scholarly journals Using Drosophila Larval Imaginal Discs to Study Low-Dose Radiation-Induced Cell Cycle Arrest

2011 ◽  
pp. 93-103 ◽  
Author(s):  
Shian-Jang Yan ◽  
Willis X. Li
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Low Dose ◽  
Imaginal Discs ◽  
Low Dose Radiation ◽  
Cycle Arrest ◽  
Radiation Induced ◽  
Dose Radiation

The essential role of p21 in radiation-induced cell cycle arrest of vascular smooth muscle cell

2004 ◽  
Vol 37 (4) ◽  
pp. 871-880 ◽  
Author(s):  
Hyo-Soo Kim ◽  
Hyun-Jai Cho ◽  
Hyun-Ju Cho ◽  
Sun-Jung Park ◽  
Kyung-Woo Park ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Cell Cycle Arrest ◽  
Muscle Cell ◽  
Essential Role ◽  
Cycle Arrest ◽  
Radiation Induced

Low-dose radiation-induced acute pericarditis (AP) in breast cancer patient

2013 ◽  
Vol 18 ◽  
pp. S179-S180 ◽  
Author(s):  
I. Alastuey ◽  
A. Noé ◽  
C. Chiaramello ◽  
S. Montemuiño ◽  
J. Pardo
Keyword(s):  
Breast Cancer ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Low Dose ◽  
Low Dose Radiation ◽  
Acute Pericarditis ◽  
Radiation Induced ◽  
Dose Radiation

scholarly journals Low-Dose Radiation-Induced Senescent Stromal Fibroblasts Render Nearby Breast Cancer Cells Radioresistant

2009 ◽  
Vol 172 (3) ◽  
pp. 306-313 ◽  
Author(s):  
Kelvin K. C. Tsai ◽  
Jeremy Stuart ◽  
Yao-Yu Eric Chuang ◽  
John B. Little ◽  
Zhi-Min Yuan
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Low Dose ◽  
Low Dose Radiation ◽  
Stromal Fibroblasts ◽  
Radiation Induced ◽  
Dose Radiation

scholarly journals The Effect of Docetaxel (Taxotere®) on Human Gastric Cancer Cells Exhibiting Low-Dose Radiation Hypersensitivity

2008 ◽  
Vol 2 ◽  
pp. CMO.S463
Author(s):  
Elizabeth K. Balcer-Kubiczek ◽  
Mona Attarpour ◽  
Jian Z. Wang ◽  
William F. Regine
Keyword(s):  
Gastric Cancer ◽  
Cell Cycle ◽  
Cancer Cells ◽  
Time Course ◽  
Low Dose ◽  
Immunoblot Analysis ◽  
Human Gastric Cancer ◽  
Low Dose Radiation ◽  
Gastric Cancer Cells ◽  
Dose Radiation

Low-dose radiation hypersensitivity (HRS) describes a phenomenon of excessive sensitivity to X ray doses <0.5 Gy. Docetaxel is a taxane shown to arrest cells in the G2/M phase of the cell cycle. Some previous studies suggested that HRS might result from the abrogation of the early G2 checkpoint arrest. First we tested whether HRS occurs in gastric cancer—derived cells, and whether pre-treatment of cells with low docetaxel concentrations can enhance the magnitude of HRS in gastric cancer cells. The results demonstrated HRS at ~0.3 Gy and the synergy between 0.3 Gy and docetaxel (3 nM for 24 h), and the additivity of other drug/dose combinations. The synergistic effect was associated with a significant docetaxel-induced G2 accumulation. Next, we evaluated in time-course experiments ATM kinase activity and proteins associated with the induction and maintenance of the early G2 checkpoint. The results of multi-immunoblot analysis demonstrate that HRS does not correlate with the ATM-dependent early G2 checkpoint arrest. We speculate that G2 checkpoint adaptation, a phenomenon associated with a prolonged cell cycle arrest, might be involved in HRS. Our results also suggest a new approach for the improvement the effectiveness of docetaxel-based radiotherapy using low doses per fraction.

