Systemic RNA Interference in Planarians by Feeding of dsRNA Containing Bacteria

2018 ◽  
pp. 445-454 ◽  
Author(s):  
Carolyn E. Adler ◽  
Alejandro Sánchez Alvarado
Keyword(s):  
Rna Interference ◽  
Systemic Rna

scholarly journals Inducible Systemic RNA Silencing in Caenorhabditis elegans

2003 ◽  
Vol 14 (7) ◽  
pp. 2972-2983 ◽  
Author(s):  
Lisa Timmons ◽  
Hiroaki Tabara ◽  
Craig C. Mello ◽  
Andrew Z. Fire
Keyword(s):  
Rna Interference ◽  
Caenorhabditis Elegans ◽  
Rna Silencing ◽  
Molecular Mechanisms ◽  
Normal Animal ◽  
Cell Types ◽  
Animal Cells ◽  
Tissue Specific ◽  
C Elegans ◽  
Systemic Rna

Introduction of double-stranded RNA (dsRNA) can elicit a gene-specific RNA interference response in a variety of organisms and cell types. In many cases, this response has a systemic character in that silencing of gene expression is observed in cells distal from the site of dsRNA delivery. The molecular mechanisms underlying the mobile nature of RNA silencing are unknown. For example, although cellular entry of dsRNA is possible, cellular exit of dsRNA from normal animal cells has not been directly observed. We provide evidence that transgenic strains of Caenorhabditis elegans transcribing dsRNA from a tissue-specific promoter do not exhibit comprehensive systemic RNA interference phenotypes. In these same animals, modifications of environmental conditions can result in more robust systemic RNA silencing. Additionally, we find that genetic mutations can influence the systemic character of RNA silencing in C. elegans and can separate mechanisms underlying systemic RNA silencing into tissue-specific components. These data suggest that trafficking of RNA silencing signals in C. elegans is regulated by specific physiological and genetic factors.

scholarly journals Antiviral immunity in Drosophila requires systemic RNA interference spread

Nature ◽  
2009 ◽  
Vol 458 (7236) ◽  
pp. 346-350 ◽  
Author(s):  
Maria-Carla Saleh ◽  
Michel Tassetto ◽  
Ronald P. van Rij ◽  
Bertsy Goic ◽  
Valérie Gausson ◽  
...  
Keyword(s):  
Rna Interference ◽  
Antiviral Immunity ◽  
Systemic Rna

Vacuolar (H + )‐ ATPase subunit c is essential for the survival and systemic RNA interference response in Locusta migratoria

2022 ◽  
Author(s):  
Xuekai Shi ◽  
Xiaojian Liu ◽  
Anastasia M.W. Cooper ◽  
Kristopher Silver ◽  
Hans Merzendorfer ◽  
...  
Keyword(s):  
Rna Interference ◽  
Locusta Migratoria ◽  
Atpase Subunit ◽  
Subunit C ◽  
Systemic Rna ◽  
Interference Response

scholarly journals Scavenger Receptor Mediates Systemic RNA Interference in Ticks

PLoS ONE ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. e28407 ◽  
Author(s):  
Kyaw Min Aung ◽  
Damdinsuren Boldbaatar ◽  
Rika Umemiya-Shirafuji ◽  
Min Liao ◽  
Xuan Xuenan ◽  
...  
Keyword(s):  
Rna Interference ◽  
Scavenger Receptor ◽  
Systemic Rna
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