S100 Proteins as Biomarkers in Risk Estimations for Malignant Transformation in Oral Lesions

2019 ◽  
pp. 763-771
Author(s):  
Rainer Probstmeier ◽  
Dominik Kraus ◽  
Matthias Wenghoefer ◽  
Jochen Winter
Keyword(s):  
Malignant Transformation ◽  
S100 Proteins ◽  
Oral Lesions

scholarly journals Incorporation of differentiated dysplasia improves prediction of oral leukoplakia at increased risk of malignant progression

2020 ◽  
Vol 33 (6) ◽  
pp. 1033-1040 ◽  
Author(s):  
Leon J. Wils ◽  
Jos B. Poell ◽  
Ilkay Evren ◽  
Marit S. Koopman ◽  
Elisabeth R. E. A. Brouns ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
World Health Organization ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Malignant Progression ◽  
Oral Leukoplakia ◽  
World Health ◽  
Oral Lesions ◽  
Health Organization

AbstractOral leukoplakia is the most common oral potentially malignant disorder with a malignant transformation rate into oral squamous cell carcinoma of 1–3% annually. The presence and grade of World Health Organization defined dysplasia is an important histological marker to assess the risk for malignant transformation, but is not sufficiently accurate to personalize treatment and surveillance. Differentiated dysplasia, known from differentiated vulvar intraepithelial neoplasia, is hitherto not used in oral dysplasia grading. We hypothesized that assessing differentiated dysplasia besides World Health Organization defined (classic) dysplasia will improve risk assessment of malignant transformation of oral leukoplakia. We investigated a retrospective cohort consisting of 84 oral leukoplakia patients. Biopsies were assessed for dysplasia presence and grade, and the expression of keratins 13 (CK13) and 17, known to be dysregulated in dysplastic vulvar mucosa. In dysplastic oral lesions, differentiated dysplasia is as common as classic dysplasia. In 25 out of 84 (30%) patients, squamous cell carcinoma of the upper aerodigestive tract developed during follow-up. Considering only classic dysplasia, 11 out of 56 (20%) patients with nondysplastic lesions progressed. With the incorporation of differentiated dysplasia, only 2 out of 30 (7%) patients with nondysplastic lesions progressed. The risk of progression increased from 3.26 (Hazard ratio, p = 0.002) when only classic dysplasia is considered to 7.43 (Hazard ratio, p = 0.001) when classic and differentiated dysplasia are combined. Loss of CK13, combined with presence of dysplasia, is associated with greater risk of malignant progression (p = 0.006). This study demonstrates that differentiated dysplasia should be recognized as a separate type of dysplasia in the oral mucosa and that its distinction from classic dysplasia is of pathological and clinical significance since it is a strong (co)prognostic histopathological marker for oral malignant transformation. In oral lesions without dysplasia and retained CK13 staining the risk for progression is very low.

scholarly journals Expression of invadopodia markers can identify oral lesions with a high risk of malignant transformation

2020 ◽  
Vol 7 (1) ◽  
pp. 61-74
Author(s):  
Aiman Ali ◽  
Andresa Borges Soares ◽  
Denise Eymael ◽  
Marco Magalhaes
Keyword(s):  
High Risk ◽  
Malignant Transformation ◽  
Oral Lesions

ZNF582 Hypermethylation as a Prognostic Biomarker for Malignant Transformation of Oral Lesions

Oral Diseases ◽  
2021 ◽  
Author(s):  
Yi‐Chen Juan ◽  
Yee‐Fun Su ◽  
Chyi‐Huey Bai ◽  
Yen‐Chun Fan ◽  
Tzu‐Tung Kuo ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Prognostic Biomarker ◽  
Oral Lesions

scholarly journals Immunohistochemical Study of Laminin-332 γ2 Chain and MMP-9 in High Risk of Malignant Transformation Oral Lesions and OSCC

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Eline Manhães Reid Silva ◽  
Vanessa Morais Freitas ◽  
Willian Grassi Bautz ◽  
Liliana Aparecida Pimenta de Barros ◽  
Letícia Nogueira da Gama de Souza
Keyword(s):  
High Risk ◽  
Malignant Transformation ◽  
Immunohistochemical Study ◽  
Oral Lesions ◽  
Laminin 332

scholarly journals PCNA and p53 expression in oral leukoplakia with different degrees of keratinization

2006 ◽  
Vol 14 (4) ◽  
pp. 276-280 ◽  
Author(s):  
Melaine de Almeida Lawall ◽  
Marcelo Macedo Crivelini
Keyword(s):  
Expression Pattern ◽  
Malignant Transformation ◽  
Oral Mucosa ◽  
Clinical Aspect ◽  
Oral Leukoplakia ◽  
Oral Lesions ◽  
Immunohistochemical Expression ◽  
P53 Expression ◽  
Epithelial Layers ◽  
Epithelial Keratinization

Leukoplakias are oral lesions that may have many clinical and histological aspects and they are usually associated with malignancy when dysplastic alterations are shown. However, these transformations may occur in non-dysplastic lesions that show harmless clinical aspect. For this reason, the proposal was to study the p53 and PCNA immunohistochemical expression in non-dysplastic leukoplakias, trying to correlate the results only with the epithelial keratinization degree. For this, 24 leukoplakias degrees I, II and III of Grinspan were used, all of them located in oral mucosa. Most of the leukoplakias showed p53 and PCNA expression in their different keratinization degrees. The p53 marking was confined to the basal and parabasal layers, while the PCNA marking occurred in practically all epithelial layers. The expression pattern of these markers was histologically and statistically similar between the lesions with these keratinization variations. It was evident that non-dysplastic epithelium of leukoplakias showed submicroscopical signs of alterations that lead to malignant transformation, and that the keratinization degree did not correlate to a greater risk of this event.

scholarly journals Between-Lesion Discrepancies in Terms of Dysplasia, Cell Turnover and Diagnosis in Patients with Multiple Potentially Malignant Oral Lesions

2013 ◽  
Vol 7 (1) ◽  
pp. 169-174 ◽  
Author(s):  
Montebugnoli Lucio ◽  
Gabusi Andrea ◽  
Gissi Davide Bartolomeo ◽  
Cervellati Fabio ◽  
Servidio Dora
Keyword(s):  
Malignant Transformation ◽  
Oral Mucosa ◽  
Final Diagnosis ◽  
Clinical Aspect ◽  
Oral Lesions ◽  
Cell Turnover ◽  
High Cell ◽  
Multiple Biopsies ◽  
Potentially Malignant ◽  
Single Lesion

Objective: The present study assessed patients with multiple oral lesions to evaluate the mis-estimation rate in terms of diagnosis and risk of malignant transformation when only one biopsy is performed. Study Design: Thirty-five patients presenting at least two white and/or red lesions in different oral mucosa sites with a final diagnosis of leuko/erythroplakias or lichenoid lesions were included, for a total of 70 biopsies. Results: Nineteen patients (54%) had at least one between-lesion discrepancy considering the presence/absence of dysplasia (10 patients), normal/high cell turnover (13 patients) or diagnosis (5 patients). Discrepancies were not related to clinical aspect or within-patient similarity of lesions. Conclusions: Multiple oral lesions in the same patient can significantly differ in terms of dysplasia, high cell turnover and, even diagnosis. Multiple biopsies are imperative and diagnosis as well as risk of malignant transformation should be formulated for each single lesion rather than for each individual patient.

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