scholarly journals Trained Innate Immunity and Its Implications for Mucosal Immunity and Inflammation

2019 ◽  
pp. 11-26 ◽  
Author(s):  
George Hajishengallis ◽  
Xiaofei Li ◽  
Ioannis Mitroulis ◽  
Triantafyllos Chavakis
Keyword(s):  
Innate Immunity ◽  
Mucosal Immunity

scholarly journals The Origin of Mucosal Immunity: Lessons from the Holobiont Hydra

mBio ◽  
2016 ◽  
Vol 7 (6) ◽  
Author(s):  
Katja Schröder ◽  
Thomas C. G. Bosch
Keyword(s):  
Innate Immunity ◽  
Mucosal Immunity ◽  
Epithelial Tissue ◽  
Animal Cells ◽  
Mucosal Surfaces ◽  
Pathogenic Microbes ◽  
Upper Respiratory ◽  
New Perspective ◽  
First Time ◽  
The Relationship

ABSTRACT Historically, mucosal immunity—i.e., the portion of the immune system that protects an organism’s various mucous membranes from invasion by potentially pathogenic microbes—has been studied in single-cell epithelia in the gastrointestinal and upper respiratory tracts of vertebrates. Phylogenetically, mucosal surfaces appeared for the first time about 560 million years ago in members of the phylum Cnidaria. There are remarkable similarities and shared functions of mucosal immunity in vertebrates and innate immunity in cnidarians, such as Hydra species. Here, we propose a common origin for both systems and review observations that indicate that the ultimately simple holobiont Hydra provides both a new perspective on the relationship between bacteria and animal cells and a new prism for viewing the emergence and evolution of epithelial tissue-based innate immunity. In addition, recent breakthroughs in our understanding of immune responses in Hydra polyps reared under defined short-term gnotobiotic conditions open up the potential of Hydra as an animal research model for the study of common mucosal disorders.

scholarly journals Innate immunity in HIV-1 infection: epithelial and non-specific host factors of mucosal immunity- a workshop report

Oral Diseases ◽  
2016 ◽  
Vol 22 ◽  
pp. 171-180 ◽  
Author(s):  
W Nittayananta ◽  
A Weinberg ◽  
D Malamud ◽  
D Moyes ◽  
J Webster-Cyriaque ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Mucosal Immunity ◽  
Host Factors ◽  
Workshop Report ◽  
Specific Host ◽  
Hiv 1

scholarly journals Tissue Distribution of Surfactant Proteins A and D in the Mouse

2002 ◽  
Vol 50 (7) ◽  
pp. 993-996 ◽  
Author(s):  
Jennifer Akiyama ◽  
Ari Hoffman ◽  
Cynthia Brown ◽  
Lennell Allen ◽  
Jess Edmondson ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Tissue Distribution ◽  
Lacrimal Gland ◽  
Mucosal Immunity ◽  
The Body ◽  
Surfactant Proteins ◽  
Limited Distribution

Surfactant proteins A and D, collagen-like lectins (collectins), were first isolated from the lung. In the lung, SP-A and SP-D have roles in surfactant homeostasis and innate immunity. In this study we show that SP-A and SP-D mRNA can be detected in a significant number of non-pulmonary tissues but the proteins have a more limited distribution. SP-D protein was detected in lung, uterus, ovary, and lacrimal gland, whereas SP-A protein was detected only in the lung. The results suggest that SP-D participates in mucosal immunity throughout the body.

DNA Makes RNA Makes Innate Immunity

2009 ◽  
Vol 138 (33) ◽  
pp. 428-430
Author(s):  
Luke A.J. O'Neill
Keyword(s):  
Innate Immunity
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