Role of Text Mining in Early Identification of Potential Drug Safety Issues

2014 ◽  
pp. 227-251 ◽  
Author(s):  
Mei Liu ◽  
Yong Hu ◽  
Buzhou Tang
Keyword(s):  
Text Mining ◽  
Drug Safety ◽  
Early Identification ◽  
Potential Drug ◽  
Safety Issues

scholarly journals The pharmacoepidemiology of potential drug-drug interactions in patients with psychiatric disorders

2020 ◽  
pp. 85-92
Author(s):  
O. O. Kirilochev ◽  
A. R. Umerova
Keyword(s):  
Drug Interactions ◽  
Psychiatric Disorders ◽  
Clinical Significance ◽  
Drug Safety ◽  
Treatment Resistance ◽  
Drug Combinations ◽  
Mental Illnesses ◽  
Potential Drug ◽  
Safety Issues ◽  
Age Related

Actuality. Drug safety issues in patients with psychiatric disorders are relevant due to specifics of clinical pharmacology of the medicinal products used, possible treatment-resistance of mental illnesses and concomitant use of multiple antipsychotic drugs. One of the aspects of treatment safety is a prediction of drug-drug interactions.The aim of the study was to analyze potential drug-drug interactions in patients with psychiatric disorders.Materials and methods. The study enrolled 500 patients with psychiatric disorders in two age-related groups. Drug therapy was analyzed to reveal potential cases of drug-drug interactions.Results. A total of 1 031 cases of the use of drug combinations leading to drug-drug interactions of various clinical significance were revealed in 72.4 % of patients. There were significant differences between two age-related groups in respect of the specifics of medications use and clinical significance of drug combinations.Conclusion. Prediction of drug-drug interactions is likely to ensure improved drug safety in patients with psychiatric disorders.

Using serum biomarkers for identifying unstable carotid plaque: update of current evidence

2020 ◽  
Vol 26 ◽  
Author(s):  
Areti Sofogianni ◽  
Konstantinos Tziomalos ◽  
Triantafyllia Koletsa ◽  
Apostolos G. Pitoulias ◽  
Lemonia Skoura ◽  
...  
Keyword(s):  
High Risk ◽  
Great Proportion ◽  
Current Literature ◽  
Early Identification ◽  
Carotid Plaque ◽  
Potential Role ◽  
Carotid Atherosclerosis ◽  
Serum Biomarkers ◽  
Current Evidence

: Carotid atherosclerosis is responsible for a great proportion of ischemic strokes. Early identification of unstable or vulnerable carotid plaques and therefore of patients at high risk for stroke is of significant medical and socioeconomical value. We reviewed the current literature and discuss the potential role of the most important serum biomarkers in identifying patients with carotid atherosclerosis who are at high risk for atheroembolic stroke.

Structure, Function and Interactions of Tau: Particular Focus on Potential Drug Targets for the Treatment of Tauopathies

2018 ◽  
Vol 17 (5) ◽  
pp. 325-337 ◽  
Author(s):  
Hojjat Borna ◽  
Kasim Assadoulahei ◽  
Gholamhossein Riazi ◽  
Asghar Beigi Harchegani ◽  
Alireza Shahriary
Keyword(s):  
Tau Protein ◽  
Drug Targets ◽  
Brain Injuries ◽  
Potential Drug ◽  
Microtubule Network ◽  
Wide Range ◽  
Potential Risk Factors ◽  
Range Of Functions ◽  
Potential Drug Targets

Background & Objective: Neurodegenrative diseases are among the most widespread lifethreatening disorders around the world in elderly ages. The common feature of a group of neurodegenerative disorders, called tauopathies, is an accumulation of microtubule associated protein tau inside the neurons. The exact mechanism underlying tauopathies is not well-understood but several factors such as traumatic brain injuries and genetics are considered as potential risk factors. Although tau protein is well-known for its key role in stabilizing and organization of axonal microtubule network, it bears a broad range of functions including DNA protection and participation in signaling pathways. Moreover, the flexible unfolded structure of tau facilitates modification of tau by a wide range of intracellular enzymes which in turn broadens tau function and interaction spectrum. The distinctive properties of tau protein concomitant with the crucial role of tau interaction partners in the progression of neurodegeneration suggest tau and its binding partners as potential drug targets for the treatment of neurodegenerative diseases. Conclusion: This review aims to give a detailed description of structure, functions and interactions of tau protein in order to provide insight into potential therapeutic targets for treatment of tauopathies.

Statutory Safety Representatives and Safety Committees: Legal and Industrial Relations Implications

1982 ◽  
Vol 24 (3) ◽  
pp. 337-364 ◽  
Author(s):  
W.B. Creighton
Keyword(s):  
Industrial Relations ◽  
Health And Safety ◽  
Safety Issues ◽  
Statutory Provision ◽  
The United Kingdom ◽  
Sufficient Detail ◽  
Structured System ◽  
Safety Committees ◽  
Practical Implications

This article examines the increasingly important issue of the role of statutory safety representatives and safety committees in helping to promote and protect the health, safety and welfare of the Australian workforce. It consists first of an examination of the development of statutory provision in this area in the United Kingdom, culminating in the passing of the Health and Safety at Work Act 1974 and the introduction of the far-reaching Safety Representatives and Safety Committees Regulations of 1977. It then describes and analyses the reception of these provisions, and the philosophy which underpins them, in Australia. Thirdly, it attempts to identify and discuss some of the more important legal and practical implications of this kind of statutory provision. There is reason to suppose that some of these issues have not been analysed in sufficient detail in either Britain or Australia, but overall it is clear that a properly structured system of statutory safety representatives/com mittees can play an important and constructive part in helping to promote a proper awareness of health and safety issues in this country.

