽

Heat Shock Protein ◽

Tumor Cells ◽

Heat Shock Protein 27 ◽

Glutathione System ◽

Blood Lymphocytes

Download Full-text

Biological and medical value of antioxidant protection system of the human body

Медицина сьогодні і завтра ◽

10.35339/msz.2021.90.01.03 ◽

2021 ◽

Vol 90 (1) ◽

pp. 21-32

Author(s):

O.M. Kovalyova ◽

T.M. Pasiieshvili

Keyword(s):

Superoxide Dismutase ◽

Antioxidant System ◽

Human Body ◽

Manganese Superoxide Dismutase ◽

Glutathione Transferase ◽

Chemical Properties ◽

Antioxidant Protection ◽

Glutathione System ◽

Radical Oxidation ◽

Manganese Superoxide

The article is devoted to the antioxidant system of the human body in the context of biological and medical significance. The classification of antioxidants in terms of their physical and chemical properties, bioorganic compounds, biochemical effects, mechanisms of implementation of antioxidant protection is presented. The given processes of extreme radical oxidation and mechanisms of antioxidant defense in physiological and pathological conditions. The characteristics of the components of the glutathione system, namely glutathione and enzymes – glutathione peroxidase, glutathione reductase and glutathione transferase are presented. Much attention is paid to manganese superoxide dismutase, an antiradical defense enzyme, as a fundamental regulator of cell proliferation, a mediator of metabolism and apoptosis. Interpretation of changes in the antioxidant enzyme of mitochondrial origin from a prognostic point of view is interpreted on the basis of the results of clinical observations carried out by scientists in various human diseases. The expediency of determining manganese superoxide dismutase in clinical practice for the diagnostic search for the direction of the pathological process, the timely detection of complications and the appointment of adequate therapy is emphasized. Keywords: antioxidant system, classification, glutathione system, manganese superoxide dismutase.

Download Full-text

Comparative analysis of the effect of epibrassinolide and 6-benzylaminopurine on the key components of the glutathione complex in the roots of wheat seedling under salinity.

Biomics ◽

10.31301/2221-6197.bmcs.2021-3 ◽

2021 ◽

Vol 13 (1) ◽

pp. 20-26

Author(s):

D.R. Maslennikova ◽

F.M. Shakirova

Keyword(s):

Comparative Analysis ◽

Wheat Seedling ◽

Glutathione System ◽

Glutathione S Transferase ◽

Wheat Seedlings ◽

Comparable Level ◽

Endogenous Cytokinins ◽

Main Components ◽

First Time

The study carried out a comparative analysis of the effect of 24 epibrassinolide (EB) and 6-benzylaminopurine (BAP) on the growth and state of the main components of the glutathione system in the roots of wheat seedlings under the action of 2% NaCl, which for the first time revealed the ability of these phytohormones to similarly stabilize stress-induced decrease GSH / GSSG ratio, positively regulate the activity of glutathione reductase and glutathione-S-transferase. A comparable level of protective effect of BAP and EB on root length was revealed. The data obtained indicate that endogenous cytokinins may play the role of hormonal intermediates in the implementation of the protective.

Download Full-text