Identification of MAP Kinase Pathways Involved in COX-2 Expression Following Photofrin Photodynamic Therapy

2010 ◽  
pp. 47-63 ◽  
Author(s):  
Marian Luna ◽  
Angela Ferrario ◽  
Sam Wong ◽  
Charles J. Gomer
Keyword(s):  
Photodynamic Therapy ◽  
Map Kinase ◽  
Cox 2 ◽  
Map Kinase Pathways

MAP Kinase Pathways as a Route for Regulatory Mechanisms of IL-10 and IL-4 Which Inhibit COX-2 Expression in Human Monocytes

1998 ◽  
Vol 250 (2) ◽  
pp. 200-205 ◽  
Author(s):  
Hiroaki Niiro ◽  
Takeshi Otsuka ◽  
Eiichi Ogami ◽  
Kunihiro Yamaoka ◽  
Shuji Nagano ◽  
...  
Keyword(s):  
Map Kinase ◽  
Regulatory Mechanisms ◽  
Human Monocytes ◽  
Cox 2 ◽  
Map Kinase Pathways

scholarly journals Differential involvement of NF-κB and MAP kinase pathways in the generation of inflammatory cytokines by human neutrophils

2006 ◽  
Vol 81 (2) ◽  
pp. 567-577 ◽  
Author(s):  
Alexandre Cloutier ◽  
Thornin Ear ◽  
Emilie Blais-Charron ◽  
Claire M. Dubois ◽  
Patrick P. McDonald
Keyword(s):  
Map Kinase ◽  
Inflammatory Cytokines ◽  
Human Neutrophils ◽  
Differential Involvement ◽  
Map Kinase Pathways

scholarly journals Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*

2001 ◽  
Vol 22 (2) ◽  
pp. 153-183 ◽  
Author(s):  
Gray Pearson ◽  
Fred Robinson ◽  
Tara Beers Gibson ◽  
Bing-e Xu ◽  
Mahesh Karandikar ◽  
...  
Keyword(s):  
Map Kinase ◽  
Physiological Functions ◽  
Protein Map ◽  
Mitogen Activated Protein ◽  
Map Kinase Pathways

TOR and MAP kinase pathways synergistically regulate autophagy in response to nutrient depletion in fission yeast

Autophagy ◽  
2021 ◽  
pp. 1-16
Author(s):  
Cristina Corral-Ramos ◽  
Rubén Barrios ◽  
José Ayté ◽  
Elena Hidalgo
Keyword(s):  
Map Kinase ◽  
Fission Yeast ◽  
Nutrient Depletion ◽  
Map Kinase Pathways

Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3–CA1 synapses

10.1038/80624 ◽  
2000 ◽  
Vol 3 (11) ◽  
pp. 1107-1112 ◽  
Author(s):  
V. Y. Bolshakov ◽  
L. Carboni ◽  
M.H. Cobb ◽  
S. A. Siegelbaum ◽  
F. Belardetti
Keyword(s):  
Map Kinase ◽  
Dual Map ◽  
Map Kinase Pathways

ERK and p38 MAP kinase are involved in arachidonic acid release induced by H2O2 and PDGF in mesangial cells

2002 ◽  
Vol 282 (3) ◽  
pp. F485-F491 ◽  
Author(s):  
Misako Hayama ◽  
Risa Inoue ◽  
Satoshi Akiba ◽  
Takashi Sato
Keyword(s):  
Arachidonic Acid ◽  
Map Kinase ◽  
Mesangial Cells ◽  
P38 Map Kinase ◽  
Arachidonic Acid Release ◽  
Cytosolic Phospholipase ◽  
Extracellular Signal ◽  
Mitogen Activated Protein ◽  
Acid Release ◽  
Map Kinase Pathways

Increased prostaglandin production is implicated in the pathogenesis of glomerular disease. With this consideration, we examined the combined effects of reactive oxygen species and platelet-derived growth factor (PDGF), which might initiate glomerular dysfunction, on arachidonic acid release and cytosolic phospholipase A2 (cPLA2) activation in rat mesangial cells. H2O2-induced release of arachidonic acid was enhanced by PDGF, which by itself had little effect on the release, and the enhancement was completely inhibited by a cPLA2 inhibitor. The phosphorylation of cPLA2, extracellular signal-regulated kinase (ERK), and p38 mitogen-activated protein (MAP) kinase was upregulated by H2O2 or PDGF alone and except for ERK was enhanced further by the two in combination. The release of arachidonic acid induced by PDGF together with H2O2 was inhibited partially by an inhibitor of ERK or p38 MAP kinase and completely when the two inhibitors were combined; the inhibitory pattern was similar to that for the phosphorylation of cPLA2. These results suggest that the ERK and p38 MAP kinase pathways are involved in the increase in cPLA2activation and arachidonic acid release induced by PDGF together with H2O2.

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