A Novel Method for the Automatic Generation of JOP Chain Exploits

Author(s):  
Bramwell Brizendine ◽  
Austin Babcock
2004 ◽  
Vol 859 ◽  
Author(s):  
Talat S. Rahman ◽  
Abdelkader Kara ◽  
Altaf Karim ◽  
Oleg Trushin

ABSTRACTThe Kinetic Monte Carlo (KMC) method has become an important tool for examination of phenomena like surface diffusion and thin film growth because of its ability to carry out simulations for time scales that are relevant to experiments. But the method generally has limited predictive power because of its reliance on predetermined atomic events and their energetics as input. We present a novel method, within the lattice gas model in which we combine standard KMC with automatic generation of a table of microscopic events, facilitated by a pattern recognition scheme. Each time the system encounters a new configuration, the algorithm initiates a procedure for saddle point search around a given energy minimum. Nontrivial paths are thus selected and the fully characterized transition path is permanently recorded in a database for future usage. The system thus automatically builds up all possible single and multiple atom processes that it needs for a sustained simulation. Application of the method to the examination of the diffusion of 2-dimensional adatom clusters on Cu(111) displays the key role played by specific diffusion processes and also reveals the presence of a number of multiple atom processes, whose importance is found to decrease with increasing cluster size and decreasing surface temperature. Similarly, the rate limiting steps in the coalescence of adatom islands are determined. Results are compared with those from experiments where available and with those from KMC simulations based on a fixed catalogue of diffusion processes.


2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Sebastian Carrasco Pro ◽  
John Sidney ◽  
Sinu Paul ◽  
Cecilia Lindestam Arlehamn ◽  
Daniela Weiskopf ◽  
...  

Accurate measurement of B and T cell responses is a valuable tool to study autoimmunity, allergies, immunity to pathogens, and host-pathogen interactions and assist in the design and evaluation of T cell vaccines and immunotherapies. In this context, it is desirable to elucidate a method to select validated reference sets of epitopes to allow detection of T and B cells. However, the ever-growing information contained in the Immune Epitope Database (IEDB) and the differences in quality and subjects studied between epitope assays make this task complicated. In this study, we develop a novel method to automatically select reference epitope sets according to a categorization system employed by the IEDB. From the sets generated, three epitope sets (EBV, mycobacteria and dengue) were experimentally validated by detection of T cell reactivityex vivofrom human donors. Furthermore, a web application that will potentially be implemented in the IEDB was created to allow users the capacity to generate customized epitope sets.


Author(s):  
Santhakumar R ◽  
E R Rajkumar ◽  
Megha Tandur ◽  
Geetha K S ◽  
Kumar Thirunellai Rajamani ◽  
...  

Author(s):  
M.A. Gregory ◽  
G.P. Hadley

The insertion of implanted venous access systems for children undergoing prolonged courses of chemotherapy has become a common procedure in pediatric surgical oncology. While not permanently implanted, the devices are expected to remain functional until cure of the primary disease is assured. Despite careful patient selection and standardised insertion and access techniques, some devices fail. The most commonly encountered problems are colonisation of the device with bacteria and catheter occlusion. Both of these difficulties relate to the development of a biofilm within the port and catheter. The morphology and evolution of biofilms in indwelling vascular catheters is the subject of ongoing investigation. To date, however, such investigations have been confined to the examination of fragments of biofilm scraped or sonicated from sections of catheter. This report describes a novel method for the extraction of intact biofilms from indwelling catheters.15 children with Wilm’s tumour and who had received venous implants were studied. Catheters were removed because of infection (n=6) or electively at the end of chemotherapy.


GeroPsych ◽  
2012 ◽  
Vol 25 (4) ◽  
pp. 235-245 ◽  
Author(s):  
Katja Franke ◽  
Christian Gaser

We recently proposed a novel method that aggregates the multidimensional aging pattern across the brain to a single value. This method proved to provide stable and reliable estimates of brain aging – even across different scanners. While investigating longitudinal changes in BrainAGE in about 400 elderly subjects, we discovered that patients with Alzheimer’s disease and subjects who had converted to AD within 3 years showed accelerated brain atrophy by +6 years at baseline. An additional increase in BrainAGE accumulated to a score of about +9 years during follow-up. Accelerated brain aging was related to prospective cognitive decline and disease severity. In conclusion, the BrainAGE framework indicates discrepancies in brain aging and could thus serve as an indicator for cognitive functioning in the future.


Author(s):  
Luisa Lugli ◽  
Stefania D’Ascenzo ◽  
Roberto Nicoletti ◽  
Carlo Umiltà

Abstract. The Simon effect lies on the automatic generation of a stimulus spatial code, which, however, is not relevant for performing the task. Results typically show faster performance when stimulus and response locations correspond, rather than when they do not. Considering reaction time distributions, two types of Simon effect have been individuated, which are thought to depend on different mechanisms: visuomotor activation versus cognitive translation of spatial codes. The present study aimed to investigate whether the presence of a distractor, which affects the allocation of attentional resources and, thus, the time needed to generate the spatial code, changes the nature of the Simon effect. In four experiments, we manipulated the presence and the characteristics of the distractor. Findings extend previous evidence regarding the distinction between visuomotor activation and cognitive translation of spatial stimulus codes in a Simon task. They are discussed with reference to the attentional model of the Simon effect.


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