On the Influence of Constitutive Models on Shape Optimization for Artificial Blood Pumps

2011 ◽  
pp. 611-622
Author(s):  
Markus Probst ◽  
Michael Lülfesmann ◽  
Mike Nicolai ◽  
H. Martin Bücker ◽  
Marek Behr ◽  
...  
Keyword(s):  
Shape Optimization ◽  
Constitutive Models ◽  
Artificial Blood ◽  
Blood Pumps

COMPARATIVE STUDY OF RIGID VS FLEXIBLE PNEUMATIC ARTIFICIAL BLOOD PUMPS

ASAIO Journal ◽  
1979 ◽  
Vol 25 (1) ◽  
pp. 268-274 ◽  
Author(s):  
M. Nosé ◽  
A. K. Vakamudi ◽  
T. Kudo ◽  
T. Akutsu ◽  
N. H. C. Hwang
Keyword(s):  
Comparative Study ◽  
Artificial Blood ◽  
Blood Pumps

Comparison of LVAD Design Variants Using CFD Computed Thrombus Susceptibility Parameter

2008 ◽  
Author(s):  
Richard B. Medvitz ◽  
Eric G. Paterson
Keyword(s):  
Flow Field ◽  
Thrombus Formation ◽  
Shear Stresses ◽  
Residence Times ◽  
Animal Testing ◽  
Fluid Shear ◽  
Artificial Blood ◽  
Blood Pumps

The 70cc LionHeart was developed for use in patients weighing more than 70 kg, which prevents its use in many women, smaller men, and children. Scaled-down devices have been prone to thrombus formation during animal testing [1, 2]. It is suspected that the increased level of thrombosis is related to changes in the flow field when scaling from the 70cc to the 50cc device. Low fluid shear stresses and high residence times are traits that are believed to influence thrombus formation and deposition within artificial blood pumps [1].

The Status of Failure and Reliability Testing of Artificial Blood Pumps

ASAIO Journal ◽  
2005 ◽  
Vol 51 (4) ◽  
pp. 440-451 ◽  
Author(s):  
Sonna M. Patel ◽  
Amy L. Throckmorton ◽  
Alexandrina Untaroiu ◽  
Paul E. Allaire ◽  
Houston G. Wood ◽  
...  
Keyword(s):  
Reliability Testing ◽  
Artificial Blood ◽  
Blood Pumps ◽  
The Status

scholarly journals On the Design of Innovative Heterogeneous Sheet Metal Tests Using a Shape Optimization Approach

Metals ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 371
Author(s):  
António Andrade-Campos ◽  
José Aquino ◽  
João Martins ◽  
Bernardete Coelho
Keyword(s):  
Shape Optimization ◽  
Mechanical Test ◽  
Ritz Method ◽  
Constitutive Models ◽  
Optimization Methods ◽  
Mechanical Tests ◽  
Material Behavior ◽  
Optimization Approach ◽  
Full Field ◽  
Strain Paths

The development of full-field measurement methods has enabled a new trend of heterogeneous mechanical tests. The inhomogeneous strain fields retrieved from these tests are being widely used in the calibration of constitutive models for sheet metals. However, today, there is no mechanical test able to characterize the material in a large range of strain states. The aim of this work is to present a heterogeneous mechanical test with an innovative tool/specimen shape, capable of producing rich heterogeneous strain paths and thus providing extensive information on material behavior. The proposed specimen is found using a shape optimization process where an index that evaluates the richness of strain information is used. In this work, the methodology and results are extended to non-specimen geometry dependence and to the non-dependence of the geometry parametrization through the use of the Ritz method for boundary value problems. Different curve models, such as splines, B-splines, and NURBS, are used, and C1 continuity throughout the specimen is guaranteed. Moreover, several deterministic and stochastic optimization methods are used in order to find the method or the combination of methods able to minimize the cost function effectively. Results demonstrated that the solution is dependent on the geometry definition, as well as on the optimization methodology. Nevertheless, the obtained solutions provided a wider spectrum of strain states than standard tests.

EXPERIMENTAL FLUID MECHANICS OF PULSATILE ARTIFICIAL BLOOD PUMPS

2006 ◽  
Vol 38 (1) ◽  
pp. 65-86 ◽  
Author(s):  
Steven Deutsch ◽  
John M. Tarbell ◽  
Keefe B. Manning ◽  
Gerson Rosenberg ◽  
Arnold A. Fontaine
Keyword(s):  
Fluid Mechanics ◽  
Artificial Blood ◽  
Experimental Fluid Mechanics ◽  
Blood Pumps ◽  
Experimental Fluid

Particle Tracking Computational Prediction of Hemolysis by Blade of Micro-Axial Blood Pump

2010 ◽  
Vol 160-162 ◽  
pp. 1779-1786
Author(s):  
Xin Chen ◽  
Jian Ping Tan ◽  
Zhong Yun
Keyword(s):  
Blood Flow ◽  
Fluid Dynamic ◽  
Computational Prediction ◽  
Blood Pump ◽  
Navier Stokes ◽  
Initial Attempt ◽  
Navier Stokes Equation ◽  
Artificial Blood ◽  
Blood Damage ◽  
Blood Pumps

By analyzing fluid dynamics of blood in an artificial blood pump and simulating the flow field structure and the flow performance of blood, the blood flow and the damages in the designed blood pump would be better understood. This paper describes computational fluid dynamic (CFD) used in predicting numerically the hemolysis of blade in micro-axial blood pumps. A numerical hydrodynamical model, based on the Navier-Stokes equation, was used to obtain the flow in a micro-axial blood pump. A time-dependent stress acting on blood particle is solved in this paper to explore the blood flow and damages in the micro-axial blood pump. An initial attempt is also made to predict the blood damage from these simulations.

Sinusoidal Cells in Bone Marrow Take Up BSA-Au Conjugates in the Presence of an Artificial Blood Substitute

1985 ◽  
Vol 43 ◽  
pp. 700-701
Author(s):  
J.S. Geoffroy ◽  
R.P. Becker
Keyword(s):  
Bone Marrow ◽  
Los Angeles ◽  
Iliac Artery ◽  
Blood Substitute ◽  
Sprague Dawley ◽  
Coated Pits ◽  
Sinusoidal Cells ◽  
Artificial Blood ◽  
Left Common Iliac Artery

The pattern of BSA-Au uptake in vivo by endothelial cells of the venous sinuses (sinusoidal cells) of rat bone marrow has been described previously. BSA-Au conjugates are taken up exclusively in coated pits and vesicles, enter and pass through an “endosomal” compartment comprised of smooth-membraned tubules and vacuoles and cup-like bodies, and subsequently reside in multivesicular and dense bodies. The process is very rapid, with BSA-Au reaching secondary lysosmes one minute after presentation. (Figure 1)In further investigations of this process an isolated limb perfusion method using an artificial blood substitute, Oxypherol-ET (O-ET; Alpha Therapeutics, Los Angeles, CA) was developed. Under nembutal anesthesia, male Sprague-Dawley rats were laparotomized. The left common iliac artery and vein were ligated and the right iliac artery was cannulated via the aorta with a small vein catheter. Pump tubing, preprimed with oxygenated 0-ET at 37°C, was connected to the cannula.

Artificial blood

Nature ◽  
1998 ◽  
Author(s):  
Helen Phillips
Keyword(s):  
Artificial Blood
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