Antigenotoxic Effect of Some Lichen Metabolites

2019 ◽  
pp. 175-197
Author(s):  
Hülya Sivas
Keyword(s):  
Lichen Metabolites ◽  
Antigenotoxic Effect

Antigenotoxic effect of mangosteen juice on the DNA damage induced by daunorubicin in mouse

2016 ◽  
Vol 258 ◽  
pp. S160 ◽  
Author(s):  
D. Castilla Burguete ◽  
R. Xavier Castro ◽  
G. Pardo Rosich ◽  
A. Vergara Castañeda ◽  
L. Martino Roaro
Keyword(s):  
Dna Damage ◽  
Antigenotoxic Effect

Mass spectrometry as a versatile ancillary technique for the rapid in situ identification of lichen metabolites directly from TLC plates

2017 ◽  
Vol 49 (5) ◽  
pp. 507-520 ◽  
Author(s):  
Pierre LE POGAM ◽  
Aline PILLOT ◽  
Françoise LOHEZIC-LE DEVEHAT ◽  
Anne-Cécile LE LAMER ◽  
Béatrice LEGOUIN ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Accurate Identification ◽  
Chemical Profiling ◽  
Analytical Strategies ◽  
Tlc Plates ◽  
Lichen Metabolites ◽  
Acetone Extracts ◽  
Layer Chromatography ◽  
Structural Classes

AbstractThin-layer chromatography (TLC) still enjoys widespread popularity among lichenologists as one of the fastest and simplest analytical strategies, today remaining the primary method of assessing the secondary product content of lichens. The pitfalls associated with this approach are well known as TLC leads to characterizing compounds by comparison with standards rather than properly identifying them, which might lead to erroneous assignments, accounting for the long-held interest in hyphenating TLC with dedicated identification tools. As such, commercially available TLC/Mass Spectrometry (MS) interfaces can be easily connected to any brand of mass spectrometer without adjustments. The spots of interest are extracted from the TLC plate to retrieve mass spectrometric signals within one minute, thereby ensuring accurate identification of the chromatographed substances. The results of this hyphenated strategy for lichens are presented here by 1) describing the TLC migration and direct MS analysis of single lichen metabolites of various structural classes, 2) highlighting it through the chemical profiling of crude acetone extracts of a set of lichens of known chemical composition, and finally 3) applying it to a lichen of unknown profile, Usnea trachycarpa.

Beneficial Effects of Liposomal Formulations of Lichen Substances: A Review

2021 ◽  
Vol 18 ◽  
Author(s):  
Vinay Bharadwaj Tatipamula ◽  
Ha Thi Nguyen ◽  
Biljana Kukavica
Keyword(s):  
Substantial Improvement ◽  
Traditional Medicines ◽  
Beneficial Effects ◽  
Liposomal Formulations ◽  
Lichen Substances ◽  
Potential Applications ◽  
Lichen Metabolites ◽  
North And South America ◽  
North And South ◽  
Low Solubility

: Lichens are commonly used as essential traditional medicines to treat various conditions, including skin disorders, wounds, digestive, respiratory, obstetric, and gynecological problems in many cultures in Africa, Asia, Europe, Haitian, Oceania, and North and South America. Lichens have been deeply investigated for their phytochemical properties, and to date, numerous compounds (also known as substances) have been successfully isolated from the extracts. However, the low solubility and bioavailability of pure lichen substances have been widely recognized as the significant issues hindering their biological applications. Recently, several groups have investigated the properties and the potential applications of lichen metabolites-based liposomal formulations and revealed a substantial improvement in their solubility, bioactivity, and toxicity in the animal. Thus, in this topical review, we aimed to provide an overview of liposomal structures, the efficacy of liposomal formulations, as well as their beneficial effects as compared to the free compounds themselves.

