Endoplasmic Reticulum Stress and Adipose Tissue Function

2014 ◽  
pp. 105-114
Author(s):  
Michael Pagliassotti ◽  
Gretchen Moran ◽  
Andrea Estrada ◽  
Michelle T. Foster
Keyword(s):  
Endoplasmic Reticulum ◽  
Adipose Tissue ◽  
Endoplasmic Reticulum Stress

scholarly journals Different Expression of Mitochondrial and Endoplasmic Reticulum Stress Genes in Epicardial Adipose Tissue Depends on Coronary Atherosclerosis

2021 ◽  
Vol 22 (9) ◽  
pp. 4538
Author(s):  
Helena Kratochvílová ◽  
Miloš Mráz ◽  
Barbora J. Kasperová ◽  
Daniel Hlaváček ◽  
Jakub Mahrík ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Endoplasmic Reticulum ◽  
Adipose Tissue ◽  
Cardiac Surgery ◽  
Endoplasmic Reticulum Stress ◽  
Er Stress ◽  
Mrna Expression ◽  
Coronary Atherosclerosis ◽  
Stress Genes ◽  
Valvular Surgery

The aim of our study was to analyze mitochondrial and endoplasmic reticulum (ER) gene expression profiles in subcutaneous (SAT) and epicardial (EAT) adipose tissue, skeletal muscle, and myocardium in patients with and without CAD undergoing elective cardiac surgery. Thirty-eight patients, 27 with (CAD group) and 11 without CAD (noCAD group), undergoing coronary artery bypass grafting and/or valvular surgery were included in the study. EAT, SAT, intercostal skeletal muscle, and right atrium tissue and blood samples were collected at the start and end of surgery; mRNA expression of selected mitochondrial and ER stress genes was assessed using qRT-PCR. The presence of CAD was associated with decreased mRNA expression of most of the investigated mitochondrial respiratory chain genes in EAT, while no such changes were seen in SAT or other tissues. In contrast, the expression of ER stress genes did not differ between the CAD and noCAD groups in almost any tissue. Cardiac surgery further augmented mitochondrial dysfunction in EAT. In our study, CAD was associated with decreased expression of mitochondrial, but not endoplasmic reticulum stress genes in EAT. These changes may contribute to the acceleration of coronary atherosclerosis.

scholarly journals Hyperhomocysteinemia Promotes Insulin Resistance by Inducing Endoplasmic Reticulum Stress in Adipose Tissue

2013 ◽  
Vol 288 (14) ◽  
pp. 9583-9592 ◽  
Author(s):  
Yang Li ◽  
Heng Zhang ◽  
Changtao Jiang ◽  
Mingjiang Xu ◽  
Yanli Pang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Endoplasmic Reticulum ◽  
Adipose Tissue ◽  
Endoplasmic Reticulum Stress

scholarly journals Increase in Endoplasmic Reticulum Stress-Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals

Diabetes ◽  
2008 ◽  
Vol 57 (9) ◽  
pp. 2438-2444 ◽  
Author(s):  
G. Boden ◽  
X. Duan ◽  
C. Homko ◽  
E. J. Molina ◽  
W. Song ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Adipose Tissue ◽  
Endoplasmic Reticulum Stress ◽  
Insulin Resistant ◽  
Related Proteins

scholarly journals Plant Bioactive Molecules Reduces Endoplasmic Reticulum Stress in Liver and Adipose Tissue of Obese Mice

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 482-482
Author(s):  
Ivan Torre-Villalvazo ◽  
Armando Tovar ◽  
Claudia Tovar-Palacio ◽  
Nimbe Torres ◽  
Erik Alejandro Torre ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Adipose Tissue ◽  
Endoplasmic Reticulum Stress ◽  
Er Stress ◽  
Low Dose ◽  
Control Diet ◽  
Bioactive Molecules ◽  
Obese Mice ◽  
Funding Sources ◽  
Stress Markers

Abstract Objectives To determine if diferent plant bioactive compounds can ammelirate endoplasmic reticulum stress markers in liver and adipose tissue of obese mice and mice administered with a low dose of tunicamicin. Methods C57BL6 mice were fed a control diet (7% fat) or a high-fat diet (21% fat) with and without genistein or resveratrol supplementation (0.1%) for 12 weeks. Pharmacologic ER stress was induced in mice fed the control diet by an ip injection of a low dose of tunicamycin and euthanized 8 or 24 h after tunicamycin administration. Adipose tissues and liver were harvested to determine the abundance of ER stress markers by western blot and real time PCR. Results Genistein and resveratrol reduced the abundance of phospho JNK and phospho PERK in liver and subcutaneous adipose tissue of obese mice and lean mice administered with tunicamycin. Both polyphenols increased the mRNA abundance of XBP1s and BiP and reduced that of CHOP in both organs. These changes in proten phosphorylation and gene expression were accompanied with reduced hepatic steatosis and adipocyte hypertrophy. Conclusions The supplementation with plant polyphenols such as genistein or resveratrol reduced ER stress markers in liver and adipose tissue of obese mice and lean mice administerd with tunicamycin. Funding Sources This work is supported by a grant from CONACYT, Mexico to ITV Grant No. A1-S-41,077.

scholarly journals Endoplasmic reticulum stress in adipose tissue augments lipolysis

2014 ◽  
Vol 19 (1) ◽  
pp. 82-91 ◽  
Author(s):  
Elena Bogdanovic ◽  
Nicole Kraus ◽  
David Patsouris ◽  
Li Diao ◽  
Vivian Wang ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Adipose Tissue ◽  
Endoplasmic Reticulum Stress
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