Metabolic Changes in Human Placental Tissue in Diabetes Mellitus

1984 ◽  
pp. 209-221
Author(s):  
Yoram Z. Diamant ◽  
Rita Kissilevitz
Keyword(s):  
Diabetes Mellitus ◽  
Placental Tissue ◽  
Metabolic Changes ◽  
Human Placental Tissue

A Preliminary Study on Human Placental Tissue Impaired by Gestational Diabetes: A Comparison of Gel-Based versus Gel-Free Proteomics Approaches

2016 ◽  
Vol 22 (2) ◽  
pp. 71-82 ◽  
Author(s):  
Marco Roverso ◽  
Maura Brioschi ◽  
Cristina Banfi ◽  
Silvia Visentin ◽  
Silvia Burlina ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Placental Tissue ◽  
Human Placental Tissue ◽  
Preliminary Study

scholarly journals Seasonally Variant Gene Expression in Full-Term Human Placenta

2020 ◽  
Author(s):  
Danielle A. Clarkson-Townsend ◽  
Elizabeth Kennedy ◽  
Todd M. Everson ◽  
Maya A. Deyssenroth ◽  
Amber A. Burt ◽  
...  
Keyword(s):  
Health Outcomes ◽  
Placental Tissue ◽  
Later Life ◽  
Full Term ◽  
Season Of Birth ◽  
Rhythmic Expression ◽  
Health And Development ◽  
Human Placental Tissue ◽  
Variant Genes ◽  
Ribosomal Activity

ABSTRACTSeasonal exposures influence human health and development. The placenta, as a mediator of the maternal and fetal systems and a regulator of development, is an ideal tissue to understand the biological pathways underlying relationships between season of birth and later life health outcomes. Here, we conducted a transcriptome-wide association study of season of birth in full-term human placental tissue to evaluate whether the placenta may be influenced by seasonal cues. Of the analyzed transcripts, 583 displayed differential expression between summer and winter births (FDR q<0.05); among these, BHLHE40, MIR210HG, and HILPDA had increased expression among winter births (Bonferroni p<0.05). Enrichment analyses of the seasonally variant genes between summer and winter births indicated over-representation of transcription factors HIF1A, VDR, and CLOCK, among others, and of GO term pathways related to ribosomal activity and infection. Additionally, a cosinor analysis found rhythmic expression for approximately 11.9% of all 17,664 analyzed placental transcripts. These results suggest that the placenta responds to seasonal cues and add to the growing body of evidence that the placenta acts as a peripheral clock, which may provide a molecular explanation for the extensive associations between season of birth and health outcomes.

The specific 3H-ouabain binding to Na+/K+-ATPase of the human placental tissue is inhibited by newborn plasma extracts

Steroids ◽  
1988 ◽  
Vol 52 (4) ◽  
pp. 363-364
Author(s):  
Anna Paci ◽  
Silvana Balzan ◽  
Franca Cocci ◽  
Hans Peter Niedermeyer ◽  
Aldo Clerico
Keyword(s):  
Placental Tissue ◽  
Ouabain Binding ◽  
Human Placental Tissue

Elevated pro-angiogenic phenotype in feto-placental tissue from gestational diabetes mellitus

Placenta ◽  
2015 ◽  
Vol 36 (4) ◽  
pp. 485
Author(s):  
F. Troncoso ◽  
J. Acurio ◽  
K. Herlitz ◽  
F. Ruiz ◽  
P. Bertoglia ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Placental Tissue

From naive iPS cells toward human placental tissue via trophectoderm

Placenta ◽  
2021 ◽  
Vol 114 ◽  
pp. 151-152
Author(s):  
Shingo Io ◽  
Eiji Kondoh ◽  
Yasuhiro Takashima ◽  
Masaki Mandai
Keyword(s):  
Placental Tissue ◽  
Ips Cells ◽  
Human Placental Tissue

Addressing the Unintentional Consequences of Cancer Therapy With Novel Integrative Therapeutics

