A System for Augmented Reality Guided Laparoscopic Tumour Resection with Quantitative Ex-vivo User Evaluation

2017 ◽  
pp. 114-126 ◽  
Author(s):  
Toby Collins ◽  
Pauline Chauvet ◽  
Clément Debize ◽  
Daniel Pizarro ◽  
Adrien Bartoli ◽  
...  
Keyword(s):  
Augmented Reality ◽  
Ex Vivo ◽  
Tumour Resection ◽  
User Evaluation

scholarly journals Laparoscopic augmented reality registration for oncological resection site repair

2021 ◽  
Author(s):  
Fabian Joeres ◽  
Tonia Mielke ◽  
Christian Hansen
Keyword(s):  
Augmented Reality ◽  
Time Pressure ◽  
Tumour Resection ◽  
Anatomical Landmarks ◽  
Proof Of Concept ◽  
Registration Accuracy ◽  
Target Registration Error ◽  
Concept Evaluation ◽  
Navigation Support ◽  
Challenges And Opportunities

Abstract Purpose Resection site repair during laparoscopic oncological surgery (e.g. laparoscopic partial nephrectomy) poses some unique challenges and opportunities for augmented reality (AR) navigation support. This work introduces an AR registration workflow that addresses the time pressure that is present during resection site repair. Methods We propose a two-step registration process: the AR content is registered as accurately as possible prior to the tumour resection (the primary registration). This accurate registration is used to apply artificial fiducials to the physical organ and the virtual model. After the resection, these fiducials can be used for rapid re-registration (the secondary registration). We tested this pipeline in a simulated-use study with $$N=18$$ N = 18 participants. We compared the registration accuracy and speed for our method and for landmark-based registration as a reference. Results Acquisition of and, thereby, registration with the artificial fiducials were significantly faster than the initial use of anatomical landmarks. Our method also had a trend to be more accurate in cases in which the primary registration was successful. The accuracy loss between the elaborate primary registration and the rapid secondary registration could be quantified with a mean target registration error increase of 2.35 mm. Conclusion This work introduces a registration pipeline for AR navigation support during laparoscopic resection site repair and provides a successful proof-of-concept evaluation thereof. Our results indicate that the concept is better suited than landmark-based registration during this phase, but further work is required to demonstrate clinical suitability and applicability.

scholarly journals Familial Adenomatous Polyposis and Desmoid Tumor Treated with Multivisceral Transplantation and Kidney Autotransplantation: Case Report and Literature Review

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Libor Janousek ◽  
Robert Novotny ◽  
Michal Kudla ◽  
Martin Oliverius ◽  
Petr Wohl ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Deceased Donor ◽  
Multiple Organ ◽  
Nephron Sparing Surgery ◽  
Tumour Resection ◽  
Adenomatous Polyposis ◽  
Multivisceral Transplantation ◽  
Nephron Sparing ◽  
One Year ◽  
Kidney Autotransplantation

Introduction. Desmoid tumours (DT) are commonly associated with Gardener’s syndrome. Their surgical resection may be complicated by their close proximity to major vessels, multiple organ involvement, and frequent local recurrence. Multivisceral transplantation (MVTx) is an alternative treatment for patients with intestinal and liver failure. In patients with DT closely associated with renal structures but without end-stage kidney disease, concomitant excision of the patient’s own kidney, ex vivo tumour resection with nephron-sparing surgery, or autotransplantation has been proposed. Case Presentation. A 36-year-old Caucasian female weighing 60 kg with Gardener’s syndrome with a history of abdominal surgery was presented to our department with progressive abdominal distention associated with paroxysmal pain. With the use of CT, the patient was diagnosed with a mass arising from the mesenterial region. The patient had normal kidney function and nonalcoholic steatohepatitis. The patient was indicated for MVTx. Management and Outcome. After 16 months on the waiting list, the patient received a multivisceral graft from a deceased donor. Following the restoration of graft vascular flow, the patient’s right kidney was removed and the DT dissected ex vivo before autotransplantation into the right pelvic fossa. The patient received immunosuppressive, antithrombotic, and antibiotic treatment. There was no acute rejection, though the patient experienced pulmonary infection, dysphagia, and oesophageal reflux with fungal infection. The patient had required temporary dialysis for acute renal failure for 75 days. One year after the surgery, nausea and violent vomiting caused delayed gastric emptying caused by spastic pylorus. Clinical improvement was achieved using gastric peroral endoscopic myotomy (G-POEM). Conclusion. MVTx with kidney autotransplantation is a feasible treatment option in patients with familiar adenomatous polyposis complicated by an abdominal DT. Precise tumour dissection with nephron-sparing surgery was carried ex vivo. G-POEM was used to relieve MVTx-related gastroparesis. The patient had no disease reoccurrence after one-year follow-up.