The structure of alectoronic acid and related lichen metabolites

1974 ◽  
Vol 27 (11) ◽  
pp. 2403 ◽  
Author(s):  
JA Elix ◽  
BA Ferguson ◽  
MV Sargent
Keyword(s):  
Spectroscopic Evidence ◽  
Lactone Form ◽  
Lichen Metabolites

Spectroscopic evidence is presented to show that the lichen depsidone alectoronic acid is a tautomeric compound which exists predominantly in a novel, six-membered, pseudo-acid (hydroxy lactone) form. The existence of this pseudo-acid tautomer was confirmed chemically by esterification with acidic methanol, whereupon the corresponding pseudo-ester was produced. P.m.r. spectroscopy indicated that the related depsidone, α-collatolic acid, and the lichen depside, microphyllinic acid, exhibit analogous ring-chain tautomerism.

Antigenotoxic Effect of Genistein and Gingerol on Genotoxicity Induced by Norethandrolone and Oxandrolone in Cultured Human Lymphocytes

2008 ◽  
Vol 4 (3) ◽  
pp. 177-183 ◽  
Author(s):  
Tanveer Beg ◽  
Yasir Hasan Sidd ◽  
Gulshan Ara ◽  
Jyoti Gupta ◽  
Mohammad Afzal
Keyword(s):  
Human Lymphocytes ◽  
Antigenotoxic Effect

scholarly journals Antioxidant Capacity and Antigenotoxic Effect of Hibiscus sabdariffa L. Extracts Obtained with Ultrasound-Assisted Extraction Process

2020 ◽  
Vol 10 (2) ◽  
pp. 560
Author(s):  
Gregorio Iván Peredo Pozos ◽  
Mario Alberto Ruiz-López ◽  
Juan Francisco Zamora Nátera ◽  
Carlos Álvarez Moya ◽  
Lucia Barrientos Ramírez ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Human Lymphocytes ◽  
Dry Weight ◽  
Extraction Process ◽  
Hibiscus Sabdariffa ◽  
Ultrasound Assisted Extraction ◽  
Solid Ratio ◽  
Assisted Extraction ◽  
Ultrasound Assisted ◽  
Antigenotoxic Effect

Hibiscus sabdariffa (Roselle) is in high demand worldwide due to its beneficial health properties owing to the polyphenols content, mainly in the flower calyx. The objective of this study was to find the best conditions (time and liquid: solid ratio) to extract polyphenols from Roselle using Ultrasound-Assisted Extraction (UAE) (40 kHz, 180 W), with ethanol how solvent; as well as determine the yield of phenols, anthocyanin, flavonoids, tannins, antioxidant activity (DPPH) and antigenotoxic effect (comet assay). A traditional solid-liquid extraction was applied as a reference. Extraction times of 40 and 60 min resulted in the highest polyphenols (13.019 mg GAE/g dry weight (dw)), flavonoids (4.981 CE/g dw), anthocyanins (1.855 mg Cya3GE/g dw), and tannins (0.745 CE/g dw) recoveries and an antioxidant activity (DPPH) of 74.58%. Extracts from white calyces contained similar amounts of phenols and flavonoids, but very little condensed tannins (0.049 CE/g dw) and practically no anthocyanins. Extracts from red and white calyces, showed antigenotoxic activity and repaired capacity of damage caused by mutagens in human lymphocytes.

Photohemolytic activity of lichen metabolites

1993 ◽  
Vol 21 (1) ◽  
pp. 37-40 ◽  
Author(s):  
M.E. Hidalgo ◽  
E. Fernández ◽  
W. Quilhot ◽  
E.A. Lissi
Keyword(s):  
Lichen Metabolites

scholarly journals Antioxidant and antigenotoxic effect of dairy products supplemented with red ginseng extract

2018 ◽  
Vol 101 (10) ◽  
pp. 8702-8710 ◽  
Author(s):  
Hanyeong Park ◽  
Minhee Lee ◽  
Kee-Tae Kim ◽  
Eunju Park ◽  
Hyun-Dong Paik
Keyword(s):  
Dairy Products ◽  
Red Ginseng ◽  
Ginseng Extract ◽  
Antigenotoxic Effect
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