Reconciling the Human, Organisational, and Technical Factors of is Development

Author(s):  
Robert Moreton ◽  
Myrvin Chester
Author(s):  
SM Dudea ◽  
C Botar-Jid ◽  
D Dumitriu ◽  
A Ciurea ◽  
A Chiorean ◽  
...  

Author(s):  
Shashank Shekhar Mishra ◽  
Chandra Shekhar Sharma ◽  
Hemendra Pratap Singh ◽  
Harshda Pandiya ◽  
Neeraj Kumar

Tuberculosis, one of the most frequent infectious diseases, is caused by a mycobacterium tuberculosis bacteria and it infects several hundred million people each year, results in several million deaths annually. Because there is development of antibiotic resistance, the disease becomes incurable. So, in the absence of effective and potent drug with minimal resistance problems, the mortality rate increases annually. In this computational investigation, we performed In-silico ADME, bioactivity and toxicity parameters calculation of some selected anti-tuberculosis agents. To design a new molecule having good pharmacological profile, this study will provide the lead information.Key Words: Tuberculosis (TB), Bacillus Calmette-Guerin vaccine, TPSA, In Silico toxicity


1998 ◽  
Vol 17 (1) ◽  
pp. 63-68
Author(s):  
Ron Clarke

Although ill-defined, the term “development management” is broadly understood to refer to the management of economic and social development, and the reduction of poverty, at various levels from macro to micro, in lower income countries. “Development management” pre-supposes “development managers”, but this term is even less well defined. Popular perceptions suggest that the concept is less easily applied at the macro level, but more readily at the micro, and also more to someone who is development-minded than someone whose job is to manage or implement development policies and processes, although the two can overlap. This perception – and its implications for management training – is followed through to suggest a profile of a development manager as someone who is forward-thinking, people-oriented, resourceful, flexible in his or her approach to means of achieving objectives, and morally committed.


Buildings ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 270
Author(s):  
Mostafa Babaeian Jelodar ◽  
Feiya Shu

The low-level application of digital tools and information systems in construction implies that many projects cannot meet modern requirements and standard of work of advanced industries. This study adopts a practical and diagnostic approach to identify key attributes and implementation processes of information systems in construction and logistics. To have triangulation of knowledge, a three-step methodology is adopted. Initially an exploratory analysis of previous literature is performed. Secondly a diagnostic analysis of IS applications in construction is achieved by case studies. Finally, expert interviews are performed to examine and consolidate the findings. The study illustrated practical and innovative applications of low-cost digital tools in IS development and created a framework for documentation of these discrete and mostly unshared practices. It is recommended that the construction sector should embrace more advance technologies to minimise human intervention and enhance real-time capabilities. The practicality of how different low-cost and off-the-shelf tools and digital platforms can be combined is discussed and demonstrated. The study provides a clear distinction for practitioners and academics as to what is being practiced in comparison to the dominant theories.


2021 ◽  
Vol 10 ◽  
pp. 216495612198970
Author(s):  
Larry D Gruppen ◽  
Miklos C Fogarasi

The learning environment (LE) provides a context for many educational phenomena, of which wellness and burnout are particularly important. The LE can be thought of as consisting of a psychosocial dimension of personal, social, and organizational factors and a sociomaterial dimension that consists of spatial and technical factors. The interplay between elements of the LE and wellness of the participants is complex and only partially understood, requiring further research. Using this multidimensional model to describe and to plan to deliberately modify the learning environment can foster more rigorous and meaningful research evidence about the interaction of wellness and the LE. This article highlights four key considerations that scholars of wellness should consider when exploring the impact of the LE or designing interventions to modify the environment. These include 1) a thoughtful definition and theoretical conceptualization of the LE, 2) clarity about the study variables that are essential to the study question(s), 3) thoughtful and appropriate measurement of those variables, and 4) a study design that balances quality with feasibility. We provide a practical illustration of how these considerations can be applied in studies exploring the intersection of wellness and the LE.


Author(s):  
Marco-Christopher Rupp ◽  
Philipp W. Winkler ◽  
Patricia M. Lutz ◽  
Markus Irger ◽  
Philipp Forkel ◽  
...  

Abstract Purpose To evaluate the incidence, morphology, and associated complications of medial cortical hinge fractures after lateral closing wedge distal femoral osteotomy (LCW-DFO) for varus malalignment and to identify constitutional and technical factors predisposing for hinge fracture and consecutive complications. Methods Seventy-nine consecutive patients with a mean age of 47 ± 12 years who underwent LCW-DFO for symptomatic varus malalignment at the authors’ institution between 01/2007 and 03/2018 with a minimum of 2-year postoperative time interval were enrolled in this retrospective observational study. Demographic and surgical data were collected. Measurements evaluating the osteotomy cut (length, wedge height, hinge angle) and the location of the hinge (craniocaudal and mediolateral orientation, relation to the adductor tubercle) were conducted on postoperative anterior–posterior knee radiographs and the incidence and morphology of medial cortical hinge fractures was assessed. A risk factor analysis of constitutional and technical factors predisposing for the incidence of a medial cortical hinge fracture and consecutive complications was conducted. Results The incidence of medial cortical hinge fractures was 48%. The most frequent morphological type was an extension fracture type (68%), followed by a proximal (21%) and distal fracture type (11%). An increased length of the osteotomy in mm (53.1 ± 10.9 vs. 57.7 ± 9.6; p = 0.049), an increased height of the excised wedge in mm (6.5 ± 1.9 vs. 7.9 ± 3; p = 0.040) as well as a hinge location in the medial sector of an established sector grid (p = 0.049) were shown to significantly predispose for the incidence of a medial cortical hinge fracture. The incidence of malunion after hinge fracture (14%) was significantly increased after mediolateral dislocation of the medial cortical bone > 2 mm (p < 0.05). Conclusion Medial cortical hinge fractures after LCW-DFO are a common finding. An increased risk of sustaining a hinge fracture has to be expected with increasing osteotomy wedge height and a hinge position close to the medial cortex. Furthermore, dislocation of a medial hinge fracture > 2 mm was associated with malunion and should, therefore, be avoided. Level of evidence Prognostic study; Level IV.


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