Text mining for economic geographical sectoral analysis of the pulp and paper industry in European Russia

2021 ◽  
Vol 71 (1) ◽  
pp. 18-33
Author(s):  
I.F. Kuzminov ◽  
P.A. Lobanova
Keyword(s):  
Text Mining ◽  
Paper Industry ◽  
Pulp And Paper Industry ◽  
Spatial Development ◽  
Pulp And Paper ◽  
European Russia ◽  
Data Sources ◽  
Management Decisions ◽  
Timber Industry

The authors show the need and some existing opportunities for analysis of non-traditional data sources to obtain a complete and more relevant picture of industries spatial development. The research methodology includes the use of text mining for economic and geographical studies. The relevance of the research is determined by insufficient completeness of official statistical data, cheapening of relevant information processing technologies and abundance of large text data sources in open access. The article discusses the role of the pulp and paper industry (as a key part of the timber industry) in economic and spatial development of modern Russia. The authors identify main trends in the economic and spatial development of the pulp and paper industry of European Russia, draw the conclusions on the expected industry trends and give recommendations for strategic management decisions to respond to industry challenges. The authors claim that the industry needs liberalization and stabilization, primarily through moratoriums on policy changes. The role of the use of big data, and in particular of text mining in economic and geographical research for reasonable and objective conclusions formation that can be used to make timely and balanced management decisions in the timber industry and the pulp and paper industry, is emphasized.

Sentiment Analysis with Text Mining in Contexts of Big Data

2017 ◽  
Vol 13 (3) ◽  
pp. 47-67 ◽  
Author(s):  
Carina Sofia Andrade ◽  
Maribel Yasmina Santos
Keyword(s):  
Big Data ◽  
Text Mining ◽  
Sentiment Analysis ◽  
Decision Making Process ◽  
Practical Applications ◽  
Information Models ◽  
Evolution Of Technology ◽  
The Common ◽  
Analyse Data

The evolution of technology, along with the common use of different devices connected to the Internet, provides a vast growth in the volume and variety of data that are daily generated at high velocity, phenomenon commonly denominated as Big Data. Related with this, several Text Mining techniques make possible the extraction of useful insights from that data, benefiting the decision-making process across multiple areas, using the information, models, patterns or tendencies that these techniques are able to identify. With Sentiment Analysis, it is possible to understand which sentiments and opinions are implicit in this data. This paper proposes an architecture for Sentiment Analysis that uses data from the Twitter, which is able to collect, store, process and analyse data on a real-time fashion. To demonstrate its utility, practical applications are developed using real world examples where Sentiment Analysis brings benefits when applied. With the presented demonstration case, it is possible to verify the role of each used technology and the techniques adopted for Sentiment Analysis.

Hydrotesting and In-Line Inspection: Now and in the Future

2016 ◽  
Author(s):  
Jerry Rau ◽  
Mike Kirkwood
Keyword(s):  
New Technologies ◽  
Inert Gases ◽  
Alternative Methods ◽  
Operating Pressure ◽  
Inherent Safety ◽  
Safety Issues ◽  
The Future ◽  
Integrity Assurance ◽  
High Level

Pressure testing of pipelines has been around in some form or another since the 1950s1–14. In its earliest form, operators used inert gases such as Nitrogen or even air to test for pipeline integrity. However, with the significant increases in pipeline pressures and inherent safety issues with a pressurized gas, the switch to using water happened in the late 1960’s15–17. Hydrostatic tests (referred to as hydrotests) have been used since then to set and reset the Maximum Allowable Operating Pressure (MAOP) for pipelines but as other technologies develop and gain acceptance will hydrotesting still play a key role in pipeline integrity in the years ahead? Currently, hydrotesting is a topic for the impending US Pipeline and Hazardous Materials Safety Administration’s (PHMSA) Proposed New Rule Making (PNRM)18. Under the NPRM, hydrotesting is required to verify MAOP on pre-1970s US “grandfathered” pipelines, as well as on pipelines of any age with incomplete or missing testing record and include a high level test with a “spike” in pressure. But hydrotesting may not be the only method. Alternative methods and new technologies — used alone or used in combination with hydrotesting — may help provide a more comprehensive way for operators to identify and address potential problems before they become a significant threat. This paper explores both sides of the argument. Before In-Line Inspection (ILI) technology was even available, hydrotesting was the absolute means of the proof of integrity. However, hydrotesting is under scrutiny for many reasons that this paper explores. ILI was introduced in the 1960’s with the first commercially available Magnetic Flux Leakage (MFL) tools that presented the industry with an alternative. Currently there are a huge array of available technologies on an ILI tool and so is the role of the hydrotest over? The paper looks at the benefits of the hydrotest and these are presented and balanced against available ILI technology. Furthermore, as pipelines are being developed in even more harsh environments such as deepwater developments, the actual logistics of performing a hydrotest become more challenging. The paper will also look at both applications onshore and offshore where regulators have accepted waivers to a hydrotest using alternative methods of proving integrity. The paper concludes with the current use and needs for hydrotesting, the regulatory viewpoint, the alternatives and also what the future developments need to focus on and how technology may be improved to provide at least a supplement if not a replacement to this means of integrity assurance.

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