Particle Tracking Computational Prediction of Hemolysis by Blade of Micro-Axial Blood Pump

2010 ◽  
Vol 160-162 ◽  
pp. 1779-1786
Author(s):  
Xin Chen ◽  
Jian Ping Tan ◽  
Zhong Yun
Keyword(s):  
Blood Flow ◽  
Fluid Dynamic ◽  
Computational Prediction ◽  
Blood Pump ◽  
Navier Stokes ◽  
Initial Attempt ◽  
Navier Stokes Equation ◽  
Artificial Blood ◽  
Blood Damage ◽  
Blood Pumps

By analyzing fluid dynamics of blood in an artificial blood pump and simulating the flow field structure and the flow performance of blood, the blood flow and the damages in the designed blood pump would be better understood. This paper describes computational fluid dynamic (CFD) used in predicting numerically the hemolysis of blade in micro-axial blood pumps. A numerical hydrodynamical model, based on the Navier-Stokes equation, was used to obtain the flow in a micro-axial blood pump. A time-dependent stress acting on blood particle is solved in this paper to explore the blood flow and damages in the micro-axial blood pump. An initial attempt is also made to predict the blood damage from these simulations.

Computational Prediction of Hemolysis by Blade Flow Field of Micro-Axial Blood Pump

2006 ◽  
Author(s):  
Xin Chen ◽  
Jianping Tan
Keyword(s):  
Blood Flow ◽  
Flow Field ◽  
Fluid Dynamic ◽  
Computational Prediction ◽  
Blood Pump ◽  
Navier Stokes ◽  
Initial Attempt ◽  
Navier Stokes Equation ◽  
Blood Damage ◽  
Blood Pumps

By analyzing fluid dynamics of blood in an artificial blood pump and simulating the flow field structure and the flow performance of blood, the blood flow and the damages in the designed blood pump would be better understood. This paper describes computational fluid dynamic (CFD) used in predicting numerically the hemolysis of blade in micro-axial blood pumps. A numerical hydrodynamical model, based on the Navier-Stokes equation, was used to obtain the flow in a micro-axial blood pump. A time-dependent stress acting on blood particle is solved in this paper to explore the blood flow and damages in the micro-axial blood pump. An initial attempt is also made to predict the blood damage from these simulations.

scholarly journals Physiologic blood flow is turbulent

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Khalid M. Saqr ◽  
Simon Tupin ◽  
Sherif Rashad ◽  
Toshiki Endo ◽  
Kuniyasu Niizuma ◽  
...  
Keyword(s):  
Blood Flow ◽  
Stokes Equation ◽  
Initial Conditions ◽  
Hydrodynamic Instability ◽  
Transition To Turbulence ◽  
Navier Stokes ◽  
Navier Stokes Equation ◽  
Frequency Spectra ◽  
Hydrodynamic Stability Theory

Abstract Contemporary paradigm of peripheral and intracranial vascular hemodynamics considers physiologic blood flow to be laminar. Transition to turbulence is considered as a driving factor for numerous diseases such as atherosclerosis, stenosis and aneurysm. Recently, turbulent flow patterns were detected in intracranial aneurysm at Reynolds number below 400 both in vitro and in silico. Blood flow is multiharmonic with considerable frequency spectra and its transition to turbulence cannot be characterized by the current transition theory of monoharmonic pulsatile flow. Thus, we decided to explore the origins of such long-standing assumption of physiologic blood flow laminarity. Here, we hypothesize that the inherited dynamics of blood flow in main arteries dictate the existence of turbulence in physiologic conditions. To illustrate our hypothesis, we have used methods and tools from chaos theory, hydrodynamic stability theory and fluid dynamics to explore the existence of turbulence in physiologic blood flow. Our investigation shows that blood flow, both as described by the Navier–Stokes equation and in vivo, exhibits three major characteristics of turbulence. Womersley’s exact solution of the Navier–Stokes equation has been used with the flow waveforms from HaeMod database, to offer reproducible evidence for our findings, as well as evidence from Doppler ultrasound measurements from healthy volunteers who are some of the authors. We evidently show that physiologic blood flow is: (1) sensitive to initial conditions, (2) in global hydrodynamic instability and (3) undergoes kinetic energy cascade of non-Kolmogorov type. We propose a novel modification of the theory of vascular hemodynamics that calls for rethinking the hemodynamic–biologic links that govern physiologic and pathologic processes.