scholarly journals MRK, a Mixed Lineage Kinase-related Molecule That Plays a Role in γ-Radiation-induced Cell Cycle Arrest

2002 ◽  
Vol 277 (16) ◽  
pp. 13873-13882 ◽  
Author(s):  
Eleanore A. Gross ◽  
Marinella G. Callow ◽  
Linda Waldbaum ◽  
Suzanne Thomas ◽  
Rosamaria Ruggieri
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Γ Radiation ◽  
Related Molecule ◽  
Mixed Lineage Kinase ◽  
Cycle Arrest ◽  
Radiation Induced

scholarly journals Sodium Tanshinone IIA Sulfonate Prevents Radiation-Induced Toxicity in H9c2 Cardiomyocytes

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Wenjing Zhang ◽  
Yi Li ◽  
Rui Li ◽  
Yaya Wang ◽  
Mengwen Zhu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Antioxidant Activity ◽  
Cell Cycle Arrest ◽  
Tanshinone Iia ◽  
H9c2 Cells ◽  
X Ray ◽  
Cycle Arrest ◽  
H9c2 Cardiomyocytes ◽  
Radiation Induced

The present study was designed to elucidate the key parameters associated with X-ray radiation induced oxidative stress and the effects of STS on X-ray-induced toxicity in H9c2 cardiomyocytes. Cytotoxicity of STS and radiation was assessed by MTT. Antioxidant activity was evaluated by SOD and MDA. Apoptosis was measured by the flow cytometry, Hoechst 33258, clonogenic survival assay, and western blot. It was found that the cell viability of H9c2 cells exposed to X-ray radiation was significantly decreased in a dose-dependent manner and was associated with cell cycle arrest at the G0/G1 phase as well as apoptosis. STS treatment significantly reversed the morphological changes, attenuated radiation-induced apoptosis, and improved the antioxidant activity in the H9c2 cells. STS significantly increased the Bcl-2 and Bcl-2/Bax levels and decreased the Bax and caspase-3 levels, compared with the cells treated with radiation alone. STS treatment also resulted in a significant increase in p38-MAPK activation. STS could protect the cells from X-ray-induced cell cycle arrest, oxidative stress, and apoptosis. Therefore, we suggest the STS could be useful for the treatment of radiation-induced cardiovascular injury.

Low-dose radiation induced modification of ROS and apoptosis in thymocytes of whole body irradiated mice

2006 ◽  
Vol 2 (1/2) ◽  
pp. 111 ◽  
Author(s):  
B.N. Pandey ◽  
H.D. Sarma ◽  
D. Shukla ◽  
K.P. Mishra
Keyword(s):  
Low Dose ◽  
Whole Body ◽  
Low Dose Radiation ◽  
Radiation Induced ◽  
Dose Radiation

scholarly journals Low-dose radiation-induced apoptosis in human leukemia K562 cells through mitochondrial pathways

2014 ◽  
Vol 10 (3) ◽  
pp. 1569-1575 ◽  
Author(s):  
YONG XIN ◽  
HAI-BIN ZHANG ◽  
TIAN-YOU TANG ◽  
GUI-HONG LIU ◽  
JIAN-SHE WANG ◽  
...  
Keyword(s):  
Low Dose ◽  
K562 Cells ◽  
Human Leukemia ◽  
Low Dose Radiation ◽  
Radiation Induced ◽  
Induced Apoptosis ◽  
Dose Radiation ◽  
Human Leukemia K562 Cells

An Adoptive Transfer Method to Detect Low-Dose Radiation-Induced Bystander EffectsIn Vivo

2010 ◽  
Vol 173 (2) ◽  
pp. 125-137 ◽  
Author(s):  
Benjamin J. Blyth ◽  
Edouard I. Azzam ◽  
Roger W. Howell ◽  
Rebecca J. Ormsby ◽  
Alexander H. Staudacher ◽  
...  
Keyword(s):  
Adoptive Transfer ◽  
Low Dose ◽  
Low Dose Radiation ◽  
Radiation Induced ◽  
Transfer Method ◽  
Dose Radiation
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