2018 ◽  
pp. 822-828 ◽  
Author(s):  
Ting Bao ◽  
Luke J. Peppone ◽  
Patricia Robinson
Keyword(s):  
Diabetes Mellitus ◽  
United States ◽  
Bone Resorption ◽  
Cancer Care ◽  
The United States ◽  
Metabolic Changes ◽  
Vasomotor Symptoms ◽  
Negative Effects ◽  
Alternative Strategies ◽  
Metabolic Alterations

There are 15.5 million cancer survivors in the United States because of, in part, improvements in therapy. As a result, there will be an increased burden of long- and late-term complications of cancer care, such as metabolic alterations. These metabolic changes will include alterations in bone resorption, obesity, hypercholesterolemia, and diabetes mellitus. The majority of cancer treatment–related toxicities have focused on endocrine therapy; however, chemotherapy and supportive medications, such as steroids, contribute to the development of these disorders. Because of the chronicity of these metabolic changes and their impact on morbidity, cancer risk, and outcomes as well other negative effects, including musculoskeletal pain and vasomotor symptoms, alternative strategies must be developed. These strategies should include nonpharmacologic approaches. Here, we summarize metabolic changes secondary to cancer care and integrative approaches to help alleviate therapy-associated toxicities.

scholarly journals Course of placental 11beta-hydroxysteroid dehydrogenase type 2 and 15-hydroxyprostaglandin dehydrogenase mRNA expression during human gestation

2001 ◽  
pp. 187-192 ◽  
Author(s):  
E Schoof ◽  
M Girstl ◽  
W Frobenius ◽  
M Kirschbaum ◽  
R Repp ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mrna Expression ◽  
Placental Tissue ◽  
Hydroxysteroid Dehydrogenase ◽  
Normal Pregnancy ◽  
Premature Babies ◽  
Gene Level ◽  
Human Placental Tissue ◽  
Human Placental Cells

BACKGROUND: During human pregnancy, 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) plays an important role in protecting the fetus from high maternal glucocorticoid concentrations by converting cortisol to inactive cortisone. Furthermore, 11beta-HSD2 is indirectly involved in the regulation of the prostaglandin inactivating enzyme 15-hydroxyprostaglandin dehydrogenase (PGDH), because cortisol reduces the gene expression and enzyme activity of PGDH in human placental cells. OBJECTIVE: To examine developmental changes in placental 11beta-HSD2 and PGDH gene expression during the 2nd and 3rd trimesters of human pregnancies. METHODS: In placental tissue taken from 20 healthy women with normal pregnancy and 20 placentas of 17 mothers giving birth to premature babies, 11beta-HSD2 and PGDH mRNA expression was determined using quantitative real-time PCR. RESULTS: Placental mRNA expression of 11beta-HSD2 and PGDH increased significantly with gestational age (r=0.55, P=0.0002 and r=0.42, P=0.007). In addition, there was a significant correlation between the two enzymes (r=0.58, P<0.0001). CONCLUSIONS: In the course of pregnancy there is an increase in 11beta-HSD2 and PGDH mRNA expression in human placental tissue. This adaptation of 11beta-HSD2 prevents increasing maternal cortisol concentrations from transplacental passage and is exerted at the gene level. 11beta-HSD2 up-regulation may also lead to an increase in PGDH mRNA concentrations that, until term, possibly delays myometrial contractions induced by prostaglandins.

The relationship between human β-defensin 3 (hBD3) expression and mean histamine concentration in human placental tissue

2008 ◽  
Vol 57 (S1) ◽  
pp. 69-70 ◽  
Author(s):  
D. Szukiewicz ◽  
J. Klimkiewicz ◽  
M. Pyzlak ◽  
A. Szukiewicz ◽  
D. Maslinska
Keyword(s):  
Placental Tissue ◽  
Histamine Concentration ◽  
Human Placental Tissue ◽  
The Relationship
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