Hollow Organ Engineering

Author(s):  
Anthony Atala
2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Michael DeLong ◽  
Mauricio Gil-Silva ◽  
Veronica Minsu Hong ◽  
Olivia Babyok ◽  
Benedict J. Kolber

Abstract Background The regulation and control of pressure stimuli is useful for many studies of pain and nociception especially those in the visceral pain field. In many in vivo experiments, distinct air and liquid stimuli at varying pressures are delivered to hollow organs such as the bladder, vagina, and colon. These stimuli are coupled with behavioral, molecular, or physiological read-outs of the response to the stimulus. Care must be taken to deliver precise timed stimuli during experimentation. For example, stimuli signals can be used online to precisely time-lock the stimulus with a physiological output. Such precision requires the development of specialized hardware to control the stimulus (e.g., air) while providing a precise read-out of pressure and stimulus signal markers. Methods In this study, we designed a timed pressure regulator [termed visceral pressure stimulator (VPS)] to control air flow, measure pressure (in mmHg), and send stimuli markers to online software. The device was built using a simple circuit and primarily off-the-shelf parts. A separate custom inline analog-to-digital pressure converter was used to validate the real pressure output of the VPS. Results Using commercial physiological software (Spike2, CED), we were able to measure mouse bladder pressure continuously during delivery of unique air stimulus trials in a mouse while simultaneously recording an electromyogram (EMG) of the overlying abdominal muscles. Conclusions This device will be useful for those who need to (1) deliver distinct pressure stimuli while (2) measuring the pressure in real-time and (3) monitoring stimulus on–off using physiological software.


2015 ◽  
Vol 2 (1) ◽  
pp. 19-29 ◽  
Author(s):  
XiangGuo Lv ◽  
JingXuan Yang ◽  
Chao Feng ◽  
Zhe Li ◽  
ShiYan Chen ◽  
...  

Author(s):  
Dr. G. Someswara Rao ◽  
◽  
Dr. B. Visweswara Rao ◽  

Introduction: Perforation is defined as an abnormal opening in a hollow organ or viscus. All overthe world, perforation peritonitis is the most prevalent surgical emergency tackled and treated by asurgical team. The etiology leading to peritonitis in tropical countries shows a different spectrumfrom its western world. The present study was conducted to highlight the spectrum of hollow viscusperforation peritonitis in terms of etiology, clinical presentations, site of perforation, surgicaltreatment, postoperative complications, and mortality encountered. Methods: The study was aprospective observational study conducted from March 2016 to March 2019 in the Department ofGeneral Surgery, Great Eastern Medical School and Hospital, Andhra Pradesh. A total of 320 patientswith perforation peritonitis were included in the study and underwent exploratory laparotomy.Results: Out of 320 patients, there were 276 males (86.25%) and 44 females (13.75%). Duodenalperforation was the most common type (34.38%), which was mainly due to Acid peptic diseasefollowed by Jejunal and Ileal perforations. Wound infection was the most common complication. Themortality rate was 8.44% (27 patients). Conclusion: Early diagnosis, resuscitation with fluids, andtimely surgical intervention are the most important factors deciding the fate of the patient withperforation peritonitis.


PEDIATRICS ◽  
1975 ◽  
Vol 55 (4) ◽  
pp. 562-562
Author(s):  
T. E. C.

Galen (A.D. 131-201), one of the greatest figures in medicine, was the principal authority in the medical schools of medieval and Renaissance Europe. Galen was so venerated by his contemporaries that many regarded him as a God and even formed a religious cult for his worship.1 His biologic views concerning women were not seriously challenged until the seventeenth century. In the Oeuvres de Galen(Paris, 1854-1856) one reads this about women: The female is more imperfect than the male. The first reason is that she is colder. if, among animals, the warmer ones are more active, it follows that the colder ones must be more imperfect . . . . Just as man is the most perfect of all animals, so also, within the human species, man is more perfect than woman. The cause of this superiority is the [male's] superabundance of warmth, heat being the primary instrument of nature . . . . The male's testicles are all the stronger because he is warmer. The sperm born there, on reaching the final degree of concoction, is the formative principle of the animal. From a single principle wisely imagined by the Creator— that whereby the female is less perfect than the male—follow all the conditions useful for the generation of animal: the impossibility for the female genitalia to emerge externally, the accumulation of a superfluity of useful nourishment, an imperfect sperm, a hollow organ capable of receiving perfect sperm. In the male, instead, everything is the reverse: an elongated member suitable for copulation and emitting sperm, and an abundance of this same thick warm sperm . . . .


Biomaterials ◽  
2020 ◽  
Vol 257 ◽  
pp. 120247
Author(s):  
Assal Daneshgar ◽  
Oliver Klein ◽  
Grit Nebrich ◽  
Marie Weinhart ◽  
Peter Tang ◽  
...  

2017 ◽  
Vol 52 ◽  
pp. 1-8 ◽  
Author(s):  
Luuk R. Versteegden ◽  
Kenny A. van Kampen ◽  
Heinz P. Janke ◽  
Dorien M. Tiemessen ◽  
Henk R. Hoogenkamp ◽  
...  

2015 ◽  
Vol 78 ◽  
pp. 51-57 ◽  
Author(s):  
Gerald S. Poplin ◽  
Timothy L. McMurry ◽  
Jason L. Forman ◽  
Thomas Hartka ◽  
Gwansik Park ◽  
...  

Author(s):  
T. Tsuchiya ◽  
T. Obata ◽  
H. Sengyoku ◽  
R. Doi ◽  
G. Hatachi ◽  
...  

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