The Cell and Tissue Biology

Does the Interaction between Local and Systemic Inflammation Provide a Link from Psychology and Lifestyle to Tissue Health in Musculoskeletal Conditions?

International Journal of Molecular Sciences ◽

10.3390/ijms22147299 ◽

2021 ◽

Vol 22 (14) ◽

pp. 7299

Author(s):

David M. Klyne ◽

Mary F. Barbe ◽

Greg James ◽

Paul W. Hodges

Keyword(s):

Connective Tissue ◽

Systemic Inflammation ◽

Molecular Basis ◽

Tissue Level ◽

Lifestyle Factors ◽

Local Inflammation ◽

Musculoskeletal Conditions ◽

Tissue Biology ◽

Mind And Body

Musculoskeletal conditions are known to involve biological, psychological, social and, often, lifestyle elements. However, these domains are generally considered in isolation from each other. This siloed approach is unlikely to be adequate to understand the complexity of these conditions and likely explains a major component of the disappointing effects of treatment. This paper presents a hypothesis that aims to provide a foundation to understand the interaction and integration between these domains. We propose a hypothesis that provides a plausible link between psychology and lifestyle factors with tissue level effects (such as connective tissue dysregulation/accumulation) in musculoskeletal conditions that is founded on understanding the molecular basis for interaction between systemic and local inflammation. The hypothesis provides plausible and testable links between mind and body, for which empirical evidence can be found for many aspects. We present this hypothesis from the perspective of connective tissue biology and pathology (fibrosis), the role of inflammation locally (tissue level), and how this inflammation is shaped by systemic inflammation through bidirectional pathways, and various psychological and lifestyle factors via their influence on systemic inflammation. This hypothesis provides a foundation for new consideration of the development and refinement of personalized multidimensional treatments for individuals with musculoskeletal conditions.

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Chemotactic cytokines, obesity and type 2 diabetes:in vivoandin vitroevidence for a possible causal correlation?

Proceedings of The Nutrition Society ◽

10.1017/s0029665109990218 ◽

2009 ◽

Vol 68 (4) ◽

pp. 378-384 ◽

Cited By ~ 41

Author(s):

Henrike Sell ◽

Jürgen Eckel

Keyword(s):

Insulin Resistance ◽

Adipose Tissue ◽

Low Grade ◽

Obese Patients ◽

Tissue Mass ◽

Tissue Biology ◽

Wide Range ◽

Adipose Tissue Mass

A strong causal link between increased adipose tissue mass and insulin resistance in tissues such as liver and skeletal muscle exists in obesity-related disorders such as type 2 diabetes. Increased adipose tissue mass in obese patients and patients with diabetes is associated with altered secretion of adipokines, which also includes chemotactic proteins. Adipose tissue releases a wide range of chemotactic proteins including many chemokines and chemerin, which are interesting targets for adipose tissue biology and for biomedical research in obesity and obesity-related diseases. This class of adipokines may be directly linked to a chronic state of low-grade inflammation and macrophage infiltration in adipose tissue, a concept intensively studied in adipose tissue biology in recent years. The inflammatory state of adipose tissue in obese patients may be the most important factor linking increased adipose tissue mass to insulin resistance. Furthermore, chemoattractant adipokines may play an important role in this situation, as many of these proteins possess biological activity beyond the recruitment of immune cells including effects on adipogenesis and glucose homeostasis in insulin-sensitive tissues. The present review provides a summary of experimental evidence of the role of adipose tissue-derived chemotactic cytokines and their function in insulin resistancein vivoandin vitro.

