Network Medicine and Systems Biology Considerations to Understand Sex Differences in Lung Disease

2021 ◽  
pp. 345-363
Author(s):  
Dawn L. DeMeo
Keyword(s):  
Sex Differences ◽  
Systems Biology ◽  
Lung Disease ◽  
Network Medicine

scholarly journals Sex differences in non-communicable disease prevalence in China: a cross-sectional analysis of the China Health and Retirement Longitudinal Study in 2011

BMJ Open ◽  
2017 ◽  
Vol 7 (12) ◽  
pp. e017450 ◽  
Author(s):  
Yan Liu ◽  
Guofeng Liu ◽  
Hongjiang Wu ◽  
Weiyan Jian ◽  
Sarah H Wild ◽  
...  
Keyword(s):  
Sex Differences ◽  
Heart Disease ◽  
Longitudinal Study ◽  
Lung Disease ◽  
Chronic Lung Disease ◽  
Communicable Disease ◽  
Age Groups ◽  
Sociodemographic Factors ◽  
Age Group ◽  
Cross Sectional

ObjectivesTo describe the sex differences in the prevalence of non-communicable diseases (NCDs) in adults aged 45 years or older in China.DesignCross-sectional study.SettingNationally representative sample of the Chinese population 2011.Participants8401 men and 8928 women over 45 years of age who participated in the first wave of the China Health and Retirement Longitudinal Study (CHARLS).Outcome measuresSelf-reported data on overall health and diagnosis of hypertension, dyslipidaemia, diabetes, heart disease, stroke, chronic lung disease, cancer or arthritis. Sex differences in NCDs were described using logistic regression to generate odds ratios (OR) with adjustment for sociodemographic factors and health-related behaviours. All analyses were stratified by age group for 45–64-year-old and ≥65-year-old participants.ResultsIn both age groups, men reported better overall health than women. The crude prevalence of heart disease, cancer and arthritis was higher while that of stroke and chronic lung disease was lower in women than in men. After adjustment, ORs (95% CI) for the 45–64 and ≥65 year age groups were 0.70 (0.58 to 0.84) and 0.66 (0.54 to 0.80), respectively, for arthritis for men compared with women. In contrast, ORs were 1.66 (1.09 to 2.52) and 2.12 (1.36 to 3.30) for stroke and 1.51 (1.21 to 1.89) and 1.43 (1.09 to 1.88) for chronic lung disease for men compared with women. ORs for heart disease (0.65 (0.52 to 0.80)) were lower in men than in women only in the 45–64 year age group.ConclusionsOdds of arthritis were lower while those of stroke and chronic lung disease were higher in men than in women in both age groups. However, odds of heart disease were lower in men than in women, but only in the group of individuals aged 45–64 years.

scholarly journals Women and Lung Disease. Sex Differences and Global Health Disparities

2015 ◽  
Vol 192 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Kent E. Pinkerton ◽  
Mary Harbaugh ◽  
MeiLan K. Han ◽  
Claude Jourdan Le Saux ◽  
Laura S. Van Winkle ◽  
...  
Keyword(s):  
Sex Differences ◽  
Health Disparities ◽  
Global Health ◽  
Lung Disease

scholarly journals Systems biology asks new questions about sex differences

2009 ◽  
Vol 20 (10) ◽  
pp. 471-476 ◽  
Author(s):  
Arthur P. Arnold ◽  
Atila van Nas ◽  
Aldons J. Lusis
Keyword(s):  
Sex Differences ◽  
Systems Biology

scholarly journals Sex dependent gene activity in the human body

2020 ◽  
Author(s):  
Robin J.G. Hartman ◽  
Michal Mokry ◽  
Gerard Pasterkamp ◽  
Hester M. den Ruijter
Keyword(s):  
Sex Differences ◽  
Systems Biology ◽  
Human Body ◽  
Epithelial To Mesenchymal Transition ◽  
Tissue Expression ◽  
Gene Activity ◽  
Whole Body ◽  
Sequencing Data ◽  
Disease Etiology ◽  
Mesenchymal Transition

AbstractMany pathophysiological mechanisms in human health and disease are dependent on sex. Systems biology approaches are successfully used to decipher human disease etiology, yet the effect of sex on gene network biology is mostly unknown. To address this, we used RNA-sequencing data of over 700 individuals spanning 24 tissues from the Genotype-Tissue Expression project to generate a whole-body gene activity map and quantified the sex differences per tissue. We found that of the 13,787 genes analyzed in 24 tissues, 20.1% of the gene activity is influenced by sex. For example, skeletal muscle was predominantly enriched with genes more active in males, whereas thyroid primarily contained genes more active in females. This was accompanied by consistent sex differences in pathway activity, including hypoxia, epithelial-to-mesenchymal transition, and inflammation over the human body. Furthermore, multi-organ analyses revealed consistent sex-dependent gene activity over numerous tissues which was accompanied by enrichment of transcription factor binding motifs in the promoters of these genes. Finally, we show that many sex-biased genes are known druggable targets. This emphasizes sex as a biological variable and the need to incorporate sex in systems biology studies.

scholarly journals A Systems Biology Approach to Investigating Sex Differences in Cardiac Hypertrophy

2017 ◽  
Vol 6 (8) ◽  
Author(s):  
Josephine Harrington ◽  
Natasha Fillmore ◽  
Shouguo Gao ◽  
Yanqin Yang ◽  
Xue Zhang ◽  
...  
Keyword(s):  
Sex Differences ◽  
Systems Biology ◽  
Cardiac Hypertrophy

Complex systems in pulmonary medicine: a systems biology approach to lung disease

2011 ◽  
Vol 110 (6) ◽  
pp. 1716-1722 ◽  
Author(s):  
David A. Kaminsky ◽  
Charles G. Irvin ◽  
Peter J. Sterk
Keyword(s):  
Systems Biology ◽  
Lung Disease ◽  
Clinical Medicine ◽  
Molecular Genetic ◽  
Whole Body ◽  
Pulmonary Medicine ◽  
Pulmonary Physiology ◽  
The Many ◽  
And Function ◽  
Work Done

The lung is a highly complex organ that can only be understood by integrating the many aspects of its structure and function into a comprehensive view. Such a view is provided by a systems biology approach, whereby the many layers of complexity, from the molecular genetic, to the cellular, to the tissue, to the whole organ, and finally to the whole body, are synthesized into a working model of understanding. The systems biology approach therefore relies on the expertise of many disciplines, including genomics, proteomics, metabolomics, physiomics, and, ultimately, clinical medicine. The overall structure and functioning of the lung cannot be predicted from studying any one of these systems in isolation, and so this approach highlights the importance of emergence as the fundamental feature of systems biology. In this paper, we will provide an overview of a systems biology approach to lung disease by briefly reviewing the advances made at many of these levels, with special emphasis on recent work done in the realm of pulmonary physiology and the analysis of clinical phenotypes.

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