scholarly journals Immunohistochemical analysis of estrogen receptor in breast cancer with ESR1 mutations detected by hybrid capture-based next-generation sequencing

2018 ◽  
Vol 32 (1) ◽  
pp. 81-87 ◽  
Author(s):  
Dara S. Ross ◽  
Ahmet Zehir ◽  
Edi Brogi ◽  
Fumiko Konno ◽  
Melissa Krystel-Whittemore ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Next Generation Sequencing ◽  
Immunohistochemical Analysis ◽  
Next Generation ◽  
Hybrid Capture ◽  
Esr1 Mutations ◽  
Generation Sequencing

Broad, hybrid capture-based next generation sequencing identified actionable genomic alterations in HER2-negative breast cancer.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e12544-e12544 ◽  
Author(s):  
Helei Hou ◽  
Dong Liu ◽  
Na Zhou ◽  
Jinping Zhang ◽  
Chuantao Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Next Generation Sequencing ◽  
Next Generation ◽  
Genomic Alterations ◽  
Hybrid Capture ◽  
Generation Sequencing

Detection of ESR1 mutations in plasma and tumors from metastatic breast cancer patients using next-generation sequencing

2017 ◽  
Vol 163 (2) ◽  
pp. 231-240 ◽  
Author(s):  
Takehiro Yanagawa ◽  
Naofumi Kagara ◽  
Tomohiro Miyake ◽  
Tomonori Tanei ◽  
Yasuto Naoi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Next Generation Sequencing ◽  
Cancer Patients ◽  
Metastatic Breast ◽  
Next Generation ◽  
Breast Cancer Patients ◽  
Esr1 Mutations ◽  
Generation Sequencing

scholarly journals Using next‐generation sequencing to redefine BRCAness in triple‐negative breast cancer

2020 ◽  
Vol 111 (4) ◽  
pp. 1375-1384 ◽  
Author(s):  
Po‐Han Lin ◽  
Ming Chen ◽  
Li‐Wei Tsai ◽  
Chiao Lo ◽  
Tzu‐Chun Yen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Next Generation Sequencing ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Next Generation ◽  
Generation Sequencing

scholarly journals Different Methods in HPV Genotyping of Anogenital and Oropharyngeal Lesions: Comparison between VisionArray® Technology, Next Generation Sequencing, and Hybrid Capture Assay

2021 ◽  
Vol 2 (1) ◽  
pp. 29-41
Author(s):  
Giorgia Acquaviva ◽  
Michela Visani ◽  
Viviana Sanza ◽  
Antonio De Leo ◽  
Thais Maloberti ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Turnaround Time ◽  
Hpv Infection ◽  
Human Papillomaviruses ◽  
Next Generation ◽  
Hybrid Capture ◽  
Capture Assay ◽  
Anogenital Area ◽  
Next Generation Sequencing Ngs ◽  
Generation Sequencing

(1) Background: Human papillomaviruses (HPVs) are known to be related to the development of about 5% of all human cancers. The clinical relevance of HPV infection has been deeply investigated in carcinomas of the oropharyngeal area, uterine cervix, and anogenital area. To date, several different methods have been used for detecting HPV infection. The aim of the present study was to compare three different methods for the diagnosis of the presence of the HPV genome. (2) Methods: A total of 50 samples were analyzed. Twenty-five of them were tested using both next generation sequencing (NGS) and VisionArray® technology, the other 25 were tested using Hybrid Capture (HC) II assay and VisionArray® technology. (3) Results: A substantial agreement was obtained using NGS and VisionArray® (κ = 0.802), as well as between HC II and VisionArray® (κ = 0.606). In both analyses, the concordance increased if only high risk HPVs I(HR-HPVs) were considered as “positive”. (4) Conclusions: Our data highlighted the importance of technical choice in HPV characterization, which should be guided by the clinical aims, costs, starting material, and turnaround time for results.

scholarly journals Next-Generation Sequencing–Based Assessment of JAK2, PD-L1, and PD-L2 Copy Number Alterations at 9p24.1 in Breast Cancer

2019 ◽  
Vol 21 (2) ◽  
pp. 307-317 ◽  
Author(s):  
Sounak Gupta ◽  
Chad M. Vanderbilt ◽  
Paolo Cotzia ◽  
Javier A. Arias-Stella ◽  
Jason C. Chang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Next Generation Sequencing ◽  
Copy Number ◽  
Copy Number Alterations ◽  
Next Generation ◽  
Generation Sequencing

scholarly journals The Important Role of Breast Microbiota in Breast Cancer

2020 ◽  
Author(s):  
Kar-Yan Su ◽  
Wai-Leng Lee ◽  
Vinod Balasubramaniam
Keyword(s):  
Breast Cancer ◽  
Next Generation Sequencing ◽  
Racial Differences ◽  
Breast Tissue ◽  
Bacterial Species ◽  
Cancer Therapies ◽  
Next Generation ◽  
Sequencing Technologies ◽  
Health And Disease ◽  
Generation Sequencing

One in eight women will be diagnosed with breast cancer (BC) in their lifetime, resulting in over 2 million cases annually. BC is the most common cancer among women. Unfortunately, the etiology of majority of cases remains unknown. Recently, evidence has shown that the human microbiota plays an important role in health and disease. Intriguingly, studies have revealed the presence of microorganisms in human breast tissue, which was previously presumed to be sterile. Next-generation sequencing technologies have paved way for the investigation of breast microbiota, uncovering bacterial signatures that are associated with BC. Some of the bacterial species were found to possess pro-carcinogenic and/or anti-carcinogenic properties, suggesting that the breast microbiota has potentially crucial roles in maintenance of breast health. In this review, we summarize the recent findings on breast tissue microbiota and its interplay with BC. Bacterial signatures identified via next-generation sequencing as well as their impact on breast carcinogenesis and cancer therapies are reviewed. Correlation of breast tissue microbiota and other factors, such as geographical and racial differences, in BC is discussed. Additionally, we discuss the future directions of research on breast microbiota as well as its potential role in prevention, diagnosis and treatment of BC.

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