Prolactin in Human Breast Cancer Development

2000 ◽  
pp. 101-120 ◽  
Author(s):  
Barbara K. Vonderhaar
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Cancer Development ◽  
Human Breast ◽  
Breast Cancer Development

scholarly journals Abstract 1839: TGFBR1*6A mouse model mimics human breast cancer development and progression

2017 ◽  
Author(s):  
Michael James Pennison ◽  
Minghui Wang ◽  
Hugo Jimenez ◽  
Boris Pasche
Keyword(s):  
Breast Cancer ◽  
Mouse Model ◽  
Human Breast Cancer ◽  
Cancer Development ◽  
Human Breast ◽  
Breast Cancer Development

Mice Expressing a Mammary Gland–Specific R270H Mutation in the p53 Tumor Suppressor Gene Mimic Human Breast Cancer Development

2005 ◽  
Vol 65 (18) ◽  
pp. 8166-8173 ◽  
Author(s):  
Susan W.P. Wijnhoven ◽  
Edwin Zwart ◽  
Ewoud N. Speksnijder ◽  
Rudolf B. Beems ◽  
Kenneth P. Olive ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Human Breast Cancer ◽  
Suppressor Gene ◽  
Cancer Development ◽  
Human Breast ◽  
Breast Cancer Development ◽  
P53 Tumor Suppressor Gene

MCF‐10AT: A Model for Human Breast Cancer Development

1999 ◽  
Vol 5 (2) ◽  
pp. 122-129 ◽  
Author(s):  
Gloria H. Heppner ◽  
Sandra R. Wolman
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Cancer Development ◽  
Human Breast ◽  
Breast Cancer Development

Prolactin in Human Breast Cancer Development

2003 ◽  
pp. 101-120 ◽  
Author(s):  
Barbara K. Vonderhaar
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Cancer Development ◽  
Human Breast ◽  
Breast Cancer Development

scholarly journals Endothelial Protein C Receptor Function in Murine and Human Breast Cancer Development

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e61071 ◽  
Author(s):  
Florence Schaffner ◽  
Naho Yokota ◽  
Tatiana Carneiro-Lobo ◽  
Maki Kitano ◽  
Michael Schaffer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Protein C ◽  
Cancer Development ◽  
Receptor Function ◽  
Human Breast ◽  
Endothelial Protein C Receptor ◽  
Breast Cancer Development

scholarly journals MRCKα Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 942
Author(s):  
Mei Qi Kwa ◽  
Rafael Brandao ◽  
Trong H. Phung ◽  
Jianfeng Ge ◽  
Giuseppe Scieri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression Signature ◽  
Genomic Analysis ◽  
Cancer Development ◽  
Breast Cancer Cell Lines ◽  
Normal Mammary Gland ◽  
Breast Cancers ◽  
Human Breast ◽  
Breast Cancer Development

MRCKα is a ubiquitously expressed serine/threonine kinase involved in cell contraction and F-actin turnover, which is highly amplified in human breast cancer and part of a gene expression signature for bad prognosis. Nothing is known about the in vivo function of MRCKα. To explore MRCKα function in development and in breast cancer, we generated mice lacking a functional MRCKα gene. Mice were born close to the Mendelian ratio and showed no obvious phenotype including a normal mammary gland formation. Assessing breast cancer development using the transgenic MMTV-PyMT mouse model, loss of MRCKα did not affect tumor onset, tumor growth and metastasis formation. Deleting MRCKα and its related family member MRCKβ in two triple-negative breast cancer cell lines resulted in reduced invasion of MDA-MB-231 cells, but did not affect migration of 4T1 cells. Further genomic analysis of human breast cancers revealed that MRCKα is frequently co-amplified with the oncogenes ARID4B and AKT3 which might contribute to the prognostic value of MRCKα expression. Collectively, these data suggest that MRCKα might be a prognostic marker for breast cancer, but probably of limited functional importance.

scholarly journals Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer

Cancers ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 409 ◽  
Author(s):  
Khaldoun Rifaï ◽  
Mouhamed Idrissou ◽  
Frédérique Penault-Llorca ◽  
Yves-Jean Bignon ◽  
Dominique Bernard-Gallon
Keyword(s):  
Breast Cancer ◽  
Histone Deacetylase ◽  
Human Breast Cancer ◽  
Cancer Metastasis ◽  
Sirtuin 1 ◽  
Cancer Development ◽  
Class Iii ◽  
Human Breast ◽  
Breast Tumorigenesis ◽  
Attractive Therapeutic Target

Breast cancer (BC) is the most common type of cancer in women worldwide; it is a multifactorial genetic disease. Acetylation and deacetylation are major post-translational protein modifications that regulate gene expression and the activity of a myriad of oncoproteins. Aberrant deacetylase activity can promote or suppress tumorigenesis and cancer metastasis in different types of human cancers, including breast cancer. Sirtuin-1 (SIRT1) is a class-III histone deacetylase (HDAC) that deacetylates both histone and non-histone targets. The often-described ‘regulator of regulators’ is deeply implicated in apoptosis, gene regulation, genome maintenance, DNA repair, aging, and cancer development. However, despite the accumulated studies over the past decade, the role of SIRT1 in human breast cancer remains a subject of debate and controversy. The ambiguity surrounding the implications of SIRT1 in breast tumorigenesis stems from the discrepancy between studies, which have shown both tumor-suppressive and promoting functions of SIRT1. Furthermore, studies have shown that SIRT1 deficiency promotes or suppresses tumors in breast cancer, making it an attractive therapeutic target in cancer treatment. This review provides a comprehensive examination of the various implications of SIRT1 in breast cancer development and metastasis. We will also discuss the mechanisms underlying the conflicting roles of SIRT1, as well as its selective modulators, in breast carcinogenesis.

Alteration of α-tocopherol-associated protein (TAP) expression in human breast epithelial cells during breast cancer development

2013 ◽  
Vol 138 (2-3) ◽  
pp. 1015-1021 ◽  
Author(s):  
Ka-Wai Tam ◽  
Chi-Tang Ho ◽  
Wen-Jui Lee ◽  
Shih-Hsin Tu ◽  
Ching-Shui Huang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epithelial Cells ◽  
Cancer Development ◽  
Human Breast ◽  
Breast Epithelial Cells ◽  
Breast Cancer Development ◽  
Breast Epithelial ◽  
Human Breast Epithelial Cells
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