Evidence-biased Antidepressant Prescription

2022 ◽  
Author(s):  
Michael P. Hengartner
Keyword(s):  
Antidepressant Prescription

Association of Maternal Antidepressant Prescription During Pregnancy With Standardized Test Scores of Danish School-aged Children

JAMA ◽  
2021 ◽  
Vol 326 (17) ◽  
pp. 1725
Author(s):  
Jakob Christensen ◽  
Betina B. Trabjerg ◽  
Yuelian Sun ◽  
Julie Werenberg Dreier
Keyword(s):  
Test Scores ◽  
Standardized Test ◽  
Standardized Test Scores ◽  
School Aged Children ◽  
Antidepressant Prescription ◽  
Danish School

The Relationship Between Antidepressant Prescription Rates and Rate of Early Adolescent Suicide

2006 ◽  
Vol 163 (11) ◽  
pp. 1898-1904 ◽  
Author(s):  
Robert D. Gibbons ◽  
Kwan Hur ◽  
Dulal K. Bhaumik ◽  
J. John Mann
Keyword(s):  
Adolescent Suicide ◽  
Early Adolescent ◽  
Antidepressant Prescription ◽  
Prescription Rates ◽  
The Relationship

scholarly journals Pattern of antidepressant use and duration of depression-related absence from work

10.1192/03-91 ◽  
2003 ◽  
Vol 183 (6) ◽  
pp. 507-513 ◽  
Author(s):  
Carolyn S. Dewa ◽  
Jeffrey S. Hoch ◽  
Elizabeth Lin ◽  
Michael Paterson ◽  
Paula Goering
Keyword(s):  
Observational Study ◽  
Return To Work ◽  
Disability Benefits ◽  
First Line ◽  
Short Term ◽  
Insurance Sector ◽  
Antidepressant Prescription ◽  
Antidepressant Use ◽  
Absence From Work ◽  
The Relationship

BackgroundFew studies have examined the relationship between antidepressant prescription and receipt of depression-related disability benefits.AimsTo address two questions: first, is prescription of antidepressants in accordance with published clinical guides associated with better disability outcomes, and second, what is the relationship between guideline-concordant antidepressant prescription and length of disability?MethodAn observational study was conducted using administrative data from three major Canadian financial and insurance sector companies. Short-term disability and prescription drug claims records for 1996–1998 were linked for workers receiving depression-related short-term disability benefits during that time.ResultsRecommended first-line agents and recommended doses were significantly associated with return to work (χ2=6.64, P < 0.036). In addition, among those who returned to work, early intervention was significantly associated with a shortened disability episode (β=-24.1; 95% CI-34.4 to −13.8).ConclusionsDepression-related workplace disability is a problem for which there is no simple solution. These results provide an additional piece to the puzzle of helping workers disabled by depression to return to work.

Antidepressant prescription in acute myocardial infarction is associated with increased mortality 1 year after discharge

2019 ◽  
Vol 61 ◽  
pp. 75-80 ◽  
Author(s):  
Nadia Fehr ◽  
Fabienne Witassek ◽  
Dragana Radovanovic ◽  
Paul Erne ◽  
Milo Puhan ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Antidepressant Prescription

scholarly journals Effect of increased antidepressant prescribing on suicide rate in Northern Ireland

1999 ◽  
Vol 23 (8) ◽  
pp. 484-486 ◽  
Author(s):  
Christopher B. Kelly ◽  
Thérèse Rafferty
Keyword(s):  
Northern Ireland ◽  
Suicide Rate ◽  
Antidepressant Treatment ◽  
Depressive Illness ◽  
Clinical Implications ◽  
Defined Daily Dose ◽  
Central Unit ◽  
Antidepressant Prescription ◽  
Daily Dose ◽  
Antidepressant Use

Aims and methodTo investigate whether changes in antidepressant prescribing have been associated with alteration in suicide rate for the period 1989–1996 in Northern Ireland. Data for antidepressant prescribing were obtained from a central unit, for Northern Ireland, using the defined daily dose system for each of the above years. The number of recorded cases of suicide and undetermined death were also obtained for this period, from Northern Ireland coroners.ResultsThere was no evidence of an association between suicide rate and antidepressant prescription (r2=0.019, F test=0.115, P=0.74), despite antidepressant use more than tripling over the study period.Clinical implicationsEven substantial increases in detection and treatment of depressive Illness may not impinge on suicide rate. It Is also possible that suicide rate may be a very poor marker of the benefits of antidepressant treatment.

An Outpatient Survey of Antidepressant Prescription Habits

1986 ◽  
Vol 20 (4) ◽  
pp. 487-491 ◽  
Author(s):  
Geoffrey D. Schrader ◽  
Andrew Gibbs ◽  
Robert G. Harcourt
Keyword(s):  
General Hospital ◽  
Outpatient Clinic ◽  
Depressive Disorders ◽  
Low Doses ◽  
Neurotic Disorders ◽  
Psychiatric Outpatient ◽  
Antidepressant Prescription ◽  
Psychiatric Outpatient Clinic

A review of case notes of patients attending a general hospital psychiatric outpatient clinic revealed that 75% of patients with depressive disorders and 38% of patients with neurotic disorders were prescribed antidepressants. Antidepressants were often prescribed for long periods in low doses and in combination with benzodiazepines. There was less polypharmacy, however, with more sedating antidepressants. The results indicate that clinical prescription habits for antidepressants may still be at some variance with recommendations from the literature.

Antidepressant Prescription in the Geriatric Population

2016 ◽  
Vol 176 (11) ◽  
pp. 1608 ◽  
Author(s):  
Avash Das ◽  
Abhishek Maiti ◽  
Shirshendu Sinha
Keyword(s):  
Geriatric Population ◽  
Antidepressant Prescription

Antidepressant use in Alzheimer's disease patients: results of the REAL.FR cohort

2009 ◽  
Vol 22 (1) ◽  
pp. 120-128 ◽  
Author(s):  
Christophe Arbus ◽  
Virginie Gardette ◽  
Eric Bui ◽  
Christelle Cantet ◽  
Sandrine Andrieu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Depressive Symptoms ◽  
Previous History ◽  
Natural Setting ◽  
Antidepressant Prescription ◽  
History Of ◽  
Antidepressant Use ◽  
Clinically Significant ◽  
History Of Depression

ABSTRACTBackground: Psychotropic medication is widely prescribed in clinical practice for the management of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD). However, there have been few pharmaco-epidemiological studies or studies conducted in a natural setting on the real use of antidepressants in AD. The aim of this survey was to assess the prevalence of antidepressant use in AD and to identify the clinical factors associated with antidepressant prescription.Methods: REAL.FR is a four-year, prospective, multi-center study. Baseline data including demographic characteristics, clinical variables and drug intake were obtained. Depressive symptoms were determined using the Neuropsychiatric Inventory (NPI).Results: A total of 686 AD patients were included. Antidepressant treatment was prescribed for 34.8% of patients. Clinically significant depressive symptoms (NPI ≥ 4) were observed in 20.5% of the total population. Although depressed subjects were significantly more likely to be treated with antidepressants than non-depressed subjects (p<0.0001), only 60% of depressed subjects overall were prescribed an antidepressant. In multivariate analysis, clinically significant depressive symptoms were associated with antidepressant prescription although this result was only observed in subjects without a previous history of depression.Conclusions: The available data on antidepressant efficacy in BPSD other than depression (in particular, agitation, aggression and, occasionally, psychotic symptoms) do not influence prescription choices. Depressive symptoms may be taken more seriously in the absence of a previous history of depression, leading to increased antidepressant prescription rates in individuals presenting with depression for the first time.

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