Role of Host Genetics in Lymphoma

2009 ◽  
pp. 545-552
Author(s):  
Ahmet Dogan
Keyword(s):  
Host Genetics

scholarly journals The Role of Host Genetics in the Susceptibility for HIV-associated Neurocognitive Disorders

2008 ◽  
Vol 13 (1) ◽  
pp. 118-132 ◽  
Author(s):  
Andrew J. Levine ◽  
Elyse J. Singer ◽  
Paul Shapshak
Keyword(s):  
Neurocognitive Disorders ◽  
Host Genetics ◽  
Hiv Associated Neurocognitive Disorders

The role of human host genetics in tuberculosis resistance

2017 ◽  
Vol 11 (9) ◽  
pp. 721-737 ◽  
Author(s):  
Craig Kinnear ◽  
Eileen G. Hoal ◽  
Haiko Schurz ◽  
Paul D. van Helden ◽  
Marlo Möller
Keyword(s):  
Host Genetics ◽  
Human Host

scholarly journals Role of host genetics in fibrosis

2009 ◽  
Vol 2 (1) ◽  
Author(s):  
Georgina L Hold ◽  
Paraskevi Untiveros ◽  
Karin A Saunders ◽  
Emad M El-Omar
Keyword(s):  
Host Genetics

scholarly journals Individual susceptibility to arsenic-induced diseases: the role of host genetics, nutritional status, and the gut microbiome

2018 ◽  
Vol 29 (1-2) ◽  
pp. 63-79 ◽  
Author(s):  
Liang Chi ◽  
Bei Gao ◽  
Pengcheng Tu ◽  
Chih-Wei Liu ◽  
Jingchuan Xue ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Gut Microbiome ◽  
Host Genetics ◽  
Individual Susceptibility

scholarly journals The Role of Host Genetics in Susceptibility to Influenza: A Systematic Review

PLoS ONE ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. e33180 ◽  
Author(s):  
Peter Horby ◽  
Nhu Y. Nguyen ◽  
Sarah J. Dunstan ◽  
J. Kenneth Baillie
Keyword(s):  
Systematic Review ◽  
Influenza A ◽  
Host Genetics

scholarly journals Host genetic associations with the gut microbiota in HIV-1-infected subjects: a pilot exploratory study

2018 ◽  
Author(s):  
Yolanda Guillén ◽  
Marc Noguera-Julian ◽  
Javier Rivera ◽  
Maria Casadellà ◽  
Muntsa Rocafort ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Methanogenic Archaea ◽  
Genetic Associations ◽  
Host Genetics ◽  
Genetic Landscape ◽  
Host Genetic ◽  
Gene Richness ◽  
The Impact ◽  
Hiv 1

AbstractThe impact of host genetics on gut microbial dynamics is debated. No study to date has investigated the possible role of host genetics in shaping the gut microbiota in HIV-1 infected subjects. With the aim of generating preliminary data to inform future host genetic studies, we performed an exploratory host exome analysis of 147 subjects either infected or at risk of becoming infected with HIV-1 from the MetaHIV cohort in Barcelona. Using a DNA microarray chip, we sought to identify host genetic variants associated to three specific microbial features with a potentially inheritable component, and which were previously found to be associated with gut dysbiosis in HIV infection, i.e.: gut enterotype, presence of methanogenic archaea and microbial gene richness. After correction for multiple comparisons, we did not observe any statistically significant association between the host’s genetic landscape and the explored gut microbiome traits. These findings will help design future, adequately-powered studies to assess the influence of host genetics in the microbiome of HIV-1-infected subjects.

scholarly journals Acquisition of Oral Microbiota is Driven by Environment, Not Host Genetics

2020 ◽  
Author(s):  
Chiranjit Mukherjee ◽  
Christina O. Moyer ◽  
Heidi M. Steinkamp ◽  
Shahr B. Hashmi ◽  
Xiaohan Guo ◽  
...  
Keyword(s):  
Genetic Relatedness ◽  
Bacterial Species ◽  
Oral Microbiome ◽  
Individual Species ◽  
Shared Environment ◽  
Oral Microbiota ◽  
Host Genetics ◽  
Early Effects ◽  
The Many

Abstract Background: The oral microbiota is acquired very early, but the factors shaping its acquisition are not well understood. Previous studies comparing monozygotic (MZ) and dizygotic (DZ) twins have suggested that host genetics plays a role. However, all twins share an equal portion of their parent’s genome, so this model is not informative for studying parent-to-child transmission. We used a novel study design that allowed us to directly examine the genetics of transmission by comparing the oral microbiota of biological versus adoptive mother-child dyads. Results: No difference was observed in how closely oral bacterial community profiles matched for adoptive versus biological mother-child pairs, indicating little if any effect of host genetics on the fidelity of transmission. Both adopted and biologic children more closely resembled their own mother as compared to unrelated women, supporting the role of contact and environment. Mother-child strain similarity increased with the age of the child, ruling out early effects of host genetic influence that are lost over time. No effect on the fidelity of mother-child strain sharing from vaginal birth or breast feeding was seen. Analysis of extended families showed that fathers and mothers were equally similar to their children, and that cohabitating couples showed even greater strain similarity than mother-child pairs. These findings support the role of contact and shared environment, and age, but not genetics, as determinants of microbial transmission, and were consistent at both species and strain level resolutions, and across multiple oral habitats. In addition, analysis of individual species all showed similar results. Conclusions: The host is clearly active in shaping the composition of the oral microbiome, since only a few of the many bacterial species in the larger environment are capable of colonizing the human oral cavity. Our findings suggest that these host mechanisms are universally shared among humans, since no effect of genetic relatedness on fidelity of microbial transmission could be detected. Instead our findings point towards contact and shared environment being the driving factors of microbial transmission, with a unique combination of these factors ultimately shaping the highly personalized human oral microbiome.

scholarly journals Tumor microbiome contributes to an aggressive phenotype in the basal-like subtype of pancreatic cancer

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Wei Guo ◽  
Yuchao Zhang ◽  
Shiwei Guo ◽  
Zi Mei ◽  
Huiping Liao ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Functional Characterization ◽  
Comprehensive Analysis ◽  
Metagenomic Sequencing ◽  
Tumor Subtype ◽  
Disease Heterogeneity ◽  
Host Genetics ◽  
Aggressive Tumor

AbstractDespite the uniform mortality in pancreatic adenocarcinoma (PDAC), clinical disease heterogeneity exists with limited genomic differences. A highly aggressive tumor subtype termed ‘basal-like’ was identified to show worse outcomes and higher inflammatory responses. Here, we focus on the microbial effect in PDAC progression and present a comprehensive analysis of the tumor microbiome in different PDAC subtypes with resectable tumors using metagenomic sequencing. We found distinctive microbial communities in basal-like tumors and identified an increasing abundance of Acinetobacter, Pseudomonas and Sphingopyxis to be highly associated with carcinogenesis. Functional characterization of microbial genes suggested the potential to induce pathogen-related inflammation. Host-microbiota interplay analysis provided new insights into the tumorigenic role of specific microbiome compositions and demonstrated the influence of host genetics in shaping the tumor microbiome. Taken together, these findings indicated that the tumor microbiome is closely related to PDAC oncogenesis and the induction of inflammation. Additionally, our data revealed the microbial basis of PDAC heterogeneity and proved the predictive value of the microbiome, which will contribute to the intervention and treatment of disease.

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