Assessment of Fatigue Based on Workload and Rest Activity Cycles—A Pilot Study

2021 ◽  
pp. 261-272
Author(s):  
E. A. Stradioto Neto ◽  
D. Bustos ◽  
J. C. Guedes
Keyword(s):  
Pilot Study ◽  
Activity Cycles ◽  
Rest Activity

scholarly journals Rest-activity cycles and melatonin phase angle of circadian entrainment in people without cone-mediated vision

2020 ◽  
Author(s):  
Manuel Spitschan ◽  
Corrado Garbazza ◽  
Susanne Kohl ◽  
Christian Cajochen
Keyword(s):  
Ganglion Cells ◽  
Light Exposure ◽  
Activity Patterns ◽  
External World ◽  
Circadian Phase ◽  
Cone System ◽  
Retinohypothalamic Tract ◽  
Activity Cycles ◽  
Phase Angles ◽  
Rest Activity

AbstractLight is strong zeitgeber to the human circadian system, entraining internal rhythms in physiology and behaviour to the external world. This is mediated by the melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), which sense light in addition to the classical photoreceptors, the cones and rods. Circadian responses depend on light intensity, with exposure to brighter light leading to bigger circadian phase shifts and melatonin suppression. In congenital achromatopsia (prevalence 1 in 30,000 to 50,000 people), the cone system is non-functional, resulting in light avoidance and photophobia at light levels which are tolerable and habitual to individuals with a normal, trichromatic retina. Here, we examined chronotype and self-reported sleep, actigraphy-derived rest-activity cycles and increases melatonin in the evening in a group of genetically confirmed congenital achromats. We found normal rest-activity patterns in all participants, and normal melatonin phase angles of entrainment in 2/3 of our participants. Our results suggest that a functional cone system and exposure to daytime light intensities are not necessary for regular behavioural and hormonal entrainment. This may point to a compensation mechanism in circadian photoreception, which in conjunction with non-photic zeitgebers, ensures synchronisation of activity to the external world.Significance statementRhythms in physiology and behaviour are synchronised to the external cycle of light exposure. This is mediated by the retinohypothalamic tract, which connects the photoreceptors in the eye with the “circadian pacemaker” in our brain, the suprachiasmatic nucleus. What happens to our circadian rhythm when we lack the cone photoreceptors in the eye that enable us to see in daylight? We examined this question in a group of rare congenital achromats. Our work reveals that normal rhythms in rest and activity, and production of hormones, does not require a functional cone system.

scholarly journals Photoperiodic Requirements for Induction and Maintenance of Rhythm Bifurcation and Extraordinary Entrainment in Male Mice

2019 ◽  
Vol 1 (3) ◽  
pp. 290-305 ◽  
Author(s):  
Jonathan Sun ◽  
Deborah A. M. Joye ◽  
Andrew H. Farkas ◽  
Michael R. Gorman
Keyword(s):  
Male Mice ◽  
Shift Workers ◽  
Circadian Timing ◽  
Non Invasive ◽  
Circadian Control ◽  
Timing System ◽  
Circadian Timing System ◽  
Activity Cycles ◽  
Rest Activity

Exposure of mice to a 24 h light:dark:light:dark (LDLD) cycle with dimly illuminated nights induces the circadian timing system to program two intervals of activity and two intervals of rest per 24 h cycle and subsequently allows entrainment to a variety of extraordinary light regimens including 30 h LDLD cycles. Little is known about critical lighting requirements to induce and maintain this non-standard entrainment pattern, termed “bifurcation,” and to enhance the range of apparent entrainment. The current study determined the necessary duration of the photophase for animals to bifurcate and assessed whether requirements for maintenance differed from those for induction. An objective index of bifurcated entrainment varied with length of the photophase over 4–10 h durations, with highest values at 8 h. To assess photic requirements for the maintenance of bifurcation, mice from each group were subsequently exposed to the LDLD cycle with 4 h photophases. While insufficient to induce bifurcation, this photoperiod maintained bifurcation in mice transferred from inductive LDLD cycles. Entrainment to 30 h LDLD cycles also varied with photoperiod duration. These studies characterize non-invasive tools that reveal latent flexibility in the circadian control of rest/activity cycles with important translational potential for addressing needs of human shift-workers.

