Next-Generation Sequencing Based Testing for Breast Cancer

2016 ◽  
pp. 299-328
Author(s):  
Shridar Ganesan ◽  
Kim M. Hirshfield
Keyword(s):  
Breast Cancer ◽  
Next Generation Sequencing ◽  
Next Generation ◽  
Generation Sequencing

scholarly journals Using next‐generation sequencing to redefine BRCAness in triple‐negative breast cancer

2020 ◽  
Vol 111 (4) ◽  
pp. 1375-1384 ◽  
Author(s):  
Po‐Han Lin ◽  
Ming Chen ◽  
Li‐Wei Tsai ◽  
Chiao Lo ◽  
Tzu‐Chun Yen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Next Generation Sequencing ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Next Generation ◽  
Generation Sequencing

scholarly journals Next-Generation Sequencing–Based Assessment of JAK2, PD-L1, and PD-L2 Copy Number Alterations at 9p24.1 in Breast Cancer

2019 ◽  
Vol 21 (2) ◽  
pp. 307-317 ◽  
Author(s):  
Sounak Gupta ◽  
Chad M. Vanderbilt ◽  
Paolo Cotzia ◽  
Javier A. Arias-Stella ◽  
Jason C. Chang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Next Generation Sequencing ◽  
Copy Number ◽  
Copy Number Alterations ◽  
Next Generation ◽  
Generation Sequencing

scholarly journals The Important Role of Breast Microbiota in Breast Cancer

2020 ◽  
Author(s):  
Kar-Yan Su ◽  
Wai-Leng Lee ◽  
Vinod Balasubramaniam
Keyword(s):  
Breast Cancer ◽  
Next Generation Sequencing ◽  
Racial Differences ◽  
Breast Tissue ◽  
Bacterial Species ◽  
Cancer Therapies ◽  
Next Generation ◽  
Sequencing Technologies ◽  
Health And Disease ◽  
Generation Sequencing

One in eight women will be diagnosed with breast cancer (BC) in their lifetime, resulting in over 2 million cases annually. BC is the most common cancer among women. Unfortunately, the etiology of majority of cases remains unknown. Recently, evidence has shown that the human microbiota plays an important role in health and disease. Intriguingly, studies have revealed the presence of microorganisms in human breast tissue, which was previously presumed to be sterile. Next-generation sequencing technologies have paved way for the investigation of breast microbiota, uncovering bacterial signatures that are associated with BC. Some of the bacterial species were found to possess pro-carcinogenic and/or anti-carcinogenic properties, suggesting that the breast microbiota has potentially crucial roles in maintenance of breast health. In this review, we summarize the recent findings on breast tissue microbiota and its interplay with BC. Bacterial signatures identified via next-generation sequencing as well as their impact on breast carcinogenesis and cancer therapies are reviewed. Correlation of breast tissue microbiota and other factors, such as geographical and racial differences, in BC is discussed. Additionally, we discuss the future directions of research on breast microbiota as well as its potential role in prevention, diagnosis and treatment of BC.

scholarly journals Immunohistochemical analysis of estrogen receptor in breast cancer with ESR1 mutations detected by hybrid capture-based next-generation sequencing

2018 ◽  
Vol 32 (1) ◽  
pp. 81-87 ◽  
Author(s):  
Dara S. Ross ◽  
Ahmet Zehir ◽  
Edi Brogi ◽  
Fumiko Konno ◽  
Melissa Krystel-Whittemore ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Next Generation Sequencing ◽  
Immunohistochemical Analysis ◽  
Next Generation ◽  
Hybrid Capture ◽  
Esr1 Mutations ◽  
Generation Sequencing

scholarly journals Targeted next generation sequencing identifies somatic mutations in a cohort of Egyptian breast cancer patients

2020 ◽  
Vol 24 ◽  
pp. 149-157
Author(s):  
Auhood Nassar ◽  
Mohamed Abouelhoda ◽  
Osman Mansour ◽  
Samah A. Loutfy ◽  
Mohamed M. Hafez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Next Generation Sequencing ◽  
Cancer Patients ◽  
Somatic Mutations ◽  
Next Generation ◽  
Breast Cancer Patients ◽  
Targeted Next Generation Sequencing ◽  
Generation Sequencing
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