The First Formal Test of Significance

2001 ◽  
pp. 7-17
Author(s):  
H. A. David ◽  
A. W. F. Edwards
Keyword(s):  
Test Of Significance ◽  
Formal Test

scholarly journals A Scan for Linkage Disequilibrium Across the Human Genome

Genetics ◽  
1999 ◽  
Vol 152 (4) ◽  
pp. 1711-1722 ◽  
Author(s):  
Gavin A Huttley ◽  
Michael W Smith ◽  
Mary Carrington ◽  
Stephen J O’Brien
Keyword(s):  
Linkage Disequilibrium ◽  
Human Genome ◽  
Pedigree Analysis ◽  
Exact Test ◽  
Genomic Scale ◽  
Genomic Regions ◽  
Formal Test ◽  
Scale Data ◽  
Short Tandem ◽  
Tandem Repeat Polymorphism

Abstract Linkage disequilibrium (LD), the tendency for alleles of linked loci to co-occur nonrandomly on chromosomal haplotypes, is an increasingly useful phenomenon for (1) revealing historic perturbation of populations including founder effects, admixture, or incomplete selective sweeps; (2) estimating elapsed time since such events based on time-dependent decay of LD; and (3) disease and phenotype mapping, particularly for traits not amenable to traditional pedigree analysis. Because few descriptions of LD for most regions of the human genome exist, we searched the human genome for the amount and extent of LD among 5048 autosomal short tandem repeat polymorphism (STRP) loci ascertained as specific haplotypes in the European CEPH mapping families. Evidence is presented indicating that ∼4% of STRP loci separated by <4.0 cM are in LD. The fraction of locus pairs within these intervals that display small Fisher’s exact test (FET) probabilities is directly proportional to the inverse of recombination distance between them (1/cM). The distribution of LD is nonuniform on a chromosomal scale and in a marker density-independent fashion, with chromosomes 2, 15, and 18 being significantly different from the genome average. Furthermore, a stepwise (locus-by-locus) 5-cM sliding-window analysis across 22 autosomes revealed nine genomic regions (2.2-6.4 cM), where the frequency of small FET probabilities among loci was greater than or equal to that presented by the HLA on chromosome 6, a region known to have extensive LD. Although the spatial heterogeneity of LD we detect in Europeans is consistent with the operation of natural selection, absence of a formal test for such genomic scale data prevents eliminating neutral processes as the evolutionary origin of the LD.

IQ Constancy in Disadvantaged Negro Children

1971 ◽  
Vol 29 (1) ◽  
pp. 319-326 ◽  
Author(s):  
Norman A. Milgram
Keyword(s):  
Sex Differences ◽  
Multiple Regression ◽  
Test Performance ◽  
Test Taking ◽  
Comparison Test ◽  
Initial Comparison ◽  
Age Trends ◽  
Iq Scores ◽  
Formal Test

A longitudinal followup of 59 disadvantaged Negro children from age 3 to 8 indicated that: (1) their mean Binet IQ was relatively stable, while their Peabody IQ rose appreciably; (2) the magnitude of the correlation between earlier and later IQ scores was a function of the interval between test-retest and the age of the child on the initial comparison test; (3) ratings on test-taking behavior yielded significant sex differences and age trends; (4) ratings specific to formal test performance were significantly correlated with IQ scores of tests taken concurrent to the ratings and of tests taken one or more years later; (5) these ratings did not, however, enhance in multiple regression the correlation which obtained for predictor and criterion IQ scores alone. Findings were discussed in relation to other studies.

scholarly journals FACTORS INFLUENCING THE PERFORMANCE OF TRAWL OPERATION IN THE WATERS AREA OF TARAKAN

2018 ◽  
Vol 23 (2) ◽  
pp. 79
Author(s):  
Asep Priatna ◽  
Suprapto Suprapto
Keyword(s):  
Principal Component ◽  
Bottom Trawl ◽  
Fish Density ◽  
Trawl Survey ◽  
Door Opening ◽  
Test Of Significance ◽  
Towing Speed ◽  
Bottom Depth ◽  
Catch Composition

Any fish on swept area of bottom trawl could not be caught due to some technical factors during towing. However, it could be estimated by integrated of bottom trawl and acoustic survey. This paper describes the determination of some factors that affect the performance of trawl net during the bottom trawl survey in the waters of Tarakan. Surveys were carried out in May, August, and November 2012. A total of 57 stations of simultaneously acoustic-trawl were completed. Data collected from each station include catch composition, and variables of trawling operation (i.e. bottom depth, warp length, trawl door opening, towing speed, towing duration, and acoustic fish density). Principal component analysis was applied to identify variables might impact of trawling performance (i.e. fish density at the waters area, towing speed, towing duration, warp length, horizontal opening of trawl door, density of non-demersal at cod end, and bottom depth). Both towing speed and towing duration were not major component for trawl operation. According to test of significance for four variables (i.e. bottom depth, warp length, horizontal opening, biota non-demersal at cod end) which affected to fish density at waters area, that both of variable (i.e. warp length and bottom depth) were significant as the principal components for the performance of bottom trawl. 

scholarly journals Socio-economic Determinants of Current use of Contraception in a Rural Area of J&K

JMS SKIMS ◽  
2010 ◽  
Vol 13 (1) ◽  
pp. 30-32
Author(s):  
Amrita Kotwal ◽  
Bhupinder Singh ◽  
Singh Singh ◽  
Ganai A M
Keyword(s):  
Contraceptive Use ◽  
Multiple Logistic Regression Analysis ◽  
Economic Factors ◽  
Lower Income ◽  
Interview Schedule ◽  
Economic Determinants ◽  
Analysis Technique ◽  
Unskilled Workers ◽  
Test Of Significance ◽  
Socio Economic Factors

Objective: To identify the socio-economic factors which determine contraceptive use among current users of contraception. Method:Cross-sectional design. Interview schedule of entire eligible couple population of 19 Angwanwari Centres of Block R.S.Pura, Jammu by House to House Survey. Analysis: Besides test of significance, unadjusted Odd's Ratio, adjusted Odd's Ratio were used using Multiple Logistic Regression Analysis technique by SPSS-WIN Version 7.5 Software. Results: Contraceptive use increased with age of women and number of conceptions. Compared to illiterate women, formally educated women were 2.2 times more likely to use contraception. Also, lower income, wives of unskilled workers and Scheduled Caste (SC) woman were more likely to be current users of contraception. Husband's age & literacy, religion and type of family did not show significant relationship with current contraceptive use. J Med Sci.2010; 13(1): 30-32

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