Selection, Recombination, and DNA Polymorphism in Drosophila

1994 ◽  
pp. 46-56 ◽  
Author(s):  
Charles F. Aquadro ◽  
David J. Begun ◽  
Eric C. Kindahl
Keyword(s):  
Dna Polymorphism

Genetic analysis of Y chromosome and mitochondrial DNA polymorphism of Mulam ethnic group in Guangxi, China

2013 ◽  
Vol 35 (2) ◽  
pp. 168-174 ◽  
Author(s):  
Xiao-Qing WANG ◽  
Chuan-Chao WANG ◽  
Qiong-Ying DENG ◽  
Hui LI
Keyword(s):  
Mitochondrial Dna ◽  
Genetic Analysis ◽  
Ethnic Group ◽  
Y Chromosome ◽  
Dna Polymorphism ◽  
Mitochondrial Dna Polymorphism

scholarly journals The effect of change in population size on DNA polymorphism.

Genetics ◽  
1989 ◽  
Vol 123 (3) ◽  
pp. 597-601 ◽  
Author(s):  
F Tajima
Keyword(s):  
Population Size ◽  
Dna Sequences ◽  
Dna Polymorphism ◽  
Population Bottleneck ◽  
Expected Number ◽  
Original Population ◽  
Current Population ◽  
Segregating Sites

Abstract The expected number of segregating sites and the expectation of the average number of nucleotide differences among DNA sequences randomly sampled from a population, which is not in equilibrium, have been developed. The results obtained indicate that, in the case where the population size has changed drastically, the number of segregating sites is influenced by the size of the current population more strongly than is the average number of nucleotide differences, while the average number of nucleotide differences is affected by the size of the original population more severely than is the number of segregating sites. The results also indicate that the average number of nucleotide differences is affected by a population bottleneck more strongly than is the number of segregating sites.

scholarly journals DNA Polymorphism in Lycopersicon and Crossing-Over per Physical Length

Genetics ◽  
1998 ◽  
Vol 150 (4) ◽  
pp. 1585-1593 ◽  
Author(s):  
Wolfgang Stephan ◽  
Charles H Langley
Keyword(s):  
Dna Sequence ◽  
Dna Polymorphism ◽  
Sequence Polymorphism ◽  
Breeding Systems ◽  
Crossing Over ◽  
Physical Length ◽  
Interspecific Divergence ◽  
Dna Sequence Polymorphism ◽  
Outcrossing Species ◽  
Genomic Regions

Abstract Surveys in Drosophila have consistently found reduced levels of DNA sequence polymorphism in genomic regions experiencing low crossing-over per physical length, while these same regions exhibit normal amounts of interspecific divergence. Here we show that for 36 loci across the genomes of eight Lycopersicon species, naturally occurring DNA polymorphism (scaled by locus-specific divergence between species) is positively correlated with the density of crossing-over per physical length. Large between-species differences in the amount of DNA sequence polymorphism reflect breeding systems: selfing species show much less within-species polymorphism than outcrossing species. The strongest association of expected heterozygosity with crossing-over is found in species with intermediate levels of average nucleotide diversity. All of these observations appear to be in qualitative agreement with the hitchhiking effects caused by the fixation of advantageous mutations and/or “background selection” against deleterious mutations.

scholarly journals Detecting a Local Signature of Genetic Hitchhiking Along a Recombining Chromosome

Genetics ◽  
2002 ◽  
Vol 160 (2) ◽  
pp. 765-777 ◽  
Author(s):  
Yuseob Kim ◽  
Wolfgang Stephan
Keyword(s):  
Genetic Variation ◽  
Dna Polymorphism ◽  
Nucleotide Diversity ◽  
Sequence Data ◽  
Directional Selection ◽  
Genetic Hitchhiking ◽  
Dna Sequence Data ◽  
Local Reduction ◽  
Polymorphism Data ◽  
Ancestral Recombination Graphs

Abstract The theory of genetic hitchhiking predicts that the level of genetic variation is greatly reduced at the site of strong directional selection and increases as the recombinational distance from the site of selection increases. This characteristic pattern can be used to detect recent directional selection on the basis of DNA polymorphism data. However, the large variance of nucleotide diversity in samples of moderate size imposes difficulties in detecting such patterns. We investigated the patterns of genetic variation along a recombining chromosome by constructing ancestral recombination graphs that are modified to incorporate the effect of genetic hitchhiking. A statistical method is proposed to test the significance of a local reduction of variation and a skew of the frequency spectrum caused by a hitchhiking event. This method also allows us to estimate the strength and the location of directional selection from DNA sequence data.

Optimal use of restriction enzymes in the analysis of human DNA polymorphism

1983 ◽  
Vol 63 (2) ◽  
pp. 162-165 ◽  
Author(s):  
F. Basti�-Sigeac ◽  
G. Lucotte
Keyword(s):  
Dna Polymorphism ◽  
Restriction Enzymes ◽  
Human Dna
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