Human Aorta Buckling Related to Dissection

2010 ◽  
Author(s):  
Kostas Karagiozis ◽  
Marco Amabili ◽  
Rosaire Mongrain ◽  
Raymond Cartier ◽  
Michael P. Pai¨doussis
Keyword(s):  
Blood Flow ◽  
Nonlinear Stability ◽  
Shell Theory ◽  
Inviscid Flow ◽  
Mechanical Stresses ◽  
Surrounding Tissue ◽  
Navier Stokes ◽  
Human Aorta ◽  
Navier Stokes Equation ◽  
Viscous Stresses

Human aortas are subjected to large mechanical stresses and loads due to blood flow pressurization and through contact with the surrounding tissue and muscle. It is essential that the aorta does not lose stability for proper functioning. The present work investigates the buckling of human aorta relating it to dissection by means of an analytical model. A full bifurcation analysis is used employing a nonlinear model to investigate the nonlinear stability of the aorta conveying blood flow. The artery is modeled as a shell by means of Donnell’s nonlinear shell theory retaining in-plane inertia, while the fluid is modelled by a Newtonian inviscid flow theory but taking into account viscous stresses via the time-averaged Navier-Stokes equation. The three shell displacements are expanded using trigonometric series that satisfy the boundary conditions exactly. A parametric study is undertaken to determine the effect of aorta length, thickness, Young’s modulus, and transmural pressure on the nonlinear stability of the aorta. As a first attempt to study dissection, a quasi-steady approach is taken, in which the flow is not pulsatile but steady. The effect of increasing flow velocity is studied, particularly where the system loses stability, exhibiting static collapse. Regions of large mechanical stresses on the artery surface are identified for collapsed arteries indicating possible ways for dissection to be initiated.

scholarly journals Effects of Stenting on Blood Flow in a Coronary Artery Network Model

2006 ◽  
Vol 3 (2) ◽  
pp. 77-86
Author(s):  
R. Raghu ◽  
A. Pullan ◽  
N. Smith
Keyword(s):  
Blood Flow ◽  
Coronary Artery ◽  
Finite Difference Method ◽  
Vessel Wall ◽  
Flow Patterns ◽  
Navier Stokes ◽  
Pressure Gradients ◽  
Computationally Efficient ◽  
Navier Stokes Equation ◽  
Local Flow

The effect of stenting on blood flow is investigated using a model of the coronary artery network. The parameters in a generic non-linear pressure–radius relationship are varied in the stented region to model the increase in stiffness of the vessel due to the presence of the stent. A computationally efficient form of the Navier–Stokes equation is solved using a Lax–Wendroff finite difference method. Pressure, vessel radius and flow velocity are computed along the vessel segments. Results show negative pressure gradients at the ends of the stent and increased velocity through the middle of the stented region. Changes in local flow patterns and vessel wall stresses due to the presence of the stent have been shown to be important in restenosis of vessels. Local and global pressure gradients affect local flow patterns and vessel wall stresses, and therefore may be an important factor associated with restenosis. The model presented in this study can be easily extended to solve flows for stented vessels in a full, anatomically realistic coronary network. The framework to allow for the effects of the deformation of the myocardium on the coronary network is also in place.

Grid-Induced Numerical Errors for Shear Stresses and Essential Flow Variables in a Ventricular Assist Device: Crucial for Blood Damage Prediction?

2018 ◽  
Vol 3 (4) ◽  
Author(s):  
Lucas Konnigk ◽  
Benjamin Torner ◽  
Sebastian Hallier ◽  
Matthias Witte ◽  
Frank-Hendrik Wurm
Keyword(s):  
Shear Stress ◽  
Prediction Models ◽  
Stokes Equations ◽  
Grid Size ◽  
Blood Pump ◽  
Navier Stokes ◽  
Shear Stresses ◽  
Damage Prediction ◽  
Blood Damage ◽  
Stress Calculation

Adverse events due to flow-induced blood damage remain a serious problem for blood pumps as cardiac support systems. The numerical prediction of blood damage via computational fluid dynamics (CFD) is a helpful tool for the design and optimization of reliable pumps. Blood damage prediction models primarily are based on the acting shear stresses, which are calculated by solving the Navier–Stokes equations on computational grids. The purpose of this paper is to analyze the influence of the spatial discretization and the associated discretization error on the shear stress calculation in a blood pump in comparison to other important flow quantities like the pressure head of the pump. Therefore, CFD analysis using seven unsteady Reynolds-averaged Navier–Stokes (URANS) simulations was performed. Two simple stress calculation indicators were applied to estimate the influence of the discretization on the results using an approach to calculate numerical uncertainties, which indicates discretization errors. For the finest grid with 19 × 106 elements, numerical uncertainties up to 20% for shear stresses were determined, while the pressure heads show smaller uncertainties with a maximum of 4.8%. No grid-independent solution for velocity gradient-dependent variables could be obtained on a grid size that is comparable to mesh sizes in state-of-the-art blood pump studies. It can be concluded that the grid size has a major influence on the shear stress calculation, and therefore, the potential blood damage prediction, and that the quantification of this error should always be taken into account.

scholarly journals An accelerated thrombosis model for computational fluid dynamics simulations in rotary blood pumps

2021 ◽  
Author(s):  
Christopher Blum ◽  
Sascha Groß-Hardt ◽  
Ulrich Steinseifer ◽  
Michael Neidlin
Keyword(s):  
Platelet Activation ◽  
Clinical Data ◽  
Thrombus Formation ◽  
Fluid Dynamic ◽  
Surrogate Marker ◽  
Blood Pump ◽  
Funding Agency ◽  
Heartmate Ii ◽  
Blood Pumps ◽  
Rotary Blood Pumps

