The Status of Failure and Reliability Testing of Artificial Blood Pumps

The 70cc LionHeart was developed for use in patients weighing more than 70 kg, which prevents its use in many women, smaller men, and children. Scaled-down devices have been prone to thrombus formation during animal testing [1, 2]. It is suspected that the increased level of thrombosis is related to changes in the flow field when scaling from the 70cc to the 50cc device. Low fluid shear stresses and high residence times are traits that are believed to influence thrombus formation and deposition within artificial blood pumps [1].

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EXPERIMENTAL FLUID MECHANICS OF PULSATILE ARTIFICIAL BLOOD PUMPS

Annual Review of Fluid Mechanics ◽

10.1146/annurev.fluid.38.050304.092022 ◽

2006 ◽

Vol 38 (1) ◽

pp. 65-86 ◽

Cited By ~ 75

Author(s):

Steven Deutsch ◽

John M. Tarbell ◽

Keefe B. Manning ◽

Gerson Rosenberg ◽

Arnold A. Fontaine

Keyword(s):

Fluid Mechanics ◽

Artificial Blood ◽

Experimental Fluid Mechanics ◽

Blood Pumps ◽

Experimental Fluid

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Particle Tracking Computational Prediction of Hemolysis by Blade of Micro-Axial Blood Pump

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.160-162.1779 ◽

2010 ◽

Vol 160-162 ◽

pp. 1779-1786

Author(s):

Xin Chen ◽

Jian Ping Tan ◽

Zhong Yun

Keyword(s):

Blood Flow ◽

Fluid Dynamic ◽

Computational Prediction ◽

Blood Pump ◽

Navier Stokes ◽

Initial Attempt ◽

Navier Stokes Equation ◽

Artificial Blood ◽

Blood Damage ◽

Blood Pumps

By analyzing fluid dynamics of blood in an artificial blood pump and simulating the flow field structure and the flow performance of blood, the blood flow and the damages in the designed blood pump would be better understood. This paper describes computational fluid dynamic (CFD) used in predicting numerically the hemolysis of blade in micro-axial blood pumps. A numerical hydrodynamical model, based on the Navier-Stokes equation, was used to obtain the flow in a micro-axial blood pump. A time-dependent stress acting on blood particle is solved in this paper to explore the blood flow and damages in the micro-axial blood pump. An initial attempt is also made to predict the blood damage from these simulations.

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The study of interfacial reactions of nickel thin films on GaAs

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100074616 ◽

1983 ◽

Vol 41 ◽

pp. 156-157

Author(s):

L.J. Chen ◽

Y.F. Hsieh

Keyword(s):

Thin Films ◽

Integrated Circuits ◽

Interfacial Reactions ◽

Metal Contacts ◽

Nickel Thin Films ◽

Thin Foils ◽

The Status ◽

Si Doped ◽

Electron Microscopes

One measure of the maturity of a device technology is the ease and reliability of applying contact metallurgy. Compared to metal contact of silicon, the status of GaAs metallization is still at its primitive stage. With the advent of GaAs MESFET and integrated circuits, very stringent requirements were placed on their metal contacts. During the past few years, extensive researches have been conducted in the area of Au-Ge-Ni in order to lower contact resistances and improve uniformity. In this paper, we report the results of TEM study of interfacial reactions between Ni and GaAs as part of the attempt to understand the role of nickel in Au-Ge-Ni contact of GaAs.N-type, Si-doped, (001) oriented GaAs wafers, 15 mil in thickness, were grown by gradient-freeze method. Nickel thin films, 300Å in thickness, were e-gun deposited on GaAs wafers. The samples were then annealed in dry N2 in a 3-zone diffusion furnace at temperatures 200°C - 600°C for 5-180 minutes. Thin foils for TEM examinations were prepared by chemical polishing from the GaA.s side. TEM investigations were performed with JE0L- 100B and JE0L-200CX electron microscopes.

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Sinusoidal Cells in Bone Marrow Take Up BSA-Au Conjugates in the Presence of an Artificial Blood Substitute

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100120199 ◽

1985 ◽

Vol 43 ◽

pp. 700-701

Author(s):

J.S. Geoffroy ◽

R.P. Becker

Keyword(s):

Bone Marrow ◽

Los Angeles ◽

Iliac Artery ◽

Blood Substitute ◽

Sprague Dawley ◽

Coated Pits ◽

Sinusoidal Cells ◽

Artificial Blood ◽

Left Common Iliac Artery

The pattern of BSA-Au uptake in vivo by endothelial cells of the venous sinuses (sinusoidal cells) of rat bone marrow has been described previously. BSA-Au conjugates are taken up exclusively in coated pits and vesicles, enter and pass through an “endosomal” compartment comprised of smooth-membraned tubules and vacuoles and cup-like bodies, and subsequently reside in multivesicular and dense bodies. The process is very rapid, with BSA-Au reaching secondary lysosmes one minute after presentation. (Figure 1)In further investigations of this process an isolated limb perfusion method using an artificial blood substitute, Oxypherol-ET (O-ET; Alpha Therapeutics, Los Angeles, CA) was developed. Under nembutal anesthesia, male Sprague-Dawley rats were laparotomized. The left common iliac artery and vein were ligated and the right iliac artery was cannulated via the aorta with a small vein catheter. Pump tubing, preprimed with oxygenated 0-ET at 37°C, was connected to the cannula.

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