Role of Fe(III) in Fe(II)citrate-mediated peroxidation of mitochondrial membrane lipids

1999 ◽  
pp. 163-168
Author(s):  
Roger F. Castilho ◽  
André R. Meinicke ◽  
Anibal E. Vercesi ◽  
Marcelo Hermes-Lima
Keyword(s):  
Mitochondrial Membrane ◽  
Membrane Lipids

scholarly journals Mechanisms Underlying the Essential Role of Mitochondrial Membrane Lipids in Yeast Chronological Aging

2017 ◽  
Vol 2017 ◽  
pp. 1-15 ◽  
Author(s):  
Younes Medkour ◽  
Paméla Dakik ◽  
Mélissa McAuley ◽  
Karamat Mohammad ◽  
Darya Mitrofanova ◽  
...  
Keyword(s):  
Mitochondrial Membrane ◽  
Essential Role ◽  
Membrane Lipids ◽  
Cellular Aging ◽  
Cellular Mechanisms ◽  
Chronological Aging ◽  
Age Related ◽  
Yeast Aging ◽  
Key Aspects

The functional state of mitochondria is vital to cellular and organismal aging in eukaryotes across phyla. Studies in the yeast Saccharomyces cerevisiae have provided evidence that age-related changes in some aspects of mitochondrial functionality can create certain molecular signals. These signals can then define the rate of cellular aging by altering unidirectional and bidirectional communications between mitochondria and other organelles. Several aspects of mitochondrial functionality are known to impact the replicative and/or chronological modes of yeast aging. They include mitochondrial electron transport, membrane potential, reactive oxygen species, and protein synthesis and proteostasis, as well as mitochondrial synthesis of iron-sulfur clusters, amino acids, and NADPH. Our recent findings have revealed that the composition of mitochondrial membrane lipids is one of the key aspects of mitochondrial functionality affecting yeast chronological aging. We demonstrated that exogenously added lithocholic bile acid can delay chronological aging in yeast because it elicits specific changes in mitochondrial membrane lipids. These changes allow mitochondria to operate as signaling platforms that delay yeast chronological aging by orchestrating an institution and maintenance of a distinct cellular pattern. In this review, we discuss molecular and cellular mechanisms underlying the essential role of mitochondrial membrane lipids in yeast chronological aging.

Mitochondrial Membrane Lipids in Life and Death and their Molecular Modulation by Diet: Tuning the Furnace

2014 ◽  
Vol 15 (8) ◽  
pp. 797-810 ◽  
Author(s):  
Joao Monteiro ◽  
Catarina Morais ◽  
Paulo Oliveira ◽  
Amalia Jurado
Keyword(s):  
Mitochondrial Membrane ◽  
Membrane Lipids ◽  
Life And Death ◽  
Molecular Modulation

The Role of Lipids and Membranes in the Pathogenesis of Alzheimer's Disease: A Comprehensive View

2018 ◽  
Vol 15 (13) ◽  
pp. 1191-1212 ◽  
Author(s):  
Botond Penke ◽  
Gábor Paragi ◽  
János Gera ◽  
Róbert Berkecz ◽  
Zsolt Kovács ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Signaling Pathways ◽  
Membrane Lipids ◽  
Specific Protein ◽  
Dietary Factors ◽  
Lipid Signaling ◽  
Special Role ◽  
Aβ Peptides

Lipids participate in Amyloid Precursor Protein (APP) trafficking and processing - important factors in the initiation of Alzheimer’s disease (AD) pathogenesis and influence the formation of neurotoxic β-amyloid (Aβ) peptides. An important risk factor, the presence of ApoE4 protein in AD brain cells binds the lipids to AD. In addition, lipid signaling pathways have a crucial role in the cellular homeostasis and depend on specific protein-lipid interactions. The current review focuses on pathological alterations of membrane lipids (cholesterol, glycerophospholipids, sphingolipids) and lipid metabolism in AD and provides insight in the current understanding of biological membranes, their lipid structures and functions, as well as their role as potential therapeutic targets. Novel methods for studying the membrane structure and lipid composition will be reviewed in a broad sense whereas the use of lipid biomarkers for early diagnosis of AD will be shortly summarized. Interactions of Aβ peptides with the cell membrane and different subcellular organelles are reviewed. Next, the details of the most important lipid signaling pathways, including the role of the plasma membrane as stress sensor and its therapeutic applications are given. 4-hydroxy-2-nonenal may play a special role in the initiation of the pathogenesis of AD and thus the “calpain-cathepsin hypothesis” of AD is highlighted. Finally, the most important lipid dietary factors and their possible use and efficacy in the prevention of AD are discussed.

scholarly journals Role of endosomal membrane lipids and NPC2 in cholesterol transfer and membrane fusion

2010 ◽  
Vol 51 (7) ◽  
pp. 1747-1760 ◽  
Author(s):  
Misbaudeen Abdul-Hammed ◽  
Bernadette Breiden ◽  
Matthew A. Adebayo ◽  
Jonathan O. Babalola ◽  
Günter Schwarzmann ◽  
...  
Keyword(s):  
Membrane Fusion ◽  
Membrane Lipids ◽  
Endosomal Membrane

How do mechanosensitive channels sense membrane tension?

