Design of Membrane-Based Bioartificial Organs

1996 ◽  
pp. 223-236 ◽  
Author(s):  
Frank T. Gentile ◽  
Edward J. Doherty ◽  
Rebecca H. Li ◽  
David H. Rein ◽  
Dwaine F. Emerich
Keyword(s):  
Bioartificial Organs

SiO2 Entrapment of Animal Cells for Hybrid Bioartificial Organs

2000 ◽  
Vol 628 ◽  
Author(s):  
Giovanni Carturan ◽  
Renzo Dal Monte ◽  
Maurizio Muraca
Keyword(s):  
Gas Phase ◽  
Mechanical Stability ◽  
Porous Silica ◽  
Collagen Matrix ◽  
Homogeneous Layer ◽  
Animal Cells ◽  
Bioartificial Organs ◽  
Liver And Pancreas ◽  
Encapsulation Method ◽  
Metabolic Activities

ABSTRACTSi-alkoxides in gas phase are reactive towards the surface of animal cells, depositing a homogeneous layer of porous silica. This encapsulation method preserves cell viability and does not alter the hindrance of the biological load.In the prospective use for the design of a hybrid bioartificial liver, hepatocytes in a collagen matrix can be entrapped by the siliceous deposit which provides definite mechanical stability to the collagen matrix and molecular cutoff vs. high molecular weight proteins, including immunoglobulins. The functionality of the encapsulated cell load is maintained for the expressions of typical liver and pancreas metabolic activities.

scholarly journals Advancements in Assessments of Bio-Tissue Engineering and Viable Cell Delivery Matrices Using Bile Acid-Based Pharmacological Biotechnologies

Nanomaterials ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1861
Author(s):  
Armin Mooranian ◽  
Melissa Jones ◽  
Corina Mihaela Ionescu ◽  
Daniel Walker ◽  
Susbin Raj Wagle ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Viable Cell ◽  
Cell Delivery ◽  
Artificial Organ ◽  
Bioartificial Pancreas ◽  
Advantages And Disadvantages ◽  
Wide Range ◽  
Bioartificial Organs ◽  
Significant Interest ◽  
Modern Technologies

The utilisation of bioartificial organs is of significant interest to many due to their versatility in treating a wide range of disorders. Microencapsulation has a potentially significant role in such organs. In order to utilise microcapsules, accurate characterisation and analysis is required to assess their properties and suitability. Bioartificial organs or transplantable microdevices must also account for immunogenic considerations, which will be discussed in detail. One of the most characterized cases is the investigation into a bioartificial pancreas, including using microencapsulation of islets or other cells, and will be the focus subject of this review. Overall, this review will discuss the traditional and modern technologies which are necessary for the characterisation of properties for transplantable microdevices or organs, summarizing analysis of the microcapsule itself, cells and finally a working organ. Furthermore, immunogenic considerations of such organs are another important aspect which is addressed within this review. The various techniques, methodologies, advantages, and disadvantages will all be discussed. Hence, the purpose of this review is providing an updated examination of all processes for the analysis of a working, biocompatible artificial organ.

Ethics of First-in-Human Transplantation Trials of Bioartificial Organs

2021 ◽  
Vol 66 (Special Issue) ◽  
pp. 62-63
Author(s):  
Dide de Jongh ◽  
◽  
Eline Bunnik ◽  
Emma Massey ◽  
◽  
...  
Keyword(s):  
Gene Therapy ◽  
Clinical Trials ◽  
Regenerative Medicine ◽  
Ethical Issues ◽  
Artificial Organs ◽  
Diabetic Patients ◽  
Bioartificial Organs ◽  
Deceased Donors ◽  
Cell And Gene Therapy

"The most effective treatment for type 1 diabetes is transplantation of either a whole pancreas from a deceased donor or islet cells derived from multiple deceased donors. However, transplantation has several limitations, including shortage of post-mortem donors and the need for post-transplant patients to use life-long immunosuppressive medication. In the last decade, the field of regenerative medicine has combined engineering and biological technologies in the attempt to regenerate organs. The European VANGUARD project aims to develop immune-protected bioartificial pancreases for transplantation into non-immunosuppressed type 1 diabetic patients. This project is creating a ‘combination product’ using cells and tissue from a variety of sources, including placentas and deceased donors. The clinical development of this complex product raises ethical questions for first-in-human (FIH) clinical trials. Under what conditions can bio-artificial organs safely are transplanted in humans for the first time? How can patients be selected, recruited and informed responsibly? In this presentation, we investigate the ethical conditions for clinical trials of bio-engineered organs, focusing inter alia on study design, subject selection, risk-benefit assessment, and informed consent. We present the results of a review of the literature on the ethics of clinical trials in regenerative medicine, cell and gene therapy and transplantation, and specify existing ethical guidance in the context of FIH transplantation trials of bioartificial organs. We conclude that this new and innovative area at the intersection of regenerative medicine, cell and gene therapy and transplantation requires adequate consideration of the ethical issues in order to guide responsible research and clinical implementation. "

Membranes: Bioartificial Organs and Tissue Engineering

2015 ◽  
pp. 4487-4515
Author(s):  
Thomas Groth ◽  
Xiao-Jun Huang ◽  
Zhi-Kang Xu
Keyword(s):  
Tissue Engineering ◽  
Bioartificial Organs

New Technologies for Bioartificial Organs

1998 ◽  
Vol 22 (1) ◽  
pp. 68-74 ◽  
Author(s):  
Wang
Keyword(s):  
New Technologies ◽  
Bioartificial Organs

Dentistry in the 21st Century: A Look into the Future

2009 ◽  
Vol 3 (1) ◽  
pp. 9-14
Author(s):  
Gaurav Vasudeva ◽  
Pawah Salil
Keyword(s):  
Tissue Engineering ◽  
Office Visit ◽  
Considerable Effect ◽  
Nanometer Scale ◽  
Restorative Dentistry ◽  
Exciting Field ◽  
Bioartificial Organs ◽  
Mineralized Tissues ◽  
Oral Wound Healing ◽  
Oral Analgesia

ABSTRACT Modern dentistry and research will make possible the maintenance of comprehensive oral health by involving the use of nanomaterials, biotechnology including tissue engineering and, ultimately, dental nanorobotics (nanomedicine). Within 10 to 20 years, these devices will allow precisely controlled oral analgesia, dentition replacement therapy using biologically autologous whole replacement teeth manufactured during a single office visit, and rapid nanometer-scale precision restorative dentistry. Tissue engineering is a novel and highly exciting field of research that aims to repair damaged tissues as well as create replacement (bioartificial) organs. A general review of the principles underlying key tissue engineering strategies are described. PRACTICE IMPLICATIONS Tissue engineering will have a considerable effect on dental practice during the next 25 years. The greatest effects will likely be related to the repair and replacement of mineralized tissues, the promotion of oral wound healing and the use of gene transfer adjunctively

Microencapsulation: A review of polymers and Technologies with a focus on bioartificial organs

Polimery ◽  
1998 ◽  
Vol 43 (09) ◽  
pp. 530-539 ◽  
Author(s):  
ANDREAS RENKEN ◽  
DAVID HUNKELER
Keyword(s):  
Bioartificial Organs

On the road to bioartificial organs

2014 ◽  
Vol 466 (10) ◽  
pp. 1847-1857 ◽  
Author(s):  
X. Ren ◽  
H. C. Ott
Keyword(s):  
The Road ◽  
Bioartificial Organs ◽  
On The Road
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