scholarly journals User evaluation of mobile augmented reality scenarios

2012 ◽  
Vol 4 (1) ◽  
pp. 29-47 ◽  
Author(s):  
Thomas Olsson ◽  
Tuula Kärkkäinen ◽  
Else Lagerstam ◽  
Leena Ventä-Olkkonen
Keyword(s):  
Augmented Reality ◽  
User Evaluation ◽  
Mobile Augmented Reality

scholarly journals SCIDOT-18. NANOTHERAPEUTICS FOR NEUROSURGICALLY-APPLIED DRUG DELIVERY

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi275-vi275
Author(s):  
Catherine Vasey ◽  
Vincenzo Taresco ◽  
Stuart Smith ◽  
Cameron Alexander ◽  
Ruman Rahman
Keyword(s):  
Drug Delivery ◽  
Ex Vivo ◽  
Drug Formulation ◽  
Local Drug Delivery ◽  
Resection Margins ◽  
Therapeutic Drug ◽  
Tumour Resection ◽  
Combination Drug ◽  
Drug Encapsulation ◽  
Drug Concentrations

Abstract Design and implementation of innovative local drug delivery systems (DDS) may overcome current limitations in GBM treatment, such as the lack of therapeutic drug concentrations reaching residual GBM cells following surgery. Here we describe a novel DDS which utilises a bespoke mechanically engineered spray device, designed for safe surgical use, to deliver a mucoadhesive hydrogel containing chemotherapeutic nanoparticles (NPs) into the tumour resection margins. The overall aim is to spray a NP and polymer solution onto the resection cavity and potentially increase penetration of anti-cancer drugs within the 2 cm reoccurrence zone beyond the infiltrative margin. The mucoadhesive gel of choice, pectin, is currently used in other in vivo applications; however we have repurposed this for the brain. Pectin is biocompatible with GBM and human astrocyte cells in vitro and showed neither toxicity nor inflammation for up to 2 weeks upon orthotopic brain injection. Pectin is biodegradable in artificial CSF and is capable of being sprayed from the engineered device. A panel of polymeric, oil-based and polymer-coated NPs have been developed and optimised to maximise drug encapsulation of etoposide and olaparib as proof-of-concept for combination drug delivery. Etoposide/olaparib was chosen due to cytotoxicity from 5 GBM cell lines, including primary lines isolated from the invasive tumour margin (Mean IC50 of 1.1 µM and 8.3 µM respectively). The optimal NP/drug formulation (based on drug encapsulation, spray capability and bio-adhesiveness) will ultimately be assessed for tolerability and efficacy using orthotopic allograft and xenograft high-grade glioma models, including measurement of penetration of drug/nanoparticle in ex vivo murine and porcine brain using novel hybrid time-of-flight/Orbitrap TM secondary ion mass spectrometer (orbiSIMS) technology.

scholarly journals Mobile AR: User Evaluation in a Cultural Heritage Context

2019 ◽  
Vol 9 (24) ◽  
pp. 5454
Author(s):  
Anabela Marto ◽  
Alexandrino Gonçalves
Keyword(s):  
Augmented Reality ◽  
Cultural Heritage ◽  
Archaeological Site ◽  
User Evaluation ◽  
Virtual Model ◽  
Mobile Augmented Reality ◽  
Heritage Sites ◽  
Augmented Reality Application ◽  
Mobile Ar