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Pro-resolving actions of SPM in adipose tissue biology

Molecular Aspects of Medicine ◽

10.1016/j.mam.2017.03.004 ◽

2017 ◽

Vol 58 ◽

pp. 83-92 ◽

Cited By ~ 18

Author(s):

Joan Clària ◽

Cristina López-Vicario ◽

Bibiana Rius ◽

Esther Titos

Keyword(s):

Adipose Tissue ◽

Tissue Biology

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Gonadectomy in Mito-Ob mice revealed a sex-dimorphic relationship between prohibitin and sex steroids in adipose tissue biology and glucose homeostasis

Biology of Sex Differences ◽

10.1186/s13293-018-0196-4 ◽

2018 ◽

Vol 9 (1) ◽

Cited By ~ 4

Author(s):

Yang Xin Zi Xu ◽

Sudharsana Rao Ande ◽

Suresh Mishra

Keyword(s):

Adipose Tissue ◽

Glucose Homeostasis ◽

Sex Steroids ◽

Tissue Biology

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Analisis Hambatan Pembelajaran Biologi Materi Jaringan Tumbuhan Dalam Pelaksanaan Kurikulum 2013 Di SMA

Edunesia : Jurnal Ilmiah Pendidikan ◽

10.51276/edu.v1i3.48 ◽

2020 ◽

Vol 1 (3) ◽

pp. 1-8

Author(s):

Evi Susilawati ◽

Khausar Khausar ◽

Rufa Hera

Keyword(s):

Learning Process ◽

Plant Tissue ◽

Barriers To Learning ◽

Tissue Biology ◽

Tissue Material

Abstract: This study aims to determine: 1) barriers to learning biology of plant tissue material in the implementation of 2013 class XI curriculum at SMA Negeri 1 Meureubo; 2) factors inhibiting the learning of plant tissue biology in the implementation of the 2013 XI class curriculum at SMA Negeri 1 Meureubo. This research uses qualitative. From the results of the study, there are obstacles faced by class XI teachers of SMA Negeri 1 Meureubo in the learning process of plant tissue biology in the implementation of the 2013 curriculum, which are the availability of books and supporting infrastructure which are inadequate, too short training, limited use of media, and assessment is so difficult and requires a lot of time. Abstrak: Penelitian ini bertujuan untuk mengetahui: 1) hambatan pembelajaran biologi materi jaringan tumbuhan dalam pelaksanaan kurikulum 2013 kelas XI SMA Negeri 1 Meureubo; 2) faktor-faktor hambatan pembelajaran biologi materi jaringan tumbuhan dalam pelaksanaan kurikulum 2013 kelas XI SMA Negeri 1 Meureubo. Penelitian ini menggunakan kualitatif. Dari hasil penelitian maka terdapat hambatan-hambatan yang dihadapi guru kelas XI SMA Negeri 1 Meureubo dalam proses pembelajaran biologi materi jaringan tumbuhan pada pelaksanaan Kurikulum 2013 adalah ketersediaan buku dan sarana prasarana pendukung yang kurang memadai, pelatihan yang terlalu singkat, penggunaan media yang terbatas, serta penilaian yang begitu sulit serta membutuhkan waktu yang banyak.

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Waisted: The Biology of Body Fat

10.1093/med/9780198865278.001.0001 ◽

2021 ◽

Author(s):

Nathan Denton

Keyword(s):

Adipose Tissue ◽

Body Fat ◽

Fat Distribution ◽

Passive Layer ◽

Evidence Based ◽

Physical And Mental Health ◽

Tissue Biology ◽

Adipose Tissue Dysfunction ◽

Social Meanings ◽

Practical Implications

Waisted outlines the fascinating and misunderstood biology of fat (i.e., adipose tissue). This controversial, much-maligned organ plays a crucial yet curiously overlooked role in the global obesity crisis currently wreaking havoc on the world’s healthcare systems and economies. Attaining a better appreciation of the biology of fat, its social meanings, and how these intersect is essential for improving the world’s physical and mental health. Far from being a passive layer of blubber under the skin, fat plays a highly dynamic role in energy metabolism, reproductive health, and immunity, with these links having ancient origins in the evolution of modern humanity. Waisted provides a comprehensive, evidence-based perspective on the biology of fat and its crucial role in human evolution, health, disease, and society. Waisted draws upon biomedical, epidemiological, and evolutionary research to understand adipose tissue biology and the striking relationship between body fat distribution and health outcomes. Waisted demonstrates the practical implications of key conceptual points through relatable real-world cases and highlights how seemingly disparate common and rare diseases may be underpinned by adipose tissue dysfunction. Overall, Waisted covers a wide breadth of material that challenges and reframes the generally negative perspective of fat to highlight the underappreciated importance of adipose tissue biology in humans.

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