Management of Cervical Dysplasia

Background: Clinicians commonly perform colposcopy directed biopsies on patients with low grade squamous intraepithelial lesion (LSIL) on PAP cytology even when not consistent with clinical guidelines. Objective: We study the association of PAP cytology screening results with cervical intra-epithelia neoplasia (CIN) 2-3 high-grade dysplasia, as confirmed by colposcopy-directed biopsy. Methods: A retrospective study of 263 women with an abnormality on the PAP smear. Multinomial logistic regression was performed with predictors of PAP cytology screening results with the outcome variable of colposcopy-directed biopsy. Results: High grade squamous intraepithelial lesion (HSIL) had significantly increased relative risk for CIN 2-3 (RR: 9.85, 95% CI: 1.84, 52.79, p=0.008). LSIL was not significantly associated with CIN 2-3. In the comparisons of negative with CIN-1, both HSIL and LSIL were not significantly associated with a negative biopsy. Conclusion: HSIL is associated with cervical dysplasia of CIN 2-3 while LSIL is not associated with cervical dysplasia of CIN 2-3. We do not recommend routine biopsies in patients with LSIL cytologic abnormalities unless additional compelling factors exist.

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High-risk HPV-positive and -negative high-grade cervical dysplasia: Analysis of 5-year outcomes

Gynecologic Oncology ◽

10.1016/j.ygyno.2021.01.020 ◽

2021 ◽

Author(s):

Giorgio Bogani ◽

Francesco Sopracordevole ◽

Violante Di Donato ◽

Andrea Ciavattini ◽

Alessandro Ghelardi ◽

...

Keyword(s):

High Risk ◽

Cervical Dysplasia ◽

High Grade ◽

High Risk Hpv

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Attitude and Acceptability of the Self-Sampling in HPV Carrier Women

Hispanic Health Care International ◽

10.1177/15404153211001577 ◽

2021 ◽

pp. 154041532110015

Author(s):

Gloria Maricela Guerra Rodríguez ◽

Octavio Augusto Olivares Ornelas ◽

Héctor Manuel Gil Vázquez ◽

Dalia Sarahí Silguero Esquivel ◽

Jane Dimmitt Champion

Keyword(s):

Cervical Cancer ◽

Age At Onset ◽

Cervical Dysplasia ◽

Diagnostic Procedures ◽

Mexican Women ◽

Cross Sectional ◽

Convenience Sample ◽

Positive Attitudes ◽

Multiple Strains ◽

Cancer Multiple

Human papillomavirus (HPV) is a primary cause of cervical cancer. Multiple strains of HPV lead to cervical intraepithelial injuries that later progress to cervical cancer. The purpose of this study was to assess attitudes toward and acceptability of self-sampling among Mexican women who have HPV. Methods: The descriptive, cross-sectional design included a convenience sample of Mexican women with a previous diagnosis of cervical dysplasia. Results: Women ( n = 61) were young adults ( M = 27 years, SD = 6.92) reporting single marital status (55%) and sexually active (93%). Mean age at onset of sexual activity was 17 years; a majority of women (78.8%) had more than one sexual partner in their lifetime with 56.6% reporting between two and five partners. All (100%) of the women indicated that they would “choose self-sampling for HPV detection” and would recommend it to other women. Concerning “attitudes toward HPV,” the women responded that it is necessary to comply with HPV treatment and understand that preventative measures can avoid HPV transmission. Conclusion: Women reported high acceptability for self-sampling and positive attitudes toward HPV diagnostic procedures. Women indicated substantial interest in learning more about HPV, its transmission, preventive measures, routine testing, and recommended self-sampling for HPV detection.

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