2016 ◽  
Vol 44 (4) ◽  
pp. 1019-1025 ◽  
Author(s):  
Tim Rasmussen
Keyword(s):  
Membrane Lipids ◽  
Osmotic Shock ◽  
Md Simulations ◽  
Fatty Acyl ◽  
Membrane Bilayer ◽  
Cross Sectional ◽  
Conducting Path ◽  
Lipid Chain ◽  
Acyl Chains

Mechanosensitive (MS) channels provide protection against hypo-osmotic shock in bacteria whereas eukaryotic MS channels fulfil a multitude of important functions beside osmoregulation. Interactions with the membrane lipids are responsible for the sensing of mechanical force for most known MS channels. It emerged recently that not only prokaryotic, but also eukaryotic, MS channels are able to directly sense the tension in the membrane bilayer without any additional cofactor. If the membrane is solely viewed as a continuous medium with specific anisotropic physical properties, the sensitivity towards tension changes can be explained as result of the hydrophobic coupling between membrane and transmembrane (TM) regions of the channel. The increased cross-sectional area of the MS channel in the active conformation and elastic deformations of the membrane close to the channel have been described as important factors. However, recent studies suggest that molecular interactions of lipids with the channels could play an important role in mechanosensation. Pockets in between TM helices were identified in the MS channel of small conductance (MscS) and YnaI that are filled with lipids. Less lipids are present in the open state of MscS than the closed according to MD simulations. Thus it was suggested that exclusion of lipid fatty acyl chains from these pockets, as a consequence of increased tension, would trigger gating. Similarly, in the eukaryotic MS channel TRAAK it was found that a lipid chain blocks the conducting path in the closed state. The role of these specific lipid interactions in mechanosensation are highlighted in this review.

Modulation of neuronal mitochondrial membrane potential by the NMDA receptor: role of arachidonic acid

1997 ◽  
Vol 777 (1-2) ◽  
pp. 69-74 ◽  
Author(s):  
Antonio Camins ◽  
Francesc X Sureda ◽  
Cecilia Gabriel ◽  
Mercè Pallàs ◽  
Elena Escubedo ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Membrane Potential ◽  
Nmda Receptor ◽  
Mitochondrial Membrane Potential ◽  
Mitochondrial Membrane

The role of mitochondrial membrane potential in ischemic heart failure

Mitochondrion ◽  
2011 ◽  
Vol 11 (5) ◽  
pp. 700-706 ◽  
Author(s):  
Bernhard Kadenbach ◽  
Rabia Ramzan ◽  
Rainer Moosdorf ◽  
Sebastian Vogt
Keyword(s):  
Heart Failure ◽  
Membrane Potential ◽  
Mitochondrial Membrane Potential ◽  
Mitochondrial Membrane ◽  
Ischemic Heart ◽  
Ischemic Heart Failure

scholarly journals Cholesterol provides nonsacrificial protection of membrane lipids from chemical damage at air–water interface

2018 ◽  
Vol 115 (13) ◽  
pp. 3255-3260 ◽  
Author(s):  
Xinxing Zhang ◽  
Kevin M. Barraza ◽  
J. L. Beauchamp
Keyword(s):  
Lipid Membranes ◽  
Membrane Lipids ◽  
Oh Radicals ◽  
Significant Finding ◽  
Water Interface ◽  
Unsaturated Lipids ◽  
Air Water Interface ◽  
Liquid Ordered ◽  
Ester Linkage

The role of cholesterol in bilayer and monolayer lipid membranes has been of great interest. On the biophysical front, cholesterol significantly increases the order of the lipid packing, lowers the membrane permeability, and maintains membrane fluidity by forming liquid-ordered–phase lipid rafts. However, direct observation of any influence on membrane chemistry related to these cholesterol-induced physical properties has been absent. Here we report that the addition of 30 mol % cholesterol to 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) or 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (POPG) monolayers at the air–water interface greatly reduces the oxidation and ester linkage cleavage chemistries initiated by potent chemicals such as OH radicals and HCl vapor, respectively. These results shed light on the indispensable chemoprotective function of cholesterol in lipid membranes. Another significant finding is that OH oxidation of unsaturated lipids generates Criegee intermediate, which is an important radical involved in many atmospheric processes.

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