Effects of ALDH2 gene polymorphisms and alcohol-drinking behavior on micronuclei frequency in non-smokers

2003 ◽  
Vol 541 (1-2) ◽  
pp. 71-80 ◽  
Author(s):  
Hitoshi Ishikawa ◽  
Hidetaka Yamamoto ◽  
Ying Tian ◽  
Mitsuo Kawano ◽  
Toru Yamauchi ◽  
...  
Keyword(s):  
Alcohol Drinking ◽  
Gene Polymorphisms ◽  
Drinking Behavior ◽  
Aldh2 Gene

scholarly journals The Correlation of Cyp2e1 Genetic Polymorphism on Alcohol Drinking Habits in Papuan Ethnicity

2021 ◽  
Vol 21 (2) ◽  
pp. 117-123
Author(s):  
Mardhatillah Marsa ◽  
Yudha Nurhantari ◽  
Suhartini Suhartini ◽  
Tri Ratnaningsih
Keyword(s):  
Endoplasmic Reticulum ◽  
Genetic Polymorphism ◽  
Alcohol Abuse ◽  
Alcohol Drinking ◽  
Gene Polymorphisms ◽  
Genetic Factors ◽  
Drinking Behavior ◽  
Alcohol Metabolism ◽  
Drinking Habits ◽  
The Subject

Alcohol abuse is associated with genetic factors and is influenced by certain races and ethnicities. CYP2E1, which works on the endoplasmic reticulum, produces an enzyme that plays a significant role in alcohol metabolism. In relation to it, this study aims to identify the polymorphisms of CYP2E1*5B and CYP2E1*6 genes in alcohol drinkers of Papuan Ethnics. A total of 39 Papuans were analyzed for alcohol drinking habits. Alcohol drinkers were found to be 29 people (74.4%), and 10 people (25.6%) were non-drinkers. The drinkers mainly were late teenagers (89,7%) and males (69,2%). The CYP2E1*5B genotypes were c1/c1 as 94.9% and c1/c2 as 5.1%. Meanwhile, the CYP2E1*6 T/T genotypes were 56.4%, and T/A genotypes were 43.6%. The odd ratio for CYP2E1*5B were 18,5 and 7,7 for CYP2E1*6. p0,05 for CYP2E1*5B and CYP2E1*6 gene polymorphisms for alcohol drinking behavior in the form of frequency, duration, type, and volume of alcohol consumed. Furthermore, c1/c1 and c1/c2 genotype polymorphisms were in CYP2E1*5B; T/T and T/A genotypes were in CYP2E1*6 of Papuan ethnic at Yogyakarta. In conclusion, genotype c1/c1 had 18,5 times of the possibility of being alcoholic drinkers, and genotype T/T had 7,7 times of the possibility of being alcoholic drinkers in Papuan ethnic. It indicated that the type of genotype statistically did not significantly affect alcohol drinking behavior on the subject.

scholarly journals Ethanol Induces Long-Term Facilitation of NR2B-NMDA Receptor Activity in the Dorsal Striatum: Implications for Alcohol Drinking Behavior

2007 ◽  
Vol 27 (13) ◽  
pp. 3593-3602 ◽  
Author(s):  
J. Wang ◽  
S. Carnicella ◽  
K. Phamluong ◽  
J. Jeanblanc ◽  
J. A. Ronesi ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Alcohol Drinking ◽  
Drinking Behavior ◽  
Dorsal Striatum ◽  
Receptor Activity ◽  
Long Term Facilitation

scholarly journals Behavioral and Neurobiological Consequences of Hedonic Feeding on Alcohol Drinking

2020 ◽  
Vol 26 (20) ◽  
pp. 2309-2315 ◽  
Author(s):  
Julianna Brutman ◽  
Jon F. Davis ◽  
Sunil Sirohi
Keyword(s):  
Alcohol Drinking ◽  
Alcohol Intake ◽  
Energy Homeostasis ◽  
Drugs Of Abuse ◽  
Drinking Behavior ◽  
The Body ◽  
Alcohol And Drugs ◽  
Signaling Mechanisms ◽  
Functional Consequences ◽  
Neuropsychiatric Conditions

A complex interplay of peripheral and central signaling mechanisms within the body of an organism maintains energy homeostasis. In addition, energy/food intake is modified by various external factors (e.g., palatability, food availability, social and environmental triggers). Highly palatable foods can provoke maladaptive feeding behavior, which in turn disrupts normal homeostatic regulation resulting in numerous health consequences. Furthermore, neuroendocrine peptides, traditionally considered to regulate appetite and energy homeostasis, also control the intake and reinforcing properties of alcohol and drugs of abuse. Therefore, dysregulated eating as a result of a hedonic/binge-like intake of hyper-palatable food may impact alcohol drinking behavior. Relevant in this case is the fact that eating disorders are highly comorbid with several neuropsychiatric conditions, including alcohol use disorder. The present review is intended to summarize the neurobiological and functional consequences of hedonic feeding on alcohol intake.

scholarly journals Optogenetic approaches for the analysis of the role of dopaminergic neurotransmission in the development of alcohol dependence: from correlations to mechanisms

2019 ◽  
pp. 39-40
Author(s):  
E. A. Budygin
Keyword(s):  
Alcohol Drinking ◽  
Dopamine Release ◽  
Drinking Behavior ◽  
Brain Regions ◽  
Alcohol Addiction ◽  
Addictive Behaviors ◽  
Technological Advances ◽  
Dopaminergic Mechanisms ◽  
Neurochemical Changes

Despite many years of work on dopaminergic mechanisms of alcohol addiction, much of this evidence remains mostly correlative in nature. Fortunately, the latest technological advances have provided the opportunity to explore the causal role of neurochemical changes within brain regions involved in addictive behaviors. In this work using optogenetics, we have attempted to answer the question of how dopamine release dynamics control the motivational component of alcohol drinking behavior.

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