Lipid Metabolism In The Squid Nervous System

1990 ◽  
pp. 323-368 ◽  
Author(s):  
Robert M. Gould ◽  
Mario Alberghina
Keyword(s):  
Nervous System ◽  
Lipid Metabolism

scholarly journals The Role of Lipids, Lipid Metabolism and Ectopic Lipid Accumulation in Axon Growth, Regeneration and Repair after CNS Injury and Disease

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1078
Author(s):  
Debasish Roy ◽  
Andrea Tedeschi
Keyword(s):  
Nervous System ◽  
Lipid Metabolism ◽  
Lipid Accumulation ◽  
Axon Regeneration ◽  
Axon Growth ◽  
The Body ◽  
Cns Repair ◽  
Cord Injury ◽  
Cns Trauma

Axons in the adult mammalian nervous system can extend over formidable distances, up to one meter or more in humans. During development, axonal and dendritic growth requires continuous addition of new membrane. Of the three major kinds of membrane lipids, phospholipids are the most abundant in all cell membranes, including neurons. Not only immature axons, but also severed axons in the adult require large amounts of lipids for axon regeneration to occur. Lipids also serve as energy storage, signaling molecules and they contribute to tissue physiology, as demonstrated by a variety of metabolic disorders in which harmful amounts of lipids accumulate in various tissues through the body. Detrimental changes in lipid metabolism and excess accumulation of lipids contribute to a lack of axon regeneration, poor neurological outcome and complications after a variety of central nervous system (CNS) trauma including brain and spinal cord injury. Recent evidence indicates that rewiring lipid metabolism can be manipulated for therapeutic gain, as it favors conditions for axon regeneration and CNS repair. Here, we review the role of lipids, lipid metabolism and ectopic lipid accumulation in axon growth, regeneration and CNS repair. In addition, we outline molecular and pharmacological strategies to fine-tune lipid composition and energy metabolism in neurons and non-neuronal cells that can be exploited to improve neurological recovery after CNS trauma and disease.

The effect of central nervous system(CNS) lesion on lipid metabolism in rat liver

1985 ◽  
Vol 3 ◽  
pp. S23
Author(s):  
Shunichi Murano ◽  
Kohji Shirai ◽  
Yasushi Saito ◽  
Sho Yoshida
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Lipid Metabolism ◽  
Rat Liver

The autonomic nervous system regulates postprandial hepatic lipid metabolism

2013 ◽  
Vol 304 (10) ◽  
pp. E1089-E1096 ◽  
Author(s):  
Eveline Bruinstroop ◽  
Susanne E. la Fleur ◽  
Mariette T. Ackermans ◽  
Ewout Foppen ◽  
Joke Wortel ◽  
...  
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Lipid Metabolism ◽  
Metabolic Regulation ◽  
Sympathetic Innervation ◽  
Plasma Triglyceride ◽  
Fine Tuning ◽  
Autonomic Nervous ◽  
Glucose And Lipid Metabolism ◽  
Postprandial Triglyceride

The liver is a key organ in controlling glucose and lipid metabolism during feeding and fasting. In addition to hormones and nutrients, inputs from the autonomic nervous system are also involved in fine-tuning hepatic metabolic regulation. Previously, we have shown in rats that during fasting an intact sympathetic innervation of the liver is essential to maintain the secretion of triglycerides by the liver. In the current study, we hypothesized that in the postprandial condition the parasympathetic input to the liver inhibits hepatic VLDL-TG secretion. To test our hypothesis, we determined the effect of selective surgical hepatic denervations on triglyceride metabolism after a meal in male Wistar rats. We report that postprandial plasma triglyceride concentrations were significantly elevated in parasympathetically denervated rats compared with control rats ( P = 0.008), and VLDL-TG production tended to be increased ( P = 0.066). Sympathetically denervated rats also showed a small rise in postprandial triglyceride concentrations ( P = 0.045). On the other hand, in rats fed on a six-meals-a-day schedule for several weeks, a parasympathetic denervation resulted in >70% higher plasma triglycerides during the day ( P = 0.001), whereas a sympathetic denervation had no effect. Our results show that abolishing the parasympathetic input to the liver results in increased plasma triglyceride levels during postprandial conditions.

Lipid metabolism in differentiating central nervous system in chick

1967 ◽  
Vol 159 (2) ◽  
pp. 267-272 ◽  
Author(s):  
J. Medda ◽  
A. Bose
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Lipid Metabolism

scholarly journals SOME ASPECTS OF THE PATHOGENESIS OF ISCHEMIC-HYPOXIC LESIONS OF THE CENTRAL NERVOUS SYSTEM IN NEWBORNS

2015 ◽  
Vol 4 (2) ◽  
pp. 112-115
Author(s):  
Lyudmila Viktorovna Ledyaikina ◽  
Larisa Alexandrovna Balykova ◽  
Svetlana Vasilyevna Garina ◽  
Olga Nikolaevna Soldatova ◽  
A A Tolkunova ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Lipid Metabolism ◽  
Red Blood Cells ◽  
Brain Damage ◽  
Blood Cells ◽  
Phospholipid Bilayer ◽  
Care Practice ◽  
Perinatal Morbidity ◽  
The Central Nervous System

The problem of perinatal morbidity in case of insufficiently high fertility in Russia is one of the most relevant at the monent. The leading cause of perinatal morbidity and mortality continue to remain hypoxic-ischemic brain damage the fetus and newborn. Ischemic-hypoxic damage of the central nervous system (CNS) is the most dangerous and prognostic significance. They often fatal and takes a leading role in the future of children and maladjustment of severe disabling diseases. Introduction of innovative medical technologies in health care practice greatly enhances the study of the causes of many diseases and abnormalities in newborns and helps to clarify the etiology, pathogenetic mechanisms, clinical and morphological structure, as well as typical for different gestational age localization of brain damage. It is shown that the generalized disorder of lipid metabolism with the development membranodestruktive processes is closely correlated with the severity of hypoxic-ischemic lesions of the central nervous system. It was found that infants who underwent antenatal and / or intranatal hypoxia, there are significant transformation of lipid metabolism lead to changes in the composition of lipids of blood plasma and red blood cells (with the accumulation level of chaotropic fractions phospholipid bilayer membranes of red blood cells - Lizoform phospholipids and free fatty acids). The necessity inclusion complex therapy consequences of perinatal hypoxia drugs, which have antioxidant, antihypoxic activity and the ability to regulate lipid metabolism.

The effect of central nervous system(CNS) lesion on lipid metabolism in rat liver

1985 ◽  
Vol 1 ◽  
pp. S23
Author(s):  
Shunichi Murano ◽  
Kohji Shirai ◽  
Yasushi Saito ◽  
Sho Yoshida
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Lipid Metabolism ◽  
Rat Liver

scholarly journals Autonomic nervous system-mediated effects of galanin-like peptide on lipid metabolism in liver and adipose tissue

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Satoshi Hirako ◽  
Nobuhiro Wada ◽  
Haruaki Kageyama ◽  
Fumiko Takenoya ◽  
Yoshihiko Izumida ◽  
...  
Keyword(s):  
Nervous System ◽  
Adipose Tissue ◽  
Autonomic Nervous System ◽  
Lipid Metabolism ◽  
Autonomic Nervous ◽  
Mediated Effects
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