Design of a Label-Free Multiplexed Biosensing Platform Based on an Ultracompact Plasmonic Resonant Cavity

2019 ◽  
pp. 263-267
Author(s):  
Francesco Dell’Olio ◽  
Donato Conteduca ◽  
Maripina De Palo ◽  
Nicola Sasanelli ◽  
Caterina Ciminelli
Keyword(s):  
Resonant Cavity ◽  
Label Free ◽  
Multiplexed Biosensing

scholarly journals Resonant Cavity Imaging: A Means Toward High-Throughput Label-Free Protein Detection

2008 ◽  
Vol 14 (1) ◽  
pp. 131-139 ◽  
Author(s):  
David A. Bergstein ◽  
Charles DeLisi ◽  
Michael F. Ruane ◽  
M. Selim Unlu ◽  
Emre Ozkumur ◽  
...  
Keyword(s):  
High Throughput ◽  
Resonant Cavity ◽  
Protein Detection ◽  
Label Free ◽  
Free Protein

scholarly journals Label-Free, Single Molecule Resonant Cavity Detection: A Double-Blind Experimental Study

Sensors ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. 6324-6341 ◽  
Author(s):  
Maria Chistiakova ◽  
Ce Shi ◽  
Andrea Armani
Keyword(s):  
Experimental Study ◽  
Single Molecule ◽  
Resonant Cavity ◽  
Label Free ◽  
Double Blind ◽  
Cavity Detection

Label-free, mass-sensitive single-molecule imaging using interferometric scattering microscopy

2020 ◽  
Author(s):  
Nikolas Hundt
Keyword(s):  
Single Molecule ◽  
Cellular Systems ◽  
Single Molecule Imaging ◽  
Label Free ◽  
Measurement Sensitivity ◽  
Mass Distributions ◽  
Quantitative Measurements ◽  
Contrast Mechanism ◽  
Cellular Components ◽  
Scattering Signal

Abstract Single-molecule imaging has mostly been restricted to the use of fluorescence labelling as a contrast mechanism due to its superior ability to visualise molecules of interest on top of an overwhelming background of other molecules. Recently, interferometric scattering (iSCAT) microscopy has demonstrated the detection and imaging of single biomolecules based on light scattering without the need for fluorescent labels. Significant improvements in measurement sensitivity combined with a dependence of scattering signal on object size have led to the development of mass photometry, a technique that measures the mass of individual molecules and thereby determines mass distributions of biomolecule samples in solution. The experimental simplicity of mass photometry makes it a powerful tool to analyse biomolecular equilibria quantitatively with low sample consumption within minutes. When used for label-free imaging of reconstituted or cellular systems, the strict size-dependence of the iSCAT signal enables quantitative measurements of processes at size scales reaching from single-molecule observations during complex assembly up to mesoscopic dynamics of cellular components and extracellular protrusions. In this review, I would like to introduce the principles of this emerging imaging technology and discuss examples that show how mass-sensitive iSCAT can be used as a strong complement to other routine techniques in biochemistry.

Techniques for assessing the performance of circuit materials at microwave and millimetre-wave frequencies

2003 ◽  
Vol 783 ◽  
Author(s):  
Charles E Free
Keyword(s):  
Loss Tangent ◽  
Good Accuracy ◽  
Low Cost ◽  
Resonant Cavity ◽  
New Technique ◽  
Millimetre Wave ◽  
A New Technique

This paper discusses the techniques that are available for characterising circuit materials at microwave and millimetre wave frequencies. In particular, the paper focuses on a new technique for measuring the loss tangent of substrates at mm-wave frequencies using a circular resonant cavity. The benefits of the new technique are that it is simple, low cost, capable of good accuracy and has the potential to work at high mm-wave frequencies.

A microfluidic device with integrated impedance detection for λ-DNA

2003 ◽  
Vol 773 ◽  
Author(s):  
Myung-Il Park ◽  
Jonging Hong ◽  
Dae Sung Yoon ◽  
Chong-Ook Park ◽  
Geunbae Im
Keyword(s):  
Microfluidic Device ◽  
Electrochemical Impedance ◽  
Direct Detection ◽  
Full Potential ◽  
Label Free ◽  
Buffer Solution ◽  
Detection Systems ◽  
Significant Difference ◽  
Detection Of Biomolecules ◽  
Impedance Magnitude

AbstractThe large optical detection systems that are typically utilized at present may not be able to reach their full potential as portable analysis tools. Accurate, early, and fast diagnosis for many diseases requires the direct detection of biomolecules such as DNA, proteins, and cells. In this research, a glass microchip with integrated microelectrodes has been fabricated, and the performance of electrochemical impedance detection was investigated for the biomolecules. We have used label-free λ-DNA as a sample biomolecule. By changing the distance between microelectrodes, the significant difference between DW and the TE buffer solution is obtained from the impedance-frequency measurements. In addition, the comparison for the impedance magnitude of DW, the TE buffer, and λ-DNA at the same distance was analyzed.

METHODS FOR OBTAINING MULTIFREQUENCY LASING IN RESONANT CAVITY OF THE THZ LASER

2016 ◽  
Vol 75 (4) ◽  
pp. 355-361
Author(s):  
V. P. Radionov ◽  
P. K. Nesterov ◽  
V. K. Kiseliov
Keyword(s):  
Resonant Cavity

Usefulness of Foundry Tooling Materials in Microwave Heating Process

2013 ◽  
Vol 58 (3) ◽  
pp. 919-922 ◽  
Author(s):  
K. Granat ◽  
B. Opyd ◽  
D. Nowak ◽  
M. Stachowicz ◽  
G. Jaworski
Keyword(s):  
Electromagnetic Field ◽  
Microwave Heating ◽  
Loss Factor ◽  
Perturbation Technique ◽  
Resonant Cavity ◽  
Precise Determination ◽  
Heating Process ◽  
Basic Criterion ◽  
Measurement Results ◽  
Heating Technology

Abstract The paper describes preliminary examinations on establishing usefulness criteria of foundry tooling materials in the microwave heating technology. Presented are measurement results of permittivity and loss tangent that determine behaviour of the materials in electromagnetic field. The measurements were carried-out in a waveguide resonant cavity that permits precise determination the above-mentioned parameters by perturbation technique. Examined were five different materials designed for use in foundry tooling. Determined was the loss factor that permits evaluating usefulness of materials in microwave heating technology. It was demonstrated that the selected plastics meet the basic criterion that is transparency for electromagnetic radiation.

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