Bioactive Metabolites Isolated from Microorganisms for Healthcare: Types and Delivery Routes

2019 ◽  
pp. 75-97 ◽  
Author(s):  
Debashish Mohanta ◽  
S. Maneesha ◽  
Rajesh Ghangal ◽  
Manu Solanki ◽  
Soma Patnaik
Keyword(s):  
Bioactive Metabolites ◽  
Delivery Routes

Targeted isolation of induced and bioactive metabolites from fungal co-cultures

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
N Bohni ◽  
O Schumpp ◽  
S Schnee ◽  
S Bertrand ◽  
K Gindro ◽  
...  
Keyword(s):  
Bioactive Metabolites

Investigation into the bioactive metabolites of deep sea fungi

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
CL Bromley ◽  
RM Young ◽  
S Jackson ◽  
T Sutton ◽  
A Dobson ◽  
...  
Keyword(s):  
Deep Sea ◽  
Bioactive Metabolites

Metabolomics of Healthy Berry Fruits

2019 ◽  
Vol 25 (37) ◽  
pp. 4888-4902 ◽  
Author(s):  
Gilda D'Urso ◽  
Sonia Piacente ◽  
Cosimo Pizza ◽  
Paola Montoro
Keyword(s):  
Biological Activities ◽  
Biologically Active ◽  
In Vivo Studies ◽  
Bioactive Metabolites ◽  
Active Metabolites ◽  
Positive Effects ◽  
Cell Functions ◽  
Berry Fruits

The consumption of berry-type fruits has become very popular in recent years because of their positive effects on human health. Berries are in fact widely known for their health-promoting benefits, including prevention of chronic disease, cardiovascular disease and cancer. Berries are a rich source of bioactive metabolites, such as vitamins, minerals, and phenolic compounds, mainly anthocyanins. Numerous in vitro and in vivo studies recognized the health effects of berries and their function as bioactive modulators of various cell functions associated with oxidative stress. Plants have one of the largest metabolome databases, with over 1200 papers on plant metabolomics published only in the last decade. Mass spectrometry (MS) and NMR (Nuclear Magnetic Resonance) are the most important analytical technologies on which the emerging ''omics'' approaches are based. They may provide detection and quantization of thousands of biologically active metabolites from a tissue, working in a ''global'' or ''targeted'' manner, down to ultra-trace levels. In the present review, we highlighted the use of MS and NMR-based strategies and Multivariate Data Analysis for the valorization of berries known for their biological activities, important as food and often used in the preparation of nutraceutical formulations.

Improved Production of Two Anti-Candida Lipopeptide Homologues Co- Produced by the Wild-Type Bacillus subtilis RLID 12.1 under Optimized Conditions

2020 ◽  
Vol 21 (5) ◽  
pp. 438-450
Author(s):  
Ramya Ramchandran ◽  
Swetha Ramesh ◽  
Anviksha A ◽  
RamLal Thakur ◽  
Arunaloke Chakrabarti ◽  
...  
Keyword(s):  
Bacillus Subtilis ◽  
Pathogenic Fungi ◽  
Fold Increase ◽  
Production Yield ◽  
Yield Enhancement ◽  
Bioactive Metabolites ◽  
Candida Auris ◽  
Media Formulation ◽  
Static Conditions

Background:: Antifungal cyclic lipopeptides, bioactive metabolites produced by many species of the genus Bacillus, are promising alternatives to synthetic fungicides and antibiotics for the biocontrol of human pathogenic fungi. In a previous study, the co- production of five antifungal lipopeptides homologues (designated as AF1, AF2, AF3, AF4 and AF5) by the producer strain Bacillus subtilis RLID 12.1 using unoptimized medium was reported; though the two homologues AF3 and AF5 differed by 14 Da and in fatty acid chain length were found effective in antifungal action, the production/ yield rate of these two lipopeptides determined by High-Performance Liquid Chromatography was less in the unoptimized media. Methods:: In this study, the production/yield enhancement of the two compounds AF3 and AF5 was specifically targeted. Following the statistical optimization (Plackett-Burman and Box-Behnken designs) of media formulation, temperature and growth conditions, the production of AF3 and AF5 was improved by about 25.8- and 7.4-folds, respectively under static conditions. Results:: To boost the production of these two homologous lipopeptides in the optimized media, heat-inactivated Candida albicans cells were used as a supplement resulting in 34- and 14-fold increase of AF3 and AF5, respectively. Four clinical Candida auris isolates had AF3 and AF5 MICs (100 % inhibition) ranging between 4 and 16 μg/ml indicating the lipopeptide’s clinical potential. To determine the in vitro pharmacodynamic potential of AF3 and AF5, time-kill assays were conducted which showed that AF3 (at 4X and 8X concentrations) at 48h exhibited mean log reductions of 2.31 and 3.14 CFU/ml of C. albicans SC 5314, respectively whereas AF5 at 8X concentration showed a mean log reduction of 2.14 CFU/ml. Conclusion:: With the increasing threat of multidrug-resistant yeasts and fungi, these antifungal lipopeptides produced by optimized method promise to aid in the development of novel antifungal that targets disease-causing fungi with improved efficacy.

Recent progress in marine mollusks from the South China Sea: chemical and ecological studies

2020 ◽  
Vol 17 ◽  
Author(s):  
Song-Wei Li ◽  
Yue-Wei Guo
Keyword(s):  
South China Sea ◽  
South China ◽  
Biological Activities ◽  
The South China Sea ◽  
Bioactive Metabolites ◽  
Research Subject ◽  
Ecological Studies ◽  
The South ◽  
China Sea ◽  
Marine Mollusks

: Marine mollusks are a prolific source of secondary metabolites with complex/diverse structures and various aspects of biological activities. For above mentioned reason, these animals have been being extensively explored and became the hotspot of research subject in the recent years. It is well documented that mollusks can escape from predation by utilizing bioactive metabolites as defensive chemicals. In the last decade, the possible diet relationship between the South China Sea mollusks and their related potential prey organisms, including sponges, corals, algae, etc. have been systematically investigated. A series of interesting results have been obtained concerning the chemistry, chemoecology and pharmacological profiles of the studied marine organisms. The present review focuses on recent development dealing with chemistry, chemoecology, and bioactivity of the South China Sea mollusks and their dietary organisms.

Analytical Methods of Bioactive Metabolites Produced by Plants and Microorganisms

2005 ◽  
Vol 1 (3) ◽  
pp. 329-348
Author(s):  
Antonio Evidente ◽  
Anna Andolfi ◽  
Mohamed Abouzeid
Keyword(s):  
Analytical Methods ◽  
Bioactive Metabolites
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