A Polymorphism in the Rat Liver Mitochondrial ALDH2 Gene is Associated with Alcohol Drinking Behavior

Author(s):  
L. Carr ◽  
B. Mellencamp ◽  
D. Crabb ◽  
L. Lumeng ◽  
T.-K. Li
Author(s):  
Hitoshi Ishikawa ◽  
Hidetaka Yamamoto ◽  
Ying Tian ◽  
Mitsuo Kawano ◽  
Toru Yamauchi ◽  
...  

2007 ◽  
Vol 27 (13) ◽  
pp. 3593-3602 ◽  
Author(s):  
J. Wang ◽  
S. Carnicella ◽  
K. Phamluong ◽  
J. Jeanblanc ◽  
J. A. Ronesi ◽  
...  

2020 ◽  
Vol 26 (20) ◽  
pp. 2309-2315 ◽  
Author(s):  
Julianna Brutman ◽  
Jon F. Davis ◽  
Sunil Sirohi

A complex interplay of peripheral and central signaling mechanisms within the body of an organism maintains energy homeostasis. In addition, energy/food intake is modified by various external factors (e.g., palatability, food availability, social and environmental triggers). Highly palatable foods can provoke maladaptive feeding behavior, which in turn disrupts normal homeostatic regulation resulting in numerous health consequences. Furthermore, neuroendocrine peptides, traditionally considered to regulate appetite and energy homeostasis, also control the intake and reinforcing properties of alcohol and drugs of abuse. Therefore, dysregulated eating as a result of a hedonic/binge-like intake of hyper-palatable food may impact alcohol drinking behavior. Relevant in this case is the fact that eating disorders are highly comorbid with several neuropsychiatric conditions, including alcohol use disorder. The present review is intended to summarize the neurobiological and functional consequences of hedonic feeding on alcohol intake.


Author(s):  
E. A. Budygin

Despite many years of work on dopaminergic mechanisms of alcohol addiction, much of this evidence remains mostly correlative in nature. Fortunately, the latest technological advances have provided the opportunity to explore the causal role of neurochemical changes within brain regions involved in addictive behaviors. In this work using optogenetics, we have attempted to answer the question of how dopamine release dynamics control the motivational component of alcohol drinking behavior.


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