The fragmentation of rest/activity cycles in Alzheimer's disease

1995 ◽  
Vol 10 (4) ◽  
pp. 299-304 ◽  
Author(s):  
Laura Ghali ◽  
Robert W. Hopkins ◽  
Peter Rindlisbacher
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Activity Cycles ◽  
Rest Activity

scholarly journals The Relationship between Fatigue and Actigraphy-Derived Sleep and Rest-Activity Patterns in Cancer Survivors

2019 ◽  
Author(s):  
Tristan Martin ◽  
Rosemary Twomey ◽  
Mary E Medysky ◽  
John Temesi ◽  
S. Nicole Culos-Reed ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Activity Patterns ◽  
Sleep Onset ◽  
Activity Cycle ◽  
Objective Measures ◽  
Sleep Onset Latency ◽  
Cancer Related Fatigue ◽  
Wrist Actigraphy ◽  
Activity Cycles ◽  
Rest Activity

Background: Cancer-related fatigue can continue long after curative cancer treatment. The aim of this study was to investigate sleep and rest-activity cycles in fatigued and non-fatigued cancer survivors. We hypothesized that sleep and rest-activity cycles would be more disturbed in people experiencing clinically-relevant fatigue, and that objective measures of sleep would be associated with the severity of fatigue in cancer survivors.Methods: Cancer survivors (n=87) completed a 14-day wrist actigraphy measurement for the estimation of sleep and rest-activity cycles. Fatigue was measured using the Functional Assessment of Chronic Illness Therapy-Fatigue Scale (FACIT-F). Participants were dichotomised into two groups using a previously validated score (fatigued n=51 and non-fatigued n=36). Perception of sleep was measured using the Insomnia Severity Index (ISI).Results: FACIT-F score was correlated with wake after sleep onset (r =-0.28; p = 0.010), sleep efficiency (r=0.26; p=0.016), sleep onset latency (r=-0.31; p=0.044) and ISI score (r=-0.56; p <0.001). The relative amplitude of the rest-activity cycles was lower in the fatigued vs. non-fatigued group (p=0.017; d=0.58). Conclusions: After treatment for cancer, the severity of cancer-related fatigue is correlated with specific objective measures of sleep, and there is evidence of rest-activity cycle disruption in people experiencing clinically-relevant fatigue.

Measurement of rest and activity in newborn lambs using actigraphy: studies in term and preterm lambs

2008 ◽  
Vol 20 (3) ◽  
pp. 418 ◽  
Author(s):  
D. W. Rurak ◽  
S. Fay ◽  
N. C. Gruber
Keyword(s):  
Maternal Care ◽  
Bone Growth ◽  
Perinatal Period ◽  
Activity Monitor ◽  
Progressive Increase ◽  
Male And Female ◽  
Hormonal Profiles ◽  
Activity Measurements ◽  
Activity Cycles ◽  
Rest Activity

The present study used actigraphy to monitor rest–activity cycles in lambs. We employed an Actiwatch Activity Monitor, which was secured on the lamb’s neck in 13 term lambs and six preterm lambs. Activity measurements began on the day of delivery and lasted for 7.3 ± 0.7 days. All lambs exhibited bouts of activity, lasting from ~2 to 60 min, separated by periods of inactivity of about equal duration. There was a progressive increase in the frequency and intensity of activity bouts with age, and a decrease in duration. In relation to postnatal age, preterm lambs had a significantly lower frequency and intensity of activity bouts compared with term lambs and significantly longer mean active bout duration. However, in relation to post-conceptual age, preterm animals were less active at birth, but thereafter the trajectory for activity development was steeper compared with the term lambs. These differences between term and preterm lambs may be due to several factors including differences in: (1) the lengths of time the two groups spent in utero and as neonates as a proportion of the perinatal period, which could influence the rate of muscle and bone growth; (2) prenatal and postnatal hormonal profiles; and (3) maternal care. We also found differences in postnatal motility in male and female lambs, with the trajectory of activity increasing in males at Days 4–5, which could be due, in part at least, to sex differences in both prenatal and postnatal hormonal profiles.