The growing number of mobile augmented reality applications has been favoring its awareness and usage among diversified areas. Focusing on cultural heritage applications, this study presents an evaluation of a mobile augmented reality application tested at Conimbriga, an archaeological site. The prototype developed for this purpose, named DinofelisAR, allowed users to view, over 360 degrees, a majestic reconstruction of a Forum from the Roman Era superimposed over its current ruins. Thus, users were able to keep perceiving the present-day surroundings of a Roman city in ruins while, at the same time, had the possibility to explore the matching virtual model. The results presented, arising from 90 participants involved in this evaluation, praise the sense of opportunity for new augmented reality solutions targeted at cultural heritage sites.

scholarly journals An effective approach to develop location-based augmented reality information support

2019 ◽  
Vol 9 (4) ◽  
pp. 3060
Author(s):  
Komang Candra Brata ◽  
Deron Liang
Keyword(s):  
Augmented Reality ◽  
Deep Understanding ◽  
Information Support ◽  
User Evaluation ◽  
Functional Requirements ◽  
Pedestrian Navigation ◽  
The Right ◽  
Study Participants ◽  
Software Requirement Specification

Using location-based augmented reality (AR) for pedestrian navigation can greatly improve user action to reduce the travel time. Pedestrian navigation differs in many ways from the conventional navigation system used in a car or other vehicles. A major issue with using location-based AR for navigation to a specific landmark is their quality of usability, especially if the active screen is overcrowded with the augmented POI markers which were overlap each other at the same time. This paper describes the user journey map approach that led to new insights about how users were using location-based AR for navigation. These insights led to a deep understanding of challenges that user must face when using location-based AR application for pedestrian navigation purpose, and more generally, they helped the development team to appreciate the variety of user experience in software requirement specification phase. To prove our concept, a prototype of intuitive location-based AR was built to be compared with existing standard-location based AR. The user evaluation results reveal that the overall functional requirements which are gathered from user journey have same level of success rate criteria when compared with standard location-based AR. Nevertheless, the field study participants highlighted the extended features in our prototype could significantly enhance the user action on locating the right object in particular place when compared with standard location-based AR application (proved with the required time).

Detectability and structural stability of a liquid fiducial marker in fresh ex vivo pancreas tumour resection specimens on CT and 3T MRI

2019 ◽  
Vol 195 (8) ◽  
pp. 756-763 ◽  
Author(s):  
Sergej Schneider ◽  
Daniela E. Aust ◽  
Stefan Brückner ◽  
Thilo Welsch ◽  
Jochen Hampe ◽  
...  
Keyword(s):  
Structural Stability ◽  
Ex Vivo ◽  
Fiducial Marker ◽  
Tumour Resection ◽  
3T Mri ◽  
Pancreas Tumour

Fluorescence-guided surgery using indocyanine green in dogs with superficial solid tumours

2020 ◽  
Vol 187 (7) ◽  
pp. 273-273
Author(s):  
Sophie Favril ◽  
Eline Abma ◽  
Emmelie Stock ◽  
Nausikaa Devriendt ◽  
Bart Van Goethem ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Near Infrared ◽  
Ex Vivo ◽  
False Positive Rate ◽  
Tumour Tissue ◽  
Surrounding Tissue ◽  
Tumour Resection ◽  
Nirf Imaging ◽  
Tumour Delineation

BackgroundNear-infrared fluorescence (NIRF) imaging is a relatively novel technique that can aid surgeons during intraoperative tumour identification.MethodsNine canine oncology patients (five mammary gland tumours, three mast cell tumours and one melanoma) received intravenous indocyanine green (ICG). After 24 hours, tumours were resected and fluorescence intensities of tumours and surroundings were evaluated. Additional wound bed tissue was resected if residual fluorescence was present after tumour resection. Ex vivo, fluorescence-guided dissection was performed to separate tumour from surrounding tissue.ResultsIntraoperative NIRF-guided tumour delineation was feasible in four out of nine dogs. Wound bed imaging after tumour removal identified nine additional fluorescent lesions, of which four contained tumour tissue. One of these four true positive in vivo lesions was missed by standard-of-care inspection. Ex vivo fluorescence-guided tumour dissection showed a sensitivity of 72 per cent and a specificity of 80 per cent in discriminating between tumour and surrounding tissue.ConclusionThe value of ICG for intraoperative tumour delineation seems more limited than originally thought. Although NIRF imaging using ICG did identify remaining tumour tissue in the wound bed, a high false positive rate was also observed.

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