Oxyradicals as Signal Transducers

1997 ◽  
pp. 289-319 ◽  
Author(s):  
Roy H. Burdon
Keyword(s):  
Signal Transducers

scholarly journals The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins

Oncogene ◽  
1998 ◽  
Vol 17 (15) ◽  
pp. 1893-1901 ◽  
Author(s):  
Wolf Oehrl ◽  
Christian Kardinal ◽  
Sandra Ruf ◽  
Knut Adermann ◽  
John Groffen ◽  
...  
Keyword(s):  
Protein Kinases ◽  
Germinal Center ◽  
Adapter Proteins ◽  
Related Protein ◽  
Signal Transducers

scholarly journals Angiopoietin-Like Growth Factor Involved in Leptin Signaling in the Hypothalamus

2021 ◽  
Vol 22 (7) ◽  
pp. 3443
Author(s):  
Yunseon Jang ◽  
Jun Young Heo ◽  
Min Joung Lee ◽  
Jiebo Zhu ◽  
Changjun Seo ◽  
...  
Keyword(s):  
Growth Factor ◽  
Brain Regions ◽  
Whole Body ◽  
Signal Transducers ◽  
Leptin Signaling ◽  
Stat3 Phosphorylation ◽  
Hypothalamic Regulation ◽  
Induced Signal ◽  
Body Energy ◽  
Transcription 3

The hypothalamic regulation of appetite governs whole-body energy balance. Satiety is regulated by endocrine factors including leptin, and impaired leptin signaling is associated with obesity. Despite the anorectic effect of leptin through the regulation of the hypothalamic feeding circuit, a distinct downstream mediator of leptin signaling in neuron remains unclear. Angiopoietin-like growth factor (AGF) is a peripheral activator of energy expenditure and antagonizes obesity. However, the regulation of AGF expression in brain and localization to mediate anorectic signaling is unknown. Here, we demonstrated that AGF is expressed in proopiomelanocortin (POMC)-expressing neurons located in the arcuate nucleus (ARC) of the hypothalamus. Unlike other brain regions, hypothalamic AGF expression is stimulated by leptin-induced signal transducers and activators of transcription 3 (STAT3) phosphorylation. In addition, leptin treatment to hypothalamic N1 cells significantly enhanced the promoter activity of AGF. This induction was abolished by the pretreatment of ruxolitinib, a leptin signaling inhibitor. These results indicate that hypothalamic AGF expression is induced by leptin and colocalized to POMC neurons.

scholarly journals Silicon Nanocrystals as Signal Transducers in Ionophore-Based Fluorescent Nanosensors

2020 ◽  
pp. 129350
Author(s):  
Mark S. Ferris ◽  
Ashley P. Chesney ◽  
Bradley J. Ryan ◽  
Utkarsh Ramesh ◽  
Matthew G. Panthani ◽  
...  
Keyword(s):  
Silicon Nanocrystals ◽  
Signal Transducers

Involvement of signal transducers and activators of transcription in trophoblast differentiation

Placenta ◽  
2021 ◽  
Vol 105 ◽  
pp. 94-103
Author(s):  
Chao Chen ◽  
Xiaomin Kang ◽  
Congcong Li ◽  
Feng Guo ◽  
Qiaohong Wang ◽  
...  
Keyword(s):  
Trophoblast Differentiation ◽  
Signal Transducers ◽  
Signal Transducers And Activators

scholarly journals Investigation of JAK2V617F Mutation Prevalence in Patients with Beta Thalassemia Major

2019 ◽  
Author(s):  
Zari Tahannejad Asadi ◽  
Reza Yarahmadi ◽  
Najmaldin Saki ◽  
Mohammad Taha Jalali ◽  
Ali Amin Asnafi ◽  
...  
Keyword(s):  
Genetic Disorder ◽  
Thalassemia Major ◽  
Janus Kinase ◽  
Jak2v617f Mutation ◽  
Beta Thalassemia ◽  
Common Mutation ◽  
Signal Transducers ◽  
Significant Difference ◽  
Polymerase Chain ◽  
Low Prevalence

AbstractBackgroundBeta (β)–thalassemia major is a genetic disorder with anemia and an increased level of erythropoietin by Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway. JAK plays an important role in cell signaling, and the common mutation in the JAK2 gene in myeloid disorders is called JAK2V617F.MethodsA total of 75 patients with beta (β)-thalassemia major patients, including 34 males (45%) and 41 females (55%), were enrolled in this study. The presence of the JAK2V617F mutation was assessed using the amplification-refractory mutation–polymerase chain reaction (ARMS-PCR) technique.ResultsAmong the 75 patients, 14 patients (19%) tested positive and 61 patients (81%) tested negative for JAK2V617F mutation. We observed no statistically significant difference in sex, age, genotype, and JAK2V617F mutation among patients (P> .05). However, a significant difference between blood-transfusion frequency and JAK2V617F mutation was observed (P <.05).ConclusionDue to the low prevalence of JAK2V617F mutation in thalassemia, using a larger population of the patients to investigate this mutation in ineffective erythropoiesis can be useful.

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