scholarly journals Advanced phases and reduced amplitudes are suggested to characterize the daily rest-activity cycles in depressed adolescent boys

2017 ◽  
Vol 34 (7) ◽  
pp. 967-976 ◽  
Author(s):  
Ilona Merikanto ◽  
Timo Partonen ◽  
Tiina Paunio ◽  
Anu E. Castaneda ◽  
Mauri Marttunen ◽  
...  
Keyword(s):  
Adolescent Boys ◽  
Depressed Adolescent ◽  
Activity Cycles ◽  
Rest Activity

Rest-Activity Cycles in Childhood and Adolescent Depression

2004 ◽  
Vol 43 (6) ◽  
pp. 761-769 ◽  
Author(s):  
Roseanne Armitage ◽  
Robert Hoffmann ◽  
Graham Emslie ◽  
Jeanne Rintelman ◽  
Jarrette Moore ◽  
...  
Keyword(s):  
Adolescent Depression ◽  
Activity Cycles ◽  
Rest Activity

SLEEP CYCLE CHARACTERISTICS IN INFANTS

PEDIATRICS ◽  
1969 ◽  
Vol 43 (1) ◽  
pp. 65-70
Author(s):  
Evelyn Stern ◽  
Arthur H. Parmelee ◽  
Yoshio Akiyama ◽  
Marvin A. Schultz ◽  
Waldemar H. Wenner
Keyword(s):  
Cycle Length ◽  
Activity Cycle ◽  
Sleep Cycle ◽  
Normal Brain ◽  
Active Sleep ◽  
Quiet Sleep ◽  
Activity Cycles ◽  
Significant Measure ◽  
Polygraphic Recording ◽  
Rest Activity

Within the sleep of adults and infants there are cyclic fluctuations between quiet and active sleep. These fluctuations may also persist during wakefulness as rest-activity cycles but are less readily detected. They constitute a fundamental biological rhythm on which other daily rhythms are superimposed. In adults the rest-activity cycle is 90 minutes in duration. The quiet-active sleep cycles of term, 3-, and 8-month-old infants were determined by polygraphic recording of eye and body movements, respirations, and electroencephalogram. The cycle length at term was 47 minutes and 49 and 50 minutes at 3 and 8 months. The increase in cycle length with maturation was not significant, but there was a significant change in the proportion of quiet to active sleep within a cycle. At term they were equal, while at 8 months quiet sleep was twice as long as active sleep. Quiet sleep is a highly controlled state requiring complex feedback mechanisms. The increasing proportion of quiet sleep may be a significant measure of normal brain development.

Effects of Melatonin in Two Individuals with Alzheimer's Disease

1998 ◽  
Vol 87 (1) ◽  
pp. 331-339 ◽  
Author(s):  
Girardin Jean-Louis ◽  
Ferdinand Zizi ◽  
Hans Von Gizycki ◽  
Harvey Taub
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Circadian Rhythm ◽  
Aging Process ◽  
Activity Rhythm ◽  
The Other ◽  
Beneficial Effects ◽  
Melatonin Administration ◽  
Activity Cycles ◽  
Rest Activity

Dementia has been associated with circadian rhythm disturbances expressed in several dimensions including body temperature, hormonal concentrations, sleep and wakefulness patterns, and rest-activity cycles. These disturbances may be the result of a dampening in the amplitude of the circadian rhythm. One of the symptoms associated with the aging process has been a decline in the amplitude of the melatonin rhythm. Here, the results of melatonin administration to two patients with Alzheimer's disease are presented. Melatonin administration enhanced and stabilized the circadian rest-activity rhythm in one of the patients along with some reduction of daytime sleepiness and an improvement in mood. The other patient, who was characterized by less cognitive impairment, showed no significant changes associated with melatonin ingestion. Interestingly, the acrophase of rest-activity was delayed for about one hour in both patients. These results suggest that melatonin may have beneficial effects in some patients with Alzheimer's disease

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