AbstractPurposeThrombosis is one of the major complications in blood-carrying medical devices and a better understanding to influence design of such devices is desirable. Over the past years many computational models of thrombosis have been developed. However, open questions remain about the applicability and implementation within a pump development process. The aim of the study was to develop and test a computationally efficient model for thrombus risk prediction in rotary blood pumps.MethodsWe used a two-stage approach to calculate thrombus risk. At the first stage, the velocity and pressure fields were computed by computational fluid dynamic (CFD) simulations. At the second stage, platelet activation by mechanical and chemical stimuli was determined through species transport with an Eulerian approach. The model was implemented in ANSYS CFX and compared with existing clinical data on thrombus deposition within the HeartMate II.ResultsOur model shows good correlation (R2>0.94) with clinical data and identifies the bearing and outlet stator region of the HeartMate II as the location most prone to thrombus formation. The calculation of platelet activation requires an additional 10-20 core hours of computation time.DiscussionThe concentration of activated platelets can be used as a surrogate marker to determine risk regions of thrombus deposition in a blood pump. Model expansion, e.g. by including more chemical species can easily be performed. We make our model openly available by implementing it for the FDA benchmark blood pump.DeclarationsFundingThis research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. Open access funding enabled and organized by Projekt DEAL.Conflict of interestAll of the authors have nothing to disclose.Availability of data and materialThe raw data can be retrieved by request from the authors.Code availabilityThe implementation of the thrombus model in the FDA benchmark blood pump geometry is available on https://doi.org/10.5281/zenodo.5116063.Authors’ contributionsAll authors contributed to the study conception and design. CB developed the numerical model, performed the simulations, gathered, analysed and discussed the results. SGH, MN and US were involved in the analysis and discussion of the results. MN supervised the project. MN and CB wrote the manuscript based on the input of all co-authors. All co-authors read and approved the final version of the manuscript.

Computerized Fluid Dynamic Study of Parameter Effects on the Performance of Coaxial Propellers

2020 ◽  
Vol 17 (7) ◽  
pp. 3237-3242
Author(s):  
Young-Tae Kim ◽  
Chang Hwan Park ◽  
Hak Yoon Kim
Keyword(s):  
Pitch Angle ◽  
Fluid Dynamic ◽  
Three Dimensional ◽  
Navier Stokes ◽  
Navier Stokes Equation ◽  
Steady State Condition ◽  
Performance Variation ◽  
Air Vehicle ◽  
Program Star ◽  
And Control

The computerized fluid dynamic (CFD) analysis was performed for 1.8 m diameter coaxial propellers to be applied to the multi-copter type Personal Air Vehicle (PAV) having conceptually 600 kg of Maximum Take-Off Weight (MTOW). Methods/Statistical analysis: Using the commercial CFD program STAR-CCM+ (13.03.11), the coaxial propellers were analyzed at the same RPM under the steady state condition. The three-dimensional Compressible Reynolds Mean Navier-Stokes equation was applied and the Moving Reference Frame (MRF) technique was used. With the optimum single pitch angle of upper propeller, the lower propeller’s pitch was changed for the varying propeller spacing to identify the performance variation and the interference effect. The lower propeller has to be different pitch setting other than the upper propeller’s optimum pitch angle because of the interfered flow effect between propellers. The propeller spacing is not so sensitive to efficiency if the spacing is more than 0.25 of propeller diameter. Study shows that the identified pitches and spacing of coaxial propellers are essential for designing the configuration and control of multi-copter type PAV which uses variable pitch propellers for safety and efficiency.

Influence of Impeller Design on Hemolysis of an Axial Blood Pump

2011 ◽  
Vol 140 ◽  
pp. 162-166
Author(s):  
Lei Liu ◽  
Fang Qun Wang ◽  
Qin Lin Wu ◽  
Wen Jue Wu ◽  
Kun Xi Qian ◽  
...  
Keyword(s):  
Traditional Method ◽  
Blood Compatibility ◽  
Three Dimensional ◽  
Axial Flow ◽  
Blood Pump ◽  
Design Parameters ◽  
Rotating Speed ◽  
Blood Damage ◽  
Axial Pump ◽  
Blood Pumps

Compared to centrifugal blood pumps, the high rotating speed of axial blood pumps lead to blood damage more easily. In order to improve blood compatibility of the axial blood pump developed by the authors, traditional method and three-dimensional streamlined method are used for axial impeller design, and rapid prototyping with ABS organic materials are adopted. Finally, hydraulic experiments and hemolysis tests have been conducted. The results reveal that the impeller design and the design parameters (diameter and length) affect the hydraulic performance and hemolysis of the axial pump obviously. The hemolysis index in axial flow impeller pump using traditional method is 0.12, while the minimum value of hemolysis index in the streamlined axial blood pump is 0.06, below the permitted hemolysis value